[1]唐勤,邵莉.蛋白乙酰化与胰岛素分泌[J].国际内分泌代谢杂志,2014,(05):313-315,333.[doi:10.3760/cma.j.issn.1673-4157.2014.05.007]
 Tang Qin,Shao Li..Protein acetylation and insulin secretion[J].International Journal of Endocrinology and Metabolism,2014,(05):313-315,333.[doi:10.3760/cma.j.issn.1673-4157.2014.05.007]
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蛋白乙酰化与胰岛素分泌()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
313-315,333
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Protein acetylation and insulin secretion
作者:
唐勤邵莉
200120 上海,同济大学附属东方医院老年医学科
Author(s):
Tang QinShao Li.
Department of Gerontology,East Hospital Affiliated to Tongji University,Shanghai 200120,China Corresponding author:Shao Li,Email:dongfangshaoli@126.com
关键词:
蛋白乙酰化 糖尿病 胰岛素分泌
Keywords:
Protein acetylation Diabetes mellitus Insulin secretion
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.007
摘要:
蛋白乙酰化直接或间接参与胰岛素分泌的调节。多项研究证实组蛋白乙酰化通过对多种组蛋白乙酰基转移酶和组蛋白去乙酰化酶的动态调节,参与调节葡萄糖刺激的胰岛β细胞分泌功能,从而直接或间接地在糖尿病的发生、发展中起重要作用。胰岛β细胞骨架蛋白乙酰化可调节细胞骨架系统运送胰岛素颗粒的活力,进而参与调节葡萄糖刺激的胰岛素分泌。对蛋白乙酰化的深入研究将为糖尿病的防治提供新的思路。
Abstract:
Protein acetylation is involved in the secretion of insulin directly or indirectly. A number of studies confirm that protein acetylation is involved in the regulation of glucose-stimulated insulin secretion from islet β cells through dynamic regulation of a variety of histone acetyltransferase(HAT)and histone deacetylase(HDAC), which directly or indirectly plays an important role in the development of diabetes. Acetylation of cytoskeletal protein in islet β cells can regulate the activity of cytoskeletal system delivering insulin granules, then involve in the regulation of glucose-stimulated insulin secretion. In-depth study of histone acetylation will provide new ideas for prevention and treatment of diabetes.

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备注/Memo

备注/Memo:
基金项目:上海市浦东新区卫生系统学科带头人培养计划(PWRd2011-01),上海市浦东新区科委课题(PKJ2012-Y07) 通信作者:邵莉,Email:dongfangshaoli@126.com
更新日期/Last Update: 2014-09-20