[1]齐利琴,刘礼斌.GLP-1在2型糖尿病诱发的阿尔茨海默病治疗中的作用[J].国际内分泌代谢杂志,2016,36(01):48-51.[doi:10.3760/cma.j.issn.1673-4157.2016.01.012]
 Qi Liqin,Liu Libin..Effects of GLP-1 in the treatment of Alzheimer's disease induced by type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2016,36(01):48-51.[doi:10.3760/cma.j.issn.1673-4157.2016.01.012]
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GLP-1在2型糖尿病诱发的阿尔茨海默病治疗中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年01期
页码:
48-51
栏目:
综述
出版日期:
2016-01-20

文章信息/Info

Title:
Effects of GLP-1 in the treatment of Alzheimer's disease induced by type 2 diabetes mellitus
作者:
齐利琴刘礼斌
350001 福州,福建医科大学附属协和医院内分泌科,福建省内分泌研究所
Author(s):
Qi Liqin Liu Libin.
Institute of Endocrinology of Fujian Province,Department of Endocrinology,The Union Hospital Affiliated to Fujian Medical University,Fuzhou 350001,China
关键词:
胰高血糖素样肽-1 2型糖尿病 阿尔茨海默病
Keywords:
Glucagon-like peptide-1 Type 2 diabetes mellitus Alzheimer's disease
DOI:
10.3760/cma.j.issn.1673-4157.2016.01.012
摘要:
2型糖尿病是诱发阿尔茨海默病的高危因素。胰高血糖素样肽-1(GLP-1)可诱导胰岛β细胞再生和增殖,可以呈葡萄糖依赖性地促进胰岛素分泌。另外,GLP-1 在治疗神经退行性病变中也有重要的作用,能降低脑内β淀粉样蛋白斑块沉积,减少氧化应激引起的神经细胞损伤,还可以调节突触的传递,增加突触的可塑性,刺激轴突生长,影响长时程增强,从而改善记忆并提高认知水平。
Abstract:
Type 2 diabetes has been identified as a risk factor for Alzheimer's disease(AD). Glucagon-like peptide-1(GLP-1)can stimulate β cell proliferation and insulin secretion in a glucose-dependent manner. It has been shown that GLP-1 also plays important roles in the treatment of neurodegenerative disease,such as reversing the detrimental effects that β-amyloid plaque load in brain, preventing neurons from oxidative damage, modulating synaptic transmission, rescuing synaptic plasticity, stimulating neurite growth, and affecting the process of long-term potentiation. Thus it can improve memory and cognitive dysfunction.

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更新日期/Last Update: 2016-01-20