[1]黄珊珊,鲁一兵.长链非编码RNA与糖尿病[J].国际内分泌代谢杂志,2015,(04):271-274.[doi:10.3760/cma.j.issn.1673-4157.2015.04.016]
　Huang Shanshan*,Lu Yibing..Long non-coding RNA and diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(04):271-274.[doi:10.3760/cma.j.issn.1673-4157.2015.04.016]
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长链非编码RNA与糖尿病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年04
页码:
271-274
栏目:
综述
出版日期:
2015-07-20

文章信息/Info

Title:
Long non-coding RNA and diabetes mellitus
作者:
黄珊珊; 鲁一兵
210011　南京医科大学第二临床医学院（黄珊珊）；南京医科大学第二附属医院内分泌科（鲁一兵）
Author(s):
Huang Shanshan*; Lu Yibing.
*Department of Endocrinology，The Second Affiliated Hospital of Nanjing Medical University，Nanjing 210000，China Corresponding author：Lu Yibing，Email：luyibing2004@126.com
关键词:
长链非编码RNA;  糖尿病
Keywords:
Long non-coding RNA; Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2015.04.016
摘要:
长链非编码RNA在生命活动中具有重要的调节功能，其表达紊乱与多种人类疾病密切相关。LncRNA通过信号模式、诱饵模式、指引模式及支架模式等发挥调控基因表达的作用。近年来，研究证实一些lncRNA，如ANRIL、PVT1、HI-LNC25、H19和Airn、MIAT 、MEG3、Hymai等是参与糖尿病发生、发展的重要调控分子，这些lncRNA将成为新的诊断标志物及治疗靶点。
Abstract:
Long non-coding RNAs（lncRNAs） play important roles in biological processes and the dysregulation of lncRNAs is strongly related to a variety of human diseases. LncRNAs execute molecular functions through signals，decoys，guides，and scaffolds model to regulate gene expression. In recent years，some studies confirm that lncRNAs，such as ANRIL，PVT1，HI-LNC25，H19，Airn，MIAT，MEG3，Hymai are important regulatory molecules participate in the occurrence and development of diabetes. Furthermore，those lncRNAs may be new diagnostic markers and therapeutic targets.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金资助项目（81270896） 　　通信作者：鲁一兵，Email：luyibing2004@126.com
更新日期/Last Update: 2015-07-20