参考文献/References:
[1] Ingelfinger JR,Jarcho JA.Increase in the incidence of diabetes and its implications[J].N Engl J Med,2017,376(15):1473-1474.DOI:10.1056/NEJMe1616575.
[2] Diamant M,Nieuwland R,Pablo RF,et al.Elevated numbers of tissue-factor exposing microparticles correlate with components of the metabolic syndrome in uncomplicated type 2 diabetes mellitus[J].Circulation,2002,106(19):2442-2447.
[3] Trams EG,Lauter CJ,Salem N Jr,et al.Exfoliation of membrane ecto-enzymes in the form of micro-vesicles[J].Biochim Biophys Acta,1981,645(1):63-70.
[4] Johnstone RM,Adam M,Hammond JR,et al.Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles(exosomes)[J].J Biol Chem,1987,262(19):9412-9420.
[5] Lakhter AJ,Sims EK.Minireview: emerging roles for extracellular vesicles in diabetes and related metabolic disorders[J].Mol Endocrinol,2015,29(11):1535-1548. DOI:10.1210/me.2015-1206.
[6] Colombo M,Raposo G,Théry C.Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles[J].Annu Rev Cell Dev Biol,2014,30:255-289.DOI:10.1146/annurev-cellbio-101512-122326.
[7] Hanson PI,Cashikar A.Multivesicular body morphogenesis[J].Annu Rev Cell Dev Biol,2012,28:337-362.DOI:10.1146/annurev-cellbio-092910-154152.
[8] Mazurov D,Barbashova L,Filatov A.Tetraspanin protein CD9 interacts with metalloprotease CD10 and enhances its release via exosomes[J].FEBS J,2013,280(5):1200-1213.DOI:10.1111/febs.12110.
[9] Trajkovic K,Hsu C,Chiantia S,et al.Ceramide triggers budding of exosome vesicles into multivesicular endosomes[J].Science,2008,319(5867):1244-1247.DOI:10.1126/science.1153124.
[10] Hyenne V,Labouesse M,Goetz JG.The small GTPase Ral orchestrates MVB biogenesis and exosome secretion[J].Small GTPases,2016,22:1-7.DOI:10.1080/21541248.2016.1251378.
[11] Sinha S,Hoshino D,Hong NH,et al.Cortactin promotes exosome secretion by controlling branched actin dynamics[J].J Cell Biol,2016,214(2):197-213.DOI:10.1083/jcb.201601025.
[12] Bobrie A,Colombo M,Raposo G,et al.Exosome secretion: molecular mechanisms and roles in immune responses[J].Traffic,2011,12(12):1659-1668.DOI:10.1111/j.1600-0854.2011.01225.x.
[13] Robbins PD,Morelli AE. Regulation of immune responses by extracellular vesicles[J].Nat Rev Immunol,2014,14(3):195-208.DOI:10.1038/nri3622.
[14] Cai Z,Yang F,Yu L,et al.Activated T cell exosomes promote tumor invasion via Fas signaling pathway[J].J Immunol,2012,188(12):5954-5961.DOI:10.4049/jimmunol.1103466.
[15] Chivet M,Hemming F,Pernet-Gallay K,et al.Emerging role of neuronal exosomes in the central nervous system[J].Front Physiol,2012,3:145.DOI:10.3389/fphys.2012.00145.
[16] Quesenberry PJ,Aliotta JM.Cellular phenotype switching and microvesicles[J].Adv Drug Deliv Rev,2010,62(12):1141-1148.DOI:10.1016/j.addr.2010.06.001.
[17] Timmers L,Lim SK,Hoefer IE,et al.Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction[J].Stem Cell Res,2011,6(3):206-214.DOI:10.1016/j.scr.2011.01.001.
[18] Teng Y,Ren Y,Hu X,et al.MVP-mediated exosomal sorting of miR-193a promotes colon cancer progression[J].Nat Commun,2017,8:14448.DOI:10.1038/ncomms14448.
[19] Lee MJ,Park DH,Kang JH.Exosomes as the source of biomarkers of metabolic diseases[J].Ann Pediatr Endocrinol Metab,2016,21(3):119-125.DOI:10.6065/apem.2016.21.3.119.
[20] Koeck ES,Iordanskaia T,Sevilla S,et al.Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes: a novel paradigm for obesity-related liver disease[J].J Surg Res,2014,192(2):268-275.DOI:10.1016/j.jss.2014.06.050.
[21] Cianciaruso C,Phelps EA,Pasquier M,et al.Primary human and Rat β-cells release the intracellular autoantigens GAD65, IA-2, and proinsulin in exosomes together with cytokine-induced enhancers of immunity[J].Diabetes,2017,66(2):460-473.DOI:10.2337/db16-0671.
[22] Eizirik DL,Cardozo AK,Cnop M.The role for endoplasmic reticulum stress in diabetes mellitus[J].Endocr Rev,2008,29(1):42-61.DOI:10.1210/er.2007-0015.
[23] Rahman MJ,Regn D,Bashratyan R,et al.Exosomes released by islet-derived mesenchymal stem cells trigger autoimmuneresponses in NOD mice[J].Diabetes,2014,63(3):1008-1020.DOI:10.2337/db13-0859.
[24] Sheng H,Hassanali S,Nugent C,et al.Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice[J].J Immunol,2011,187(4):1591-1600.DOI:10.4049/jimmunol.1100231.
[25] Osmai M,Osmai Y,Bang-Berthelsen CH,et al.MicroRNAs as regulators of beta-cell function and dysfunction[J].Diabetes Metab Res Rev,2016,32(4):334-349.DOI:10.1002/dmrr.2719.
[26] Guay C,Jacovetti C,Nesca V,et al.Emerging roles of non-coding RNAs in pancreatic β-cell function and dysfunction[J].Diabetes Obes Metab,2012,14(Suppl 3):12-21.DOI:10.1111/j.1463-1326.2012.01654.x.
[27] Guay C,Menoud V,Rome S,et al.Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells[J].Cell Commun Signal,2015,13:17.DOI:10.1186/s12964-015-0097-7.
[28] Guilherme A,Virbasius JV,Puri V,et al.Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes[J].Nat Rev Mol Cell Biol,2008,9(5):367-377.DOI:10.1038/nrm2391.
[29] Deng ZB,Poliakov A,Hardy RW,et al.Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance[J].Diabetes,2009,58(11):2498-2505.DOI:10.2337/db09-0216.
[30] Uysal KT,Scheja L,Wiesbrock SM,et al.Improved glucose and lipid metabolism in genetically obese mice lacking aP2[J].Endocrinology,2000,141(9):3388-3396.DOI:10.1210/endo.141.9.7637.
[31] Ertunc ME,Sikkeland J,Fenaroli F,et al.Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity[J].J Lipid Res,2015,56(2):423-434.DOI:10.1194/jlr.M055798.
[32] Lawson C,Vicencio JM,Yellon DM,et al.Microvesicles and exosomes: new players in metabolic and cardiovascular disease[J].J Endocrinol,2016,228(2):R57-R71.DOI:10.1530/JOE-15-0201.
相似文献/References:
[1]李春睿,王静,陈峰,等.GLP-1受体激动剂对糖尿病患者肾功能的影响[J].国际内分泌代谢杂志,2014,(06):401.[doi:10.3760/cma.j.issn.1673-4157.2014.06.011]
Li Chunrui*,Wang Jing,Chen Feng,et al.Effects of GLP-1 receptor agonists on renal function of diabetics[J].International Journal of Endocrinology and Metabolism,2014,(02):401.[doi:10.3760/cma.j.issn.1673-4157.2014.06.011]
[2]黄珊珊,鲁一兵.长链非编码RNA与糖尿病[J].国际内分泌代谢杂志,2015,(04):271.[doi:10.3760/cma.j.issn.1673-4157.2015.04.016]
Huang Shanshan*,Lu Yibing..Long non-coding RNA and diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(02):271.[doi:10.3760/cma.j.issn.1673-4157.2015.04.016]
[3]高瑞霄,姚朱华,冯凭,等.尿8-羟基脱氧鸟苷在2型糖尿病及糖尿病合并冠心病患者中的临床意义[J].国际内分泌代谢杂志,2014,(05):295.[doi:10.3760/cma.j.issn.1673-4157.2014.05.002]
Gao Ruixiao*,Yao Zhuhua,Feng Ping,et al.The clinical significance of urinary 8-hydroxy deoxyguanosine in patients with type 2 diabetes mellitus and diabetic patients with coronary heart disease[J].International Journal of Endocrinology and Metabolism,2014,(02):295.[doi:10.3760/cma.j.issn.1673-4157.2014.05.002]
[4]郑佳,肖新华.葡萄糖稳态的中枢调控作用机制
——2014年美国糖尿病协会“杰出科学成就奖”
演讲报告解读[J].国际内分泌代谢杂志,2014,(05):305.[doi:10.3760/cma.j.issn.1673-4157.2014.05.004]
Zheng Jia,Xiao Xinhua.The mechanisms of central nervous system in the control of glucose homeostasis--A summary of 2014 ADA "Outstanding Scientific Achievement Award" Lecture[J].International Journal of Endocrinology and Metabolism,2014,(02):305.[doi:10.3760/cma.j.issn.1673-4157.2014.05.004]
[5]唐勤,邵莉.蛋白乙酰化与胰岛素分泌[J].国际内分泌代谢杂志,2014,(05):313.[doi:10.3760/cma.j.issn.1673-4157.2014.05.007]
Tang Qin,Shao Li..Protein acetylation and insulin secretion[J].International Journal of Endocrinology and Metabolism,2014,(02):313.[doi:10.3760/cma.j.issn.1673-4157.2014.05.007]
[6]卢婷婷,任思佳,沈捷.人群迁徙对糖尿病患病率的影响及其相关因素[J].国际内分泌代谢杂志,2014,(05):327.[doi:10.3760/cma.j.issn.1673-4157.2014.05.011]
Lu Tingting,Ren Sijia,Shen Jie..Impact of migration on prevalence of diabetes and risk factors[J].International Journal of Endocrinology and Metabolism,2014,(02):327.[doi:10.3760/cma.j.issn.1673-4157.2014.05.011]
[7]包薇萍,陈国芳,刘超.DPP-4抑制剂的肾保护作用[J].国际内分泌代谢杂志,2014,(05):337.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
Bao Weiping,Chen Guofang,Liu Chao..Renal protective effects of dipeptidyl peptidase-4 inhibitors[J].International Journal of Endocrinology and Metabolism,2014,(02):337.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
[8]孟庆冬,陶红.巨噬细胞凋亡与糖尿病动脉粥样硬化[J].国际内分泌代谢杂志,2014,(05):340.[doi:10.3760/cma.j.issn.1673-4157.2014.05.015]
Meng Qingdong,Tao Hong..Macrophage apoptosis and diabetic atherosclerosis[J].International Journal of Endocrinology and Metabolism,2014,(02):340.[doi:10.3760/cma.j.issn.1673-4157.2014.05.015]
[9]赵荷珺 洪天配.胰高血糖素样肽-1类药物与胰腺安全性[J].国际内分泌代谢杂志,2015,(05):319.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.008]
Zhao Hejun*,Hong Tianpei..Glucagon-like peptide-1-based therapies and pancreatic safety[J].International Journal of Endocrinology and Metabolism,2015,(02):319.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.008]
[10]吕丹 李晓思 陈树春 王泽普.Betatrophin:糖尿病再生治疗的新希望[J].国际内分泌代谢杂志,2015,(05):351.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.016]
Lyu Dan*,Li Xiaosi,Chen Shuchun,et al.Betatrophin:new hope for regeneration therapy of diabetes[J].International Journal of Endocrinology and Metabolism,2015,(02):351.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.016]