[1]赵一璟 王昆 刘超.噻唑烷二酮类药物临床实用价值和安全性的再认识[J].国际内分泌代谢杂志,2019,39(04):236-240.[doi:10.3760/cma.j.issn.1673-4157.2019.04.005]
 Zhao Yijing,Wang Kun,Liu Chao.Reconsideration of the efficacy and safety of thiazolidinediones[J].International Journal of Endocrinology and Metabolism,2019,39(04):236-240.[doi:10.3760/cma.j.issn.1673-4157.2019.04.005]
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噻唑烷二酮类药物临床实用价值和安全性的再认识()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
236-240
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Reconsideration of the efficacy and safety of thiazolidinediones
作者:
赵一璟1 王昆1 刘超2
1南京医科大学附属江宁医院内分泌科 210000; 2南京中医药大学附属中西医结合医院内分泌科 210028
Author(s):
Zhao Yijing1 Wang Kun1 Liu Chao2
1Department of Endocrinology, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210000, China; 2Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine,Nanjing 210008, China
关键词:
噻唑烷二酮类药物 2型糖尿病 心血管事件 骨质疏松症
Keywords:
Thiazolidinediones Type 2 diabetes mellitus Cardiovascular effects Osteoporosis
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.005
摘要:
噻唑烷二酮类药物降糖疗效确切,是预防糖尿病疗效最明显的降糖药。近年来,这类药物不断被发掘出新的作用,其在降低心血管风险、肿瘤防治、改善非酒精性脂肪性肝病、多囊卵巢综合征等方面均显示出较好的疗效,并受到越来越多的关注和指南推荐。尽管噻唑烷二酮类药物疗效确切,但该类药物的安全性问题,如充血性心力衰竭、骨质疏松症、膀胱癌等,依然引发着人们的担忧。
Abstract:
Thiazolidinediones(TZDs)is effective in treatment of type 2 diabetes mellitus(T2DM)and is the most effective hypoglycemic drug in preventing diabetes. In recent years, the new applications of this kind of medicine have been constantly developed,including certain effects in reducing cardiovascular risk, preventing and treating cancer, improving nonalcoholic fatty liver disease, polycystic ovary syndrome and so on. Although TZDs have an established efficacy in the of treatment of T2DM, their usage during the past years was questioned following the emergence of some alarming data regarding their safety, such as congestive heart-failure, osteoporosis, bladder cancer and so on.

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备注/Memo

备注/Memo:
通信作者:刘超,Email:liuchao@nfmcn.com
Corresponding author: Liu Chao, Email:liuchao@nfmcn.com
更新日期/Last Update: 2019-11-29