[1]郑佳,肖新华.葡萄糖稳态的中枢调控作用机制 ——2014年美国糖尿病协会“杰出科学成就奖” 演讲报告解读[J].国际内分泌代谢杂志,2014,(05):305-307.[doi:10.3760/cma.j.issn.1673-4157.2014.05.004]
 Zheng Jia,Xiao Xinhua.The mechanisms of central nervous system in the control of glucose homeostasis--A summary of 2014 ADA "Outstanding Scientific Achievement Award" Lecture[J].International Journal of Endocrinology and Metabolism,2014,(05):305-307.[doi:10.3760/cma.j.issn.1673-4157.2014.05.004]
点击复制

葡萄糖稳态的中枢调控作用机制 ——2014年美国糖尿病协会“杰出科学成就奖” 演讲报告解读()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
305-307
栏目:
会议连线
出版日期:
2014-10-31

文章信息/Info

Title:
The mechanisms of central nervous system in the control of glucose homeostasis--A summary of 2014 ADA "Outstanding Scientific Achievement Award" Lecture
作者:
郑佳肖新华
100730 北京,中国医学科学院; 北京协和医学院; 北京协和医院内分泌科; 卫生部内分泌重点实验室
Author(s):
Zheng JiaXiao Xinhua
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China Corresponding author:Xiao Xinhua,Email:xia
关键词:
葡萄糖稳态 中枢调控 糖尿病
Keywords:
Glucose homeostasis Central nervous regulation Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.004
摘要:
2014年第74届美国糖尿病协会年会上,美国德克萨斯大学西南医学中心Joel K. Elmquist教授获得了杰出科学成就奖,并发表了关于“Claude Bernard是正确的——葡萄糖稳态的大脑调控(Claude Bernard Was Right——Brain Control of Glucose Homeostasis)”的获奖演讲。现对其演讲报告作一简短的解读,探讨中枢神经系统对葡萄糖稳态的调控作用机制。
Abstract:
At the American Diabetes Association's 74th Scientific Sessions in 2014,professor Joel K. Elmquist from the university of Texas southwestern medical center was awarded the American Diabetes Association's Outstanding Scientific Achievement Award. Dr. Elmquist presented the Outstanding Scientific Achievement Award Lecture, "Claude Bernard Was Right: Brain Control of Glucose Homeostasis" at the Scientific Sessions. Here briefly interpretaed his award lecture which focused on the mechanisms of central nervous system on the regulation in glucose homeostasis.

参考文献/References:

[1] Schwartz MW, Porte D Jr. Diabetes, obesity, and the brain[J].Science,2005,307(5708):375-379.
[2] Williams KW, Scott MM, Elmquist JK. Modulation of the central melanocortin system by leptin, insulin, and serotonin: co-ordinated actions in a dispersed neuronal network[J].Eur J Pharmacol, 2011,660(1):2-12.
[3] Vogt MC, Bruning JC. CNS insulin signaling in the control of energy homeostasis and glucose metabolism-from embryo to old age[J].Trends Endocrinol Metab,2013,24(2):76-84.
[4] Yeo GS, Heisler LK.Unraveling the brain regulation of appetite: lessons from genetics[J].Nat Neurosci,2012,15(10):1343-1349.
[5] Padilla SL, Carmody JS, Zeltser LM.Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits[J].Nat Med,2010,16(4):403-405.
[6] Konner AC,Janoschek R,Plum L, et al.Insulin action in AgRP-expressing neurons is required for suppression of hepatic glucose production[J].Cell Metab,2007,5(6):438-449.
[7] Woods SC.The control of food intake: behavioral versus molecular perspectives[J].Cell Metab,2009,9(6):489-498.
[8] Berglund ED, Vianna CR, Donato J, et al. Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice[J].J Clin Invest,2012,122(3):1000-1009.
[9] Sohn JW, Harris LE, Berglund ED,et al.Melanocortin 4 receptors reciprocally regulate sympathetic and parasympathetic preganglionic neurons[J].Cell, 2013,152(3):612-619.
[10] Xu Y, Berglund ED, Sohn JW, et al. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate insulin sensitivity in liver[J].Nat Neurosci,2010,13(12):1457-1459.
[11] Cui H, Sohn JW, Gautron L,et al. Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area[J].J Comp Neurol,2012,520(18):4168-4183.
[12] Rossi J, Balthasar N, Olson D, et al.Melanocortin-4 receptors expressed by cholinergic neurons regulate energy balance and glucose homeostasis[J].Cell Metab,2011,13(2):195-204.
[13] Myers MG,Cowley MA,Munzberg H. Mechanisms of leptin action and leptin resistance[J].Annu Rev Physiol,2008,70:537-556.
[14] Vaughan CH, Shrestha YB,Bartness TJ.Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis[J].Brain Res,2011,1411:17-27.
[15] Berglund ED, Liu T, Kong X,et al.Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia[J].Nat Neurosci,2014,17(7):911-913.

相似文献/References:

[1]姚红,郗光霞,郭敏,等.胰高血糖素样肽-1及其受体在中枢神经系统的分布和功能[J].国际内分泌代谢杂志,2014,(01):36.[doi:10.3760/cma.j.issn.1673-4157.2014.01.010]
 Yao Hong*,Xi Guangxia,Guo Min,et al.The distributions and functions of glucagon like peptide-1 and its receptors in the central nervous system[J].International Journal of Endocrinology and Metabolism,2014,(05):36.[doi:10.3760/cma.j.issn.1673-4157.2014.01.010]

备注/Memo

备注/Memo:
通信作者:肖新华,Email:xiaoxinhua@medmail.com.cn
更新日期/Last Update: 2014-09-20