[1]田雨苗 吕冬青 任毅 杨静.PCSK9抑制剂在糖尿病患者调脂治疗中的应用[J].国际内分泌代谢杂志,2019,39(04):241-244.[doi:10.3760/cma.j.issn.1673-4157.2019.04.006]
 Tian Yumiao,Lyu Dongqing,Ren Yi,et al.Application of PCSK9 inhibitors in lipid-regulating therapy in patients with diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2019,39(04):241-244.[doi:10.3760/cma.j.issn.1673-4157.2019.04.006]
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PCSK9抑制剂在糖尿病患者调脂治疗中的应用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
241-244
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Application of PCSK9 inhibitors in lipid-regulating therapy in patients with diabetes mellitus
作者:
田雨苗1 吕冬青1 任毅12 杨静2
1山西医科大学,太原 030001; 2山西医科大学第一医院内分泌科,太原 030001
Author(s):
Tian Yumiao1 Lyu Dongqing1 Ren Yi12 Yang Jing2
1Shanxi Medical University, Taiyuan 030001, China; 2Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan 030001, China
关键词:
PCSK9抑制剂 糖尿病 LDL-C 心血管事件
Keywords:
PCSK9 inhibitor Diabetes mellitus LDL-C Cardiovascular events
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.006
摘要:
前蛋白转化酶枯草溶菌素9(PCSK9)抑制剂能够使低密度脂蛋白受体(LDL-R)的降解减少,增加LDL-R在肝细胞表面与低密度脂蛋白-胆固醇(LDL-C)结合的机会,使得LDL-C进入肝脏被清除,降低LDL-C水平及心血管事件的发生率。循环中的PCSK9抑制剂不影响血糖的调控,能够使糖尿病患者糖化血红蛋白及空腹血糖保持稳定,不增加血糖正常者的糖尿病患病率,是目前降脂药物的新靶点。
Abstract:
Preprotein convertase subtilisin/kexin type 9(PCSK9)inhibitor can reduce the degradation of low density lipoprotein receptor(LDL-R), increase the opportunity for LDL-R to bind to low density lipoprotein-cholesterol(LDL-C)on the surface of hepatocytes, make LDL-C enter the liver and be cleared, thereby reducing the level of LDL-C and the incidence of cardiovascular events. PCSK9 inhibitors in circulation do not affect the regulation of blood glucose, which can keep glycosylated hemoglobin and fasting blood glucose stable in diabetic patients, and do not increase the prevalence of diabetes in people with normal blood glucose. So PCSK9 inhibitors are the new targets of lipid-lowering drugs at present.

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备注/Memo

备注/Memo:
通信作者:杨静, Email:yangjlm@126.com
Corresponding author: Yang Jing, Email:yangjlm@126.com
基金项目:国家自然科学基金(81270882); 山西省自然科学基金(2014011043-3)
Fund program:National Natural Science Foundation of China(81270882); Natural Science Foundation of Shanxi Provicine of China(2014011043-3)
更新日期/Last Update: 2019-11-29