[1]孟庆冬,陶红.巨噬细胞凋亡与糖尿病动脉粥样硬化[J].国际内分泌代谢杂志,2014,(05):340-343.[doi:10.3760/cma.j.issn.1673-4157.2014.05.015]
 Meng Qingdong,Tao Hong..Macrophage apoptosis and diabetic atherosclerosis[J].International Journal of Endocrinology and Metabolism,2014,(05):340-343.[doi:10.3760/cma.j.issn.1673-4157.2014.05.015]
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巨噬细胞凋亡与糖尿病动脉粥样硬化()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
340-343
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Macrophage apoptosis and diabetic atherosclerosis
作者:
孟庆冬陶红
100029 首都医科大学附属北京安贞医院内分泌代谢科
Author(s):
Meng QingdongTao Hong.
Department of Endocrinology and Metabolism,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China Corresponding author:Tao Hong,Email:vivientao@126.com
关键词:
巨噬细胞凋亡 糖尿病 动脉粥样硬化
Keywords:
Macrophage apoptosis Diabetes mellitus Atherosclerosis
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.015
摘要:
在动脉粥样硬化性病变的进展过程中,一个关键的步骤就是易损斑块的形成。而巨噬细胞凋亡可促进斑块的进展,并与易损斑块形成密切相关。动脉粥样硬化性血管疾病是糖尿病主要并发症之一,因此总结与糖尿病相关的脂代谢紊乱、胰岛素抵抗、脂肪因子等巨噬细胞凋亡影响因素,并初步探讨其介导斑块内巨噬细胞凋亡的信号转导途径,对于防治糖尿病患者动脉粥样硬化具有重要意义。
Abstract:
During the progress of atherosclerotic lesions, the formation of the vulnerable plaque is a critical step.Macrophage apoptosis can promote the progress of plaque, and is closely related to vulnerable plaque formation. Since atherosclerotic vascular disease is a major complication of diabetes mellitus, the factors associated with macrophage apoptosis, such as dyslipidemia, insulin resistance and adipokines etc,which are related to diabetes mellitus are summarized, and the signaling pathways that mediate macrophage apoptosis in the atherosclerotic lesions are also discussed. Deep understanding of the mechanism is important for the prevention and treatment of atherosclerosis in patients with diabetes mellitus.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81100600) 通信作者:陶红,Email:vivientao@126.com
更新日期/Last Update: 2014-09-20