[1]包薇萍,陈国芳,刘超.DPP-4抑制剂的肾保护作用[J].国际内分泌代谢杂志,2014,(05):337-339,347.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
 Bao Weiping,Chen Guofang,Liu Chao..Renal protective effects of dipeptidyl peptidase-4 inhibitors[J].International Journal of Endocrinology and Metabolism,2014,(05):337-339,347.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
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DPP-4抑制剂的肾保护作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
337-339,347
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Renal protective effects of dipeptidyl peptidase-4 inhibitors
作者:
包薇萍陈国芳刘超
210028 南京,中国中医科学院江苏分院,南京中医药大学附属中西医结合医院,内分泌代谢病院区
Author(s):
Bao Weiping Chen Guofang Liu Chao.
Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210028, China Corresponding au
关键词:
DPP-4抑制剂 肾功能不全 糖尿病
Keywords:
DPP-4 inhibitors Renal dysfunction Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.014
摘要:
二肽基肽酶-4(DPP-4)抑制剂作为一类新型糖尿病治疗药物,具有降糖之外的肾保护作用。研究表明,DPP-4抑制剂单用或与其他药物联用都有肾保护作用,具有治疗效果显著、服用安全,耐受性好,不良反应少等特点。其肾保护作用机制可能与抗炎、血管内皮保护作用、减少缺血-再灌注损伤、降低血压、改善血脂异常有关。
Abstract:
Dipeptidyl peptidase-4(DPP-4)inhibitors are a new class of anti-diabetic drugs.Many studies have shown that DPP-4 inhibitors have a protective effect on kidney. Monotherapy or in combination with other drugs is efficacious, well tolerated, and safe in clinical application. The underlying mechanisms for their renal protective effect involve the suppression of inflammation, protection of vascular endothelial cell, reduction of ischemia/reperfusion injury, reducing blood pressure, and the improvment of plasma lipid profile.

参考文献/References:

[1] Arjona Ferreira JC, Marre M, Barzilai N, et al. Efficacy and safety of sitagliptin versus glipizide in patients with type 2 diabetes and moderate-to-severe chronic renal insufficiency[J].Diabetes Care, 2013,36(5):1067-1073.
[2] Mcgill JB, Sloan L, Newman J, et al. Long-Term efficacy and safety of linagliptin in patients with type2 diabetes and severe renal impairment[J].Diabetes Care, 2013,36(2):237-244.
[3] Haidinger M, Werzowa J, Voigt HC, et al. A randomized, placebo-controlled, double-blind, prospective trial to evaluate the effect of vildagliptin in new-onset diabetes mellitus after kidney transplantation[J].Trials, 2010, 11: 91.
[4] Gallwitz B. Safety and efficacy of linagliptin in type 2 diabetes patients with common renal and cardiovascular risk factors[J]. Ther Adv Endocrinol Metab, 2013, 4: 95-105.
[5] Haluzík M, Frolík J, Rychlík I. Renal effects of DPP-4 inhibitors: A focus on microalbuminuria[J]. Int J Endocrinol, 2013, 2013: 895102.
[6] Hattori S. Sitagliptin reduces albuminuria in patients with type 2 diabetes[J]. Endocr J,2011,58(1):69-73.
[7] Harashima SI, Ogura M, Tanaka D, et al. Sitagliptin add-on to low dosage sulphonylureas: efficacy and safety of combination therapy on glycaemic control and insulin secretion capacity in type 2 diabetes[J].Int J Clin Pract, 2012,66(5):465-476.
[8] Groop PH, Cooper ME, Perkovic V, et al. Linagliptin lowers albuminuria on top of recommended standard treatment in patients with type 2 diabetes and renal dysfunction[J].Diabetes Care, 2013,36(11):3460-3468.
[9] Ferreira L, Teixeira-de-Lemos E, Pinto F, et al. Effects of sitagliptin treatment on dysmetabolism, inflammation, and oxidative stress in an animal model of type 2 diabetes(ZDF rat). Mediators Inflamm, 2010, 2010: 592760.
[10] Shah Z, Kampfrath T, Deiuliis JA, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis[J].Circulation, 2011,124(21):2338-2349.
[11] Akarte AS, Srinivasan BP, Gandhi S, et al. Chronic DPP-IV inhibition with PKF-275-055 attenuates inflammation and improves gene expressions responsible for insulin secretion in streptozotocin induced diabetic rats[J].Eur J Pharm Sci, 2012,47(2):456-463.
[12] Satoh-Asahara N, Sasaki Y, Wada H, et al. A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients[J].Metabolism,2013,62(3):347-351.
[13] Rizzo MR, Barbieri M, Marfella R, et al. Reduction of oxidative stress and inflammation by blunting daily acute glucose fluctuations in patients with type 2 diabetes: role of dipeptidyl peptidase-Ⅳ inhibition[J].Diabetes Care, 2012,35(10):2076-2082.
[14] Shah Z, Pineda C, Kampfrath T, et al. Acute DPP-4 inhibition modulates vascular tone through GLP-1 independent pathways[J].Vascul Pharmacol, 2011,55(1-3):2-9.
[15] Xiao-Yun X, Zhao-Hui M, Ke C, et al. Glucagon-like peptide-1 improves proliferation and differentiation of endothelial progenitor cells via upregulating VEGF Generation[J].Med Sci Monit, 2011,17(2):BR35-BR41.
[16] Glorie LL, Verhulst A, Matheeussen V, et al. DPP4 inhibition improves functional outcome after renal ischemia-reperfusion injury[J].Am J Physiol Renal Physiol, 2012,303(5):F681-F688.
[17] Pacheco BP, Crajoinas RO, Couto GK, et al. Dipeptidyl peptidase IV inhibition attenuates blood pressure rising in young spontaneously hypertensive rats[J].J Hypertens, 2011,29(3):520-528.
[18] Rieg T, Gerasimova M, Murray F, et al. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice[J].Am J Physiol Renal Physiol, 2012,303(7):F963-F971.
[19] Derosa G,Ragonesi PD, Fogari E,et al. Sitagliptin added to previously taken antidiabetic agents on insulin resistance and lipid profile: a 2-year study evaluation. Fundam Clin Pharmacol,2014,28(2):221-229.
[20] Monami M, Lamanna C, Desideri CM, et al. DPP-4 inhibitors and lipids: systematic review and meta-analysis[J].Adv Ther, 2012,29(1):14-25.

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备注/Memo

备注/Memo:
通信作者:刘超,Email: liuchao@nfmcn.com
更新日期/Last Update: 2014-09-20