[1]王丹,关美萍,薛耀明.早期生长反应因子-1与糖尿病肾病[J].国际内分泌代谢杂志,2014,(06):397-400.[doi:10.3760/cma.j.issn.1673-4157.2014.06.010]
 Wang Dan,Guan Meiping,Xue Yaoming..Early growth response factor-1 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2014,(06):397-400.[doi:10.3760/cma.j.issn.1673-4157.2014.06.010]
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早期生长反应因子-1与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年06期
页码:
397-400
栏目:
综述
出版日期:
2014-12-20

文章信息/Info

Title:
Early growth response factor-1 and diabetic nephropathy
作者:
王丹关美萍薛耀明
510515 广州,南方医科大学南方医院内分泌代谢科
Author(s):
Wang Dan Guan Meiping Xue Yaoming.
Department of Endocrinology and Metabolism, Nanfang Hospital, Southern Medical University, Guangzhou 510515,China
关键词:
早期生长反应因子-1 糖尿病肾病 肾纤维化
Keywords:
Early growth response factor-1 Diabetic nephropathy Renal fibrosis
DOI:
10.3760/cma.j.issn.1673-4157.2014.06.010
摘要:
早期生长反应因子-1(Egr-1)是一种具有锌指结构的转录因子,能被多种刺激因素诱导,并能调控下游多种基因的表达,参与细胞的生长、分化、增殖和凋亡。研究发现,高血糖可引起肾脏Egr-1表达增加,促进系膜细胞增殖、血管内皮功能损伤、细胞外基质积聚、转化生长因子-β过表达和肾纤维化,表明Egr-1与糖尿病肾病的发生、发展密切相关。
Abstract:
Early growth response factor-1(Egr-1)is a zinc finger transcription factor, which can be induced by a variety of stimulus and can also regulate the expression of multiple downstream genes. Egr-1 involves in cell growth, differentiation,proliferation and apoptosis. Studies have found that hyperglycemia can lead to an increase of Egr-1 expression which contributes to mesangial cells proliferation,endothelial dysfunction,extracellular matrix accumulating, overexpression of transformation growth factor-β and renal fibrosis. Therefore Egr-1 is closely related to the development and progression of diabetic nephropathy.

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备注/Memo

备注/Memo:
基金项目:广东省级产业技术研究与开发专项(粤财工[2010]207)
更新日期/Last Update: 2014-12-20