[1]于菁 王秋月.多聚ADP核糖聚合酶-1与糖尿病肾病[J].国际内分泌代谢杂志,2015,(06):409-412.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.013]
 Yu Jing,Wang Qiuyue..Poly(ADP-ribose)polymerase-1 and diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(06):409-412.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.013]
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多聚ADP核糖聚合酶-1与糖尿病肾病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年06期
页码:
409-412
栏目:
基础研究
出版日期:
2015-11-20

文章信息/Info

Title:
Poly(ADP-ribose)polymerase-1 and diabetic nephropathy
作者:
于菁 王秋月
110001 沈阳,中国医科大学附属第一医院内分泌科
Author(s):
Yu Jing Wang Qiuyue.
Department of Endocrinology, The First Hospital,China Medical University, Shenyang 110001,China
关键词:
多聚ADP核糖聚合酶-1 糖尿病肾病
Keywords:
Poly(ADP-ribose)polymerase-1 Diabetic nephropathy
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.06.013
摘要:
多聚ADP核糖聚合酶-1(PARP-1)是多聚ADP核糖聚合酶家族中重要的成员之一,在肾组织中广泛表达。近期研究发现,PARP-1与糖尿病肾病的发生、发展关系密切,PARP-1通过加重高糖氧化应激、促进慢性低度炎性反应、抑制组蛋白脱乙酰酶-1 活性、增强Toll样受体4活性、上调内皮素及内皮素受体的表达、诱导纤溶系统紊乱等参与糖尿病肾病的病理生理过程。而相关研究也证明PARP-1抑制剂在糖尿病肾病的发病过程中可起到一定的保护作用,故PAPR-1可能成为糖尿病肾病的新治疗靶点。
Abstract:
As one of the important members of the poly(ADP-ribose)polymerase family, poly(ADP-ribose)polymerase-1(PARP-1)is abundantly expressed in renal tissue. Recent studies have shown that there is a close relationship between PARP-1 and diabetic nephropathy. PARP-1 is involved in the pathologic process of diabetic nephropathy by increasing oxidative stress, promoting chronic low-grade inflammation, inhibiting Sirtuin-1 activity, enhancing Toll like receptor 4 activity, boosting endothelin and endothelial receptor as well as disordering fibrinolysis system. Related studies also have shown that PARP-1 inhibitors may play protective roles in the pathogenesis of diabetic nephropathy, which may be a new therapeutic target for diabetic nephropathy.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:辽宁省高等学校“高端人才队伍建设工程”(2014187); 2011年辽宁省“百千万人才工程”资助项目(2011377); 辽宁省科技攻关计划项目(2011225017) 作者单位:110001 沈阳,中国医科大学附属第一医院内分泌科 通信作者:王秋月,Email:wqycmu@163.com
更新日期/Last Update: 2015-11-20