[1]林杨 叶山东.二甲双胍对糖尿病肾病保护作用的机制[J].国际内分泌代谢杂志,2018,38(01):52-54.[doi:10.3760/cma.j.issn.1673-4157.2018.01.014]
 Lin Yang*,Ye Shandong. *.Protective effects of metformin on diabetic nephropathy and its mechanism[J].International Journal of Endocrinology and Metabolism,2018,38(01):52-54.[doi:10.3760/cma.j.issn.1673-4157.2018.01.014]
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二甲双胍对糖尿病肾病保护作用的机制()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年01期
页码:
52-54
栏目:
综述
出版日期:
2018-01-20

文章信息/Info

Title:
Protective effects of metformin on diabetic nephropathy and its mechanism
作者:
林杨 叶山东
233001 合肥,中国科学技术大学附属第一医院,安徽省立医院儿科(林杨),内分泌科(叶山东)
Author(s):
Lin Yang*Ye Shandong. *
Department of Pediatrics, The First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital,Hefei 230001,China
关键词:
二甲双胍 糖尿病肾病 炎症 氧化应激
Keywords:
Metformin Diabetic nephropathy Inflammation Oxidative stress
DOI:
10.3760/cma.j.issn.1673-4157.2018.01.014
摘要:
二甲双胍是治疗糖尿病的一线药物,很多研究已经证实,二甲双胍具有降糖之外的肾脏保护作用,相关机制包括抗炎、抗氧化、缓解肾脏的缺氧和能量消耗,抑制肾脏肥大和减轻肾脏脂质沉积等,从而预防和延缓糖尿病肾病(DN)的发生和发展,为DN的防治提供新的治疗方法,其确切机制仍需进一步探讨。
Abstract:
Metformin is a first-line drug for the treatment of diabetes, many studies have confirmed that metformin has a protective effect on kidney through anti-inflammatory, anti-oxidative stress,alleviation of the renal hypoxia and energy consumption, inhibition of renal hypertrophy and lightening renal lipid deposition,which is independent of its hypoglycemic effect.So metformin can prevent and delay the occurrence and development of diabetic nephropathy. The mechanism remains to be exploded.

参考文献/References:


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备注/Memo

备注/Memo:

通信作者:叶山东,Email:ysd196406@163.com
更新日期/Last Update: 2018-01-30