[1]陈蕊华,彭永德.肠道菌群及其代谢产物与糖尿病性认知功能减退症关系的研究进展[J].国际内分泌代谢杂志,2022,42(03):211-214.[doi:10.3760/cma.j.cn121383-20210105-01012]
 Chen Ruihua,Peng Yongde..Associations of intestinal flora and its metabolites with diabetes-related cognitive dysfunction[J].International Journal of Endocrinology and Metabolism,2022,42(03):211-214.[doi:10.3760/cma.j.cn121383-20210105-01012]
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肠道菌群及其代谢产物与糖尿病性认知功能减退症关系的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年03期
页码:
211-214
栏目:
综述
出版日期:
2022-05-20

文章信息/Info

Title:
Associations of intestinal flora and its metabolites with diabetes-related cognitive dysfunction
作者:
陈蕊华彭永德
上海交通大学附属第一人民医院内分泌代谢科 200080
Author(s):
Chen Ruihua Peng Yongde.
Department of Endocrinology and Metabolism, Shanghai General Hospital of Shanghai Jiaotong University, Shanghai 200080, China
关键词:
肠道菌群 糖尿病 认知功能障碍
Keywords:
Gut microbiota Diabetes mellitus Cognitive impairment
DOI:
10.3760/cma.j.cn121383-20210105-01012
摘要:
糖尿病患者发生认知功能减退和痴呆的风险显著升高。近年来的研究显示,肠道菌群失调及其代谢产物的水平变化可能与糖尿病的发生和患者出现认知功能减退及痴呆密切相关。它们可能通过肠-脑轴调节中枢神经系统,影响中枢神经系统的代谢和认知水平。深入了解肠道菌群及其代谢产物对糖尿病患者代谢和中枢系统的影响及其与认知功能的联系,有助于更好地指导糖尿病相关认知功能障碍的防治。
Abstract:
Diabetes is highly associated with mild cognitive impairment(MCI)and dementia. Recent studies have shown that intestinal flora imbalance and changes of its metabolites may be closely related to the occurrence of diabetes, cognitive decline and dementia. They may regulate the central nervous system via the gut-brain axis, thereby affecting the metabolism and cognitive function of the central nervous system. An in-depth understanding of the influence of the intestinal flora and its metabolites on central system of diabetic patients and its connection with cognitive function will help to guide better clinical prevention and intervention of diabetes-related cognitive dysfunction.

参考文献/References:

[1] De Vadder F,Kovatcheva-Datchary P,Goncalves D,et al.Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits[J].Cell,2014,156(1-2):84-96.DOI:10.1016/j.cell.2013.12.016.
[2] Zhang J,Chen C,Hua S,et al.An updated meta-analysis of cohort studies:diabetes and risk of Alzheimer's disease[J].Diabetes Res Clin Pract,2017,124:41-47.DOI:10.1016/j.diabres.2016.10.024.
[3] Biessels GJ,Despa F.Cognitive decline and dementia in diabetes mellitus:mechanisms and clinical implications[J].Nat Rev Endocrinol,2018,14(10):591-604.DOI:10.1038/s41574-018-0048-7.
[4] Ma Q,Li Y,Li P,et al.Research progress in the relationship between type 2 diabetes mellitus and intestinal flora[J].Biomed Pharmacother,2019,117:109138.DOI:10.1016/j.biopha.2019.109138.
[5] Qin J,Li Y,Cai Z,et al.A metagenome-wide association study of gut microbiota in type 2 diabetes[J].Nature,2012,490(7418):55-60.DOI:10.1038/nature11450.
[6] Heiss CN,Olofsson LE.Gut Microbiota-Dependent Modulation of Energy Metabolism[J].J Innate Immun,2018,10(3):163-171.DOI:10.1159/000481519.
[7] Matey-Hernandez ML,Williams FMK,Potter T,et al.Genetic and microbiome influence on lipid metabolism and dyslipidemia[J].Physiol Genomics,2018,50(2):117-126.DOI:10.1152/physiolgenomics.00053.2017.
[8] Camargo A,Jimenez-Lucena R,Alcala-Diaz JF,et al.Postprandial endotoxemia may influence the development of type 2 diabetes mellitus:From the CORDIOPREV study[J].Clin Nutr,2019,38(2):529-538.DOI:10.1016/j.clnu.2018.03.016.
[9] Clemmensen C,Müller TD,Woods SC,et al.Gut-Brain Cross-Talk in Metabolic Control[J].Cell,2017,168(5):758-774.DOI:10.1016/j.cell.2017.01.025.
[10] Westfall S,Lomis N,Kahouli I,et al.Microbiome,probiotics and neurodegenerative diseases:deciphering the gut brain axis[J].Cell Mol Life Sci,2017,74(20):3769-3787.DOI:10.1007/s00018-017-2550-9.
[11] Wang X,Wang F,Zhang Y,et al.Diabetic cognitive dysfunction is associated with increased bile acids in liver and activation of bile acid signaling in intestine[J].Toxicol Lett,2018,287:10-22.DOI:10.1016/j.toxlet.2018.01.006.
[12] Zhang J,Zhang Y,Yuan Y,et al.Gut microbiota alteration is associated with cognitive deficits in genetically diabetic(Db/db)mice during aging[J].Front Aging Neurosci,2021,13:815562.DOI:10.3389/fnagi.2021.815562.
[13] Liu P,Wu L,Peng G,et al.Altered microbiomes distinguish Alzheimer's disease from amnestic mild cognitive impairment and health in a Chinese cohort[J].Brain Behav Immun,2019,80:633-643.DOI:10.1016/j.bbi.2019.05.008.
[14] Zhang Y,Lu S,Yang Y,et al.The diversity of gut microbiota in type 2 diabetes with or without cognitive impairment[J].Aging Clin Exp Res,2021,33(3):589-601.DOI:10.1007/s40520-020-01553-9.
[15] Dalile B,Van Oudenhove L,Vervliet B,et al.The role of short-chain fatty acids in microbiota-gut-brain communication[J].Nat Rev Gastroenterol Hepatol,2019,16(8):461-478.DOI:10.1038/s41575-019-0157-3.
[16] Zhao L,Zhang F,Ding X,et al.Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes[J].Science,2018,359(6380):1151-1156.DOI:10.1126/science.aao5774.
[17] Verhaar BJH,Hendriksen HMA,de Leeuw FA,et al.Gut Microbiota Composition Is Related to AD Pathology[J].Front Immunol,2022,12:794519.DOI:10.3389/fimmu.2021.794519.
[18] Stilling RM,Van de Wouw M,Clarke G,et al.The neuropharmacology of butyrate:The bread and butter of the microbiota-gut-brain axis?[J].Neurochem Int,2016,99:110-132.DOI:10.1016/j.neuint.2016.06.011.
[19] Xu Y,Zhou H,Zhu Q.The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment[J].Front Aging Neurosci,2017,9:106.DOI:10.3389/fnagi.2017.00106.
[20] Elia AE,Lalli S,Monsurrò MR,et al.Tauroursodeoxycholic acid in the treatment of patients with amyotrophic lateral sclerosis[J].Eur J Neurol,2016,23(1):45-52.DOI:10.1111/ene.12664.
[21] Wu X,Liu C,Chen L,et al.Protective effects of tauroursodeoxycholic acid on lipopolysaccharide-induced cognitive impairment and neurotoxicity in mice[J].Int Immunopharmacol,2019,72:166-175.DOI:10.1016/j.intimp.2019.03.065.
[22] Hooshmandi E,Ghasemi R,Iloun P,et al.The neuroprotective effect of agmatine against amyloid β-induced apoptosis in primary cultured hippocampal cells involving ERK,Akt/GSK-3β,and TNF-α[J].Mol Biol Rep,2019,46(1):489-496.DOI:10.1007/s11033-018-4501-4.
[23] Kang S,Kim CH,Jung H,et al.Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling[J].Neuropharmacology,2017,113(Pt A):467-479.DOI:10.1016/j.neuropharm.2016.10.029.
[24] Akasaka N,Fujiwara S.The therapeutic and nutraceutical potential of agmatine,and its enhanced production using Aspergillus oryzae[J].Amino Acids,2020,52(2):181-197.DOI:10.1007/s00726-019-02720-7.
[25] Chakraborty S,Lennon JC,Malkaram SA,et al.Serotonergic system,cognition,and BPSD in Alzheimer's disease[J].Neurosci Lett,2019,704:36-44.DOI:10.1016/j.neulet.2019.03.050.
[26] Jones LA,Sun EW,Martin AM,et al.The ever-changing roles of serotonin[J].Int J Biochem Cell Biol,2020,125:105776.DOI:10.1016/j.biocel.2020.105776.
[27] Ruiz-gonzalez C,Roman P,Rueda-Ruzafa L,et al.Effects of probiotics supplementation on dementia and cognitive impairment:A systematic review and meta-analysis of preclinical and clinical studies[J].Prog Neuropsychopharmacol Biol Psychiatry,2021,108:110189.DOI:10.1016/j.pnpbp.2020.110189.
[28] Liu Z,Dai X,Zhang H,et al.Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment[J].Nat Commun,2020,11(1):855.DOI:10.1038/s41467-020-14676-4.

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备注/Memo

备注/Memo:
通信作者:彭永德,Email:pengyongde0908@126.com
更新日期/Last Update: 2022-05-10