[1]马静茹,牟新.表观遗传学与糖尿病肾病[J].国际内分泌代谢杂志,2016,36(01):52-54.[doi:10.3760/cma.j.issn.1673-4157.2016.01.013]
 Ma Jingru*,Mou Xin..Epigenetics and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2016,36(01):52-54.[doi:10.3760/cma.j.issn.1673-4157.2016.01.013]
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表观遗传学与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年01期
页码:
52-54
栏目:
综述
出版日期:
2016-01-20

文章信息/Info

Title:
Epigenetics and diabetic nephropathy
作者:
马静茹牟新
310000 杭州,浙江中医药大学(马静茹); 310000 杭州市红十字会医院(牟新)
Author(s):
Ma Jingru*Mou Xin.
*Zhejiang Chinese Medical University, Hangzhou 310000,China
关键词:
表观遗传学 糖尿病肾病 基因
Keywords:
Epigenetics Diabetic nephropathy Genes
DOI:
10.3760/cma.j.issn.1673-4157.2016.01.013
摘要:
表观遗传调控主要包括DNA甲基化、组蛋白修饰和微小RNA(miRNA)等。糖尿病肾病(DN)是糖尿病主要的慢性并发症之一。一些特定基因的启动子区甲基化水平异常,组蛋白乙酰化与去乙酰化及miRNA等都参与了DN的发生、发展。对表观遗传学与DN关系的研究,可为进一步认识和治疗DN提供一种新的途径。
Abstract:
Epigenetic regulations include DNA methylation, histone modifications and microRNA(miRNA), etc. Diabetic nephropathy(DN)is one of the major chronic complications of diabetes.Abnormal levels of some specific gene promoter region methylation, and acetylation of histone acetylation and microRNAs are involved in the occurrence and development of DN. Further research of the relationship between epigenetics and DN could provide a new approach for the treatment of DN.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(30801467,81273623); 浙江省科技厅项目(2013C33212); 中国博士后科学基金(2014M551775)
更新日期/Last Update: 2016-01-20