铬与2型糖尿病-《国际内分泌代谢杂志》

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Title:: Chromium and type 2 diabetes

作者:: 陈双双; 王楚媛; 孔令芳; 110001 沈阳,中国医科大学附属第一医院内分泌与代谢病科

Author(s):: Chen Shuangshuang; Wang Chuyuan; Kong Lingfang; Department of Endocrinology and Metabolism, The First Affiliated Hospital of China Medical University, Shenyang 110001, China

关键词:: 铬; 葡萄糖耐量因子; 胰岛素敏感性; 2型糖尿病

Keywords:: Chromium; Glucose tolerance factor; Insulin sensitivity; Type 2 diabetes mellitus

DOI:: 10.3760/cma.j.issn.1673-4157.2016.04.13

摘要:: Cr³⁺是人类及动物必须的微量元素,是葡萄糖耐量因子的中心活性成分,与2型糖尿病有密切的联系。研究表明,铬缺乏可能是2型糖尿病发生、发展的一种危险因素。2型糖尿病患者的血铬浓度明显低于健康人,对糖尿病患者进行铬剂补充能够改善胰岛素敏感性,增强胰岛β细胞的功能活性,进而改善糖、脂代谢状况。Cr³⁺化合物作为营养补充剂已广泛用于2型糖尿病的临床治疗。

Abstract:: Trivalent chromium, an essential trace element for human and animals, is an active component of glucose tolerance factor, which is closely related to type 2 diabetes. Studies indicated, trivalent chromium deficiency may be considered as a possible risk factor in the occurrence and development of type 2 diabetes. Serum chromium concentration in type 2 diabetic patients was lower than that in healthy population, and chromium supplements could improve insulin sensitivity, enhance the function of islet β cells, ultimately affect glucose and lipid metabolism in patients with diabetes. Trivalent chromium compound has been widely used in the clinical treatment of type 2 diabetes as a dietary supplement.

参考文献/References:

[1] Schwarz K, Mertz W. A glucose tolerance factor and its differentiation J from factor 3[J]. Arch Biochem Biophys,1957,72(2):515-518.
[2] Padmavathi IJ, Rao KR, Raghunath M. Impact of maternal chromium restriction on glucose tolerance, plasma insulin and oxidative stress in WNIN rat offspring[J].J Mol Endocrinol,2011,47(3):261-271. DOI: 10.1530/JME-11-0010.
[3] Rafiei R, Habyby Z, Fouladi L,et al.Chromium level in prediction of diabetes in pre-diabetic patient[J].Adv Biomed Res,2014,3:235. DOI: 10.4103/2277-9175.145737.
[4] Karagun BS, Temiz F, Ozer G,et al. Chromium levels in healthy and newly diagnosed type 1 diabetic children[J]. Pediatr Int,2012,54(6):780-785. DOI: 10.1111/j.1442-200X.2012.03696.x.
[5] Forte G, Bocca B, Peruzzu A,et al. Blood metals concentration in type 1 and type 2 diabetics[J].Biol Trace Elem Res,2013,156(1-3):79-90. DOI: 10.1007/s12011-013-9858-6.
[6] Suksomboon N, Poolsup N, Yuwanakorn A. Systematic review and meta-analysis of the efficacy and safety of chromium supplementation in diabetes[J].J Clin Pharm Ther,2014,39(3):292-306. DOI: 10.1111/jcpt.12147.
[7] Staniek H, Rhodes NR, Di Bona KR,et al. Comparison of tissue metal concentrations in Zucker lean, Zucker obese, and Zucker diabetic fatty rats and the effects of chromium supplementation on tissue metal concentrations[J].Biol Trace Elem Res,2013,151(3):373-383. DOI: 10.1007/s12011-012-9565-8.
[8] Zhang Q, Xiao XH, Li M,et al. Chromium-containing traditional Chinese medicine, Tianmai Xiaoke Tablet improves blood glucose through activating insulin-signaling pathway and inhibiting PTP1B and PCK2 in diabetic rats[J].J Integr Med,2014,12(3):162-170. DOI: 10.1016/S2095-4964(14)60020-0.
[9] Mozaffari MS, Baban B, Abdelsayed R,et al. Renal and glycemic effects of high-dose chromium picolinate in db/db mice: assessment of DNA damage[J].J Nutr Biochem,2012,23(8):977-985. DOI: 10.1016/j.jnutbio.2011.05.004.
[10] Dogukan A, Tuzcu M, Juturu V,et al. Effects of chromium histidinate on renal function, oxidative stress, and heat-shock proteins in fat-fed and streptozotocin-treated rats[J].J Ren Nutr,2010,20(2):112-120. DOI: 10.1053/j.jrn.2009.04.009.
[11] Ulas M, Orhan C, Tuzcu M,et al. Anti-diabetic potential of chromium histidinate in diabetic retinopathy rats[J].BMC Complement Altern Med,2015,15:16. DOI: 10.1186/s12906-015-0537-3.
[12] Racek J, Sindberg CD, Moesgaard S,et al. Effect of chromium-enriched yeast on fasting plasma glucose, glycated haemoglobin and serum lipid levels in patients with type 2 diabetes mellitus treated with insulin[J].Biol Trace Elem Res,2013,155(1):1-4. DOI: 10.1007/s12011-013-9758-9.
[13] Guimarães MM, Martins Silva Carvalho AC, Silva MS. Chromium nicotinate has no effect on insulin sensitivity, glycemic control, and lipid profile in subjects with type 2 diabetes[J].J Am Coll Nutr,2013,32(4):243-250.DOI:10.1080/07315724.2013.816598.111. [1] Guariguata L, Whiting DR, Hambleton I, et al. Global estimates of diabetes prevalence for 2013 and projections for 2035[J]. Diabetes Res Clin Pract,2014,103(2):137-149. DOI: 10.1016/j.diabres.2013.11.002.
[2] Greig M, Tesfaye S, Selvarajah D, et al. Insights into the pathogenesis and treatment of painful diabetic neuropathy[J].Handb Clin Neurol,2014,126:559-578.DOI:10.1016/B978-0-444-53480-4.00037-0.
[3] Xu X, Chen H, Ling BY, et al. Extracellular signal-regulated protein kinase activation in spinal cord contributes to pain hypersensitivity in a mouse model of type 2 diabetes[J].Neurosci Bull,2014,30(1):53-66. DOI: 10.1007/s12264-013-1387-y.
[4] Migita K, Moriyama T, Koguchi M,et al. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy[J].Neurosci Lett,2009,452(2):200-203. DOI: 10.1016/j.neulet.2009.01.048.
[5] Xu GY, Li G, Liu N,et al. Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats[J].Mol Pain,2011,7:60.DOI:10.1186/1744-8069-7-60.
[6] Tuncay E, Zeydanli EN, Turan B. Cardioprotective effect of propranolol on diabetes-induced altered intracellular Ca²⁺ signaling in rat[J].J Bioenerg Biomembr,2011,43(6):747-756. DOI: 10.1007/s10863-011-9400-5.
[7] Kim YH, Kim YS, Kang SS, et al. Resveratrol inhibits neuronal apoptosis and elevated Ca²⁺/calmodulin-dependent protein kinase Ⅱ activity in diabetic mouse retina[J].Diabetes,2010,59(7):1825-1835. DOI: 10.2337/db09-1431.
[8] Kim YH, Kim YS, Park SY,et al. CaMKⅡ regulates pericyte loss in the retina of early diabetic mouse[J].Mol Cells,2011,31(3):289-293. DOI: 10.1007/s10059-011-0038-2.
[9] Kobayashi K, Takahashi E, Miyagawa Y,et al. Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model[J].Neurosci Lett,2011,504(1):57-61.DOI:10.1016/j.neulet.2011.08.058.
[10] Sorge RE, Trang T, Dorfman R, et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity[J].Nat Med,2012,18(4):595-599.DOI:10.1038/nm.2710.
[11] Samways DS, Egan TM. Acidic amino acids impart enhanced Ca²⁺ permeability and flux in two members of the ATP-gated P2X receptor family[J].J Gen Physiol,2007,129(3):245-256.
[12] Clark AK, Wodarski R, Guida F,et al. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor[J].Glia,2010,58(14):1710-1726. DOI: 10.1002/glia.21042.
[13] Clark AK, Yip PK, Malcangio M. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S[J].J Neurosci,2009,29(21):6945-6954. DOI: 10.1523/JNEUROSCI.0828-09.2009.
[14] Migita K, Moriyama T, Koguchi M, et al. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy[J].Neurosci Lett,2009,452(2):200-203.DOI: 10.1016/j.neulet.2009.01.048.
[15] Ziegler D, Rathmann W, Dickhaus T,et al. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3[J].Pain Med,2009,10(2):393-400. DOI: 10.1111/j.1526-4637.2008.00555.x.
[16] Abbott CA, Malik RA, van Ross ER, et al. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K.[J].Diabetes Care,2011,34(10):2220-2224.DOI: 10.2337/dc11-1108.
[17] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中华内分泌代谢杂志, 2014, 30(10): 893-942.DOI: 10.3760/cma.j.issn.1000-6699.2014.10.020.
[18] He WJ, Cui J, Du L,et al. Spinal P2X(7)receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model[J].Behav Brain Res,2012,226(1):163-170. DOI: 10.1016/j.bbr.2011.09.015.

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

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