[1]翟丽敏,叶山东.二甲双胍的抗炎作用及其糖尿病肾脏保护作用[J].国际内分泌代谢杂志,2014,(05):334-336.[doi:10.3760/cma.j.issn.1673-4157.2014.05.013]
 Zhai Limin,Ye Shandong..Anti-inflammatory effects of metformin and its renal protection in diabetes[J].International Journal of Endocrinology and Metabolism,2014,(05):334-336.[doi:10.3760/cma.j.issn.1673-4157.2014.05.013]
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二甲双胍的抗炎作用及其糖尿病肾脏保护作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
334-336
栏目:
综述
出版日期:
2014-10-31

文章信息/Info

Title:
Anti-inflammatory effects of metformin and its renal protection in diabetes
作者:
翟丽敏叶山东
230001 合肥,安徽医科大学附属省立医院内分泌科
Author(s):
Zhai LiminYe Shandong.
Department of Endocrinology,Anhui Provincial Hospital Affiliated to Anhui Medical University,Hefei 230001,China Corresponding author:Ye Shandong,Email:ysdl96406@163.com
关键词:
二甲双胍 糖尿病肾病 炎症 氧化应激
Keywords:
Metformin Diabetic nephropathy Inflammation Oxidative stress
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.013
摘要:
炎性反应在糖尿病肾病(DN)的发生、发展中起重要作用。高糖作为始动因素,与晚期糖基化终末产物(AGEs)、氧化应激及肾内血流动力学的改变共同引起了糖尿病肾脏炎性反应的发生。而二甲双胍作为治疗糖尿病的一线药物,近年研究显示其除降糖作用以外,还可通过激活腺苷酸活化蛋白激酶(AMPK)、抗氧化应激和改善胰岛素抵抗等机制发挥抗炎作用,从而预防和延缓DN的发生和发展。
Abstract:
Inflammation plays an important role in the occurrence and development of diabetic nephropathy(DN). Hyperglycemia as the initiating factor, combined with advanced glycosylation end products(AGEs), oxidative stress and the renal hemodynamic changes causes a inflammation in diabetic renal tissue. Except the hypoglycemic effect, metformin, as the first-line drugs for the treatment of diabetes,can prevent and delay the occurrence and progress of DN through some anti-inflammatory mechanisms,which include activation of the AMP activated protein kinase(AMPK),anti-oxidative stress and improvement of insulin resistance.

参考文献/References:

[1] Luis-Rodríguez D, Martínez-Castelao A, Górriz JL, et al. Pathophysiological role and therapeutic implications of inflammation in diabetic nephropathy[J].World J Diabetes, 2012,3(1):7-18.
[2] Niewczas MA, Ficociello LH, Johnson AC, et al. Serum concentrations of markers of TNFalpha and Fas-mediated pathways and renal function in nonproteinuric patients with type 1 diabetes[J].Clin J Am Soc Nephrol, 2009,4(1):62-70.
[3] Shelbaya S, Amer H, Seddik S, et al. Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabetic nephropathy in type 1 diabetic patients[J].Eur Rev Med Pharmacol Sci, 2012,16(2):176-182.
[4] Rüster C, Bondeva T, Franke S, et al.Angiotensin Ⅱ upregulates RAGE expression on podocytes: role of AT2 receptors[J].Am J Nephrol, 2009,29(6):538-550.
[5] Sanchez-Ni?o MD, Sanz AB, Ihalmo P, et al. The MIF receptor CD74 in diabetic podocyte injury[J].J Am Soc Nephrol, 2009,20(2):353-362.
[6] Lewko B, Stepinski J.Hyperglycemia and mechanical stress: targeting the renal podocyte[J].J Cell Physiol, 2009,221(2):288-295.
[7] Yan SF, Yan SD, Ramasamy R, et al. Tempering the wrath of RAGE: an emerging therapeutic strategy against diabetic complications, neurodegeneration, and inflammation[J].Ann Med, 2009,41(6):408-422.
[8] Ishibashi Y, Matsui T, Takeuchi M, et al. Metformin inhibits advanced glycation end products(AGEs)-induced renal tubular cell injury by suppressing reactive Oxygen species Generation via reducing receptor for AGEs(RAGE)expression[J].Horm Metab Res, 2012,44(12):891-895.
[9] Ramasamy R,Yan SF,Schmidt AM. Receptor for AGE(RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications[J].Ann N Y Acad Sci, 2011,1243:88-102.
[10] Sourris KC, Forbes JM. Interactions between advanced glycation end-products(AGE)and their receptors in the development and progression of diabetic nephropathy- are these receptors valid therapeutic targets[J].Curr Drug Targets, 2009,10(1):42-50.
[11] Louro TM, Matafome PN, Nunes EC, et al. Insulin and metformin May prevent renal injury in young type 2 diabetic Goto-Kakizaki rats[J].Eur J Pharmacol, 2011,653(1/3):89-94.
[12] Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, et al. Metformin against TGFβ-induced epithelial-to-mesenchymal transition(EMT): from Cancer stem cells to aging-associated fibrosis[J].Cell Cycle, 2010,9(22):4461-4468.
[13] Alhaider AA, Korashy HM, Sayed-Ahmed MM, et al. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression[J].Chem Biol Interact, 2011,192(3):233-242.
[14] Andrews M, Soto N, Arredondo M. Effect of metformin on the expression of tumor necrosis factor-alpha, Toll like receptors 2/4 and C reactive protein in obese type-2 diabetic patients[J].Rev Med Chil,2012, 140(11): 1377-1382.
[15] Krysiak R, Okopien B. The effect of metformin on monocyte secretory function in simvastatin-treated patients with impaired fasting glucose[J].Metabolism, 2013,62(1):39-43.
[16] Hawley SA, Ross FA, Chevtzoff C, et al. Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation[J].Cell Metab, 2010,11(6):554-565.
[17] Ouyang J, Parakhia RA, Ochs RS. Metformin activates AMP kinase through inhibition of AMP deaminase[J].J Biol Chem, 2011,286(1):1-11.
[18] 姚烽,汲广岩,张力.腺苷酸活化蛋白激酶:炎症调控新靶点[J].生理学报, 2012,64(3):341-345.
[19] Isoda K, Young JL, Zirlik A, et al. Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells[J].Arterioscler Thromb Vasc Biol, 2006,26(3):611-617.
[20] Hattori Y, Suzuki K, Hattori S, et al. Metformin inhibits cytokine-induced nuclear factor kappaB activation via AMP-activated protein kinase activation in vascular endothelial cells[J].Hypertension, 2006,47(6):1183-1188.
[21] Viollet B, Guigas B, Sanz Garcia N, et al. Cellular and molecular mechanisms of metformin: an overview[J].Clin Sci(Lond), 2012,122(6):253-270.
[22] Morales AI, Detaille D, Prieto M, et al. Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway[J].Kidney Int, 2010,77(10):861-869.
[23] Piwkowska A, Rogacka D, Jankowski M, et al. Metformin induces suppression of NAD(P)H oxidase activity in podocytes[J].Biochem Biophys Res Commun, 2010,393(2):268-273.
[24] Ishibashi Y, Matsui T, Takeuchi M, et al. Beneficial effects of metformin and irbesartan on advanced glycation end products(AGEs)-RAGE-induced proximal tubular cell injury[J].Pharmacol Res, 2012,65(3):297-302.
[25] Alhaider AA, Korashy HM, Sayed-Ahmed MM, et al. Metformin attenuates streptozotocin-induced diabetic nephropathy in rats through modulation of oxidative stress genes expression[J].Chem Biol Interact, 2011,192(3):233-242.
[26] Mao XM, Liu H, Tao XJ, et al. Independent anti-inflammatory effect of insulin in newly diagnosed type 2 diabetes[J].Diabetes Metab Res Rev, 2009,25(5):435-441.

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备注/Memo

备注/Memo:
通信作者:叶山东,Email:ysd196406@163.com
更新日期/Last Update: 2014-09-20