[1]孙荷平,许岚.嘌呤能受体P2X对痛性糖尿病神经病变的调控作用[J].国际内分泌代谢杂志,2016,36(04):269-272.[doi:10.3760/cma.j.issn.1673-4157.2016.04.14]
　Sun Heping,Xu Lan.The role of P2X receptors in painful diabetic neuropathy[J].International Journal of Endocrinology and Metabolism,2016,36(04):269-272.[doi:10.3760/cma.j.issn.1673-4157.2016.04.14]
点击复制

嘌呤能受体P2X对痛性糖尿病神经病变的调控作用()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年04期
页码:
269-272
栏目:
综述
出版日期:
2016-07-20

文章信息/Info

Title:
The role of P2X receptors in painful diabetic neuropathy
作者:
孙荷平; 许岚
214023 无锡,南京医科大学附属无锡市人民医院内分泌科
Author(s):
Sun Heping;  Xu Lan
Department of Endocrinology, The People's Hosphal of Wuxi, Nanjing Medical University, Wuxi 214023, China
关键词:
痛性糖尿病神经病变;  嘌呤受体;  信号转导通路
Keywords:
Painful diabetic neuropathy;  Purinergic receptor;  Signaling transduction pathways
DOI:
10.3760/cma.j.issn.1673-4157.2016.04.14
摘要:
痛性糖尿病神经病变(PDN)是糖尿病周围神经病变(DPN)的常见临床表现之一。目前PDN的发病机制尚不明确,现有的治疗方案有限且疗效欠佳。在初级传入感觉神经系统,P2X3受体在小直径背根神经节(DRG)神经元选择性高表达,高血糖通过诱导P2X3受体可塑性的改变来调控对疼痛的反应。在1型糖尿病模型小鼠中,P2X7受体可能通过调节神经递质的释放,使糖尿病小鼠产生机械痛敏。此外,也有研究报道其他P2X受体如P2X2、P2X4参与对PDN的调控。设计针对P2X受体的药物,可能是一种新的个体化治疗PDN的有效方法。
Abstract:
Painful diabetic neuropathy(PDN)is one of the most common clinic manifestation of diabetic peripheral neuropathy(DPN). The pathogenesis of PDN is not fully understood and current treatment options are limited and not satisfying. P2X3 receptor mostly expresses in the small-diameter dorsal root ganglion(DRG)neurons in primary afferent sensory nerve system. Hyperglycemia induces the change of P2X3 receptor's plasticity to adjust pain responses. In type 1 diabetes mellitus model mice, P2X7 receptor makes the diabetic mice produce mechanical pain sensitivity by releasing neurotransmitters. What's more, it has been reported that other P2X receptors such as P2X2 and P2X4 are involved in the regulation of PDN. Designing drugs against P2X receptors may be a new effective method of individualized treatment of PDN.

参考文献/References:

[1] Guariguata L, Whiting DR, Hambleton I, et al. Global estimates of diabetes prevalence for 2013 and projections for 2035[J]. Diabetes Res Clin Pract,2014,103(2):137-149. DOI: 10.1016/j.diabres.2013.11.002.
[2] Greig M, Tesfaye S, Selvarajah D, et al. Insights into the pathogenesis and treatment of painful diabetic neuropathy[J].Handb Clin Neurol,2014,126:559-578.DOI:10.1016/B978-0-444-53480-4.00037-0.
[3] Xu X, Chen H, Ling BY, et al. Extracellular signal-regulated protein kinase activation in spinal cord contributes to pain hypersensitivity in a mouse model of type 2 diabetes[J].Neurosci Bull,2014,30(1):53-66. DOI: 10.1007/s12264-013-1387-y.
[4] Migita K, Moriyama T, Koguchi M,et al. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy[J].Neurosci Lett,2009,452(2):200-203. DOI: 10.1016/j.neulet.2009.01.048.
[5] Xu GY, Li G, Liu N,et al. Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats[J].Mol Pain,2011,7:60.DOI:10.1186/1744-8069-7-60.
[6] Tuncay E, Zeydanli EN, Turan B. Cardioprotective effect of propranolol on diabetes-induced altered intracellular Ca2+ signaling in rat[J].J Bioenerg Biomembr,2011,43(6):747-756. DOI: 10.1007/s10863-011-9400-5.
[7] Kim YH, Kim YS, Kang SS, et al. Resveratrol inhibits neuronal apoptosis and elevated Ca2+/calmodulin-dependent protein kinase Ⅱ activity in diabetic mouse retina[J].Diabetes,2010,59(7):1825-1835. DOI: 10.2337/db09-1431.
[8] Kim YH, Kim YS, Park SY,et al. CaMKⅡ regulates pericyte loss in the retina of early diabetic mouse[J].Mol Cells,2011,31(3):289-293. DOI: 10.1007/s10059-011-0038-2.
[9] Kobayashi K, Takahashi E, Miyagawa Y,et al. Induction of the P2X7 receptor in spinal microglia in a neuropathic pain model[J].Neurosci Lett,2011,504(1):57-61.DOI:10.1016/j.neulet.2011.08.058.
[10] Sorge RE, Trang T, Dorfman R, et al. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity[J].Nat Med,2012,18(4):595-599.DOI:10.1038/nm.2710.
[11] Samways DS, Egan TM. Acidic amino acids impart enhanced Ca2+ permeability and flux in two members of the ATP-gated P2X receptor family[J].J Gen Physiol,2007,129(3):245-256.
[12] Clark AK, Wodarski R, Guida F,et al. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor[J].Glia,2010,58(14):1710-1726. DOI: 10.1002/glia.21042.
[13] Clark AK, Yip PK, Malcangio M. The liberation of fractalkine in the dorsal horn requires microglial cathepsin S[J].J Neurosci,2009,29(21):6945-6954. DOI: 10.1523/JNEUROSCI.0828-09.2009.
[14] Migita K, Moriyama T, Koguchi M, et al. Modulation of P2X receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy[J].Neurosci Lett,2009,452(2):200-203.DOI: 10.1016/j.neulet.2009.01.048.
[15] Ziegler D, Rathmann W, Dickhaus T,et al. Neuropathic pain in diabetes, prediabetes and normal glucose tolerance: the MONICA/KORA Augsburg Surveys S2 and S3[J].Pain Med,2009,10(2):393-400. DOI: 10.1111/j.1526-4637.2008.00555.x.
[16] Abbott CA, Malik RA, van Ross ER, et al. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K.[J].Diabetes Care,2011,34(10):2220-2224.DOI: 10.2337/dc11-1108.
[17] 中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2013年版)[J]. 中华内分泌代谢杂志, 2014, 30(10): 893-942.DOI: 10.3760/cma.j.issn.1000-6699.2014.10.020.
[18] He WJ, Cui J, Du L,et al. Spinal P2X(7)receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model[J].Behav Brain Res,2012,226(1):163-170. DOI: 10.1016/j.bbr.2011.09.015.

备注/Memo

备注/Memo:
通信作者:许岚,Email:xulanl26@126.com
更新日期/Last Update: 2016-09-20