[1]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31-34.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
　Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(01):31-34.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
点击复制

肠道菌群与肥胖和糖尿病的关系()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年01
页码:
31-34
栏目:
肠道菌群与糖尿病专栏
出版日期:
2015-01-20

文章信息/Info

Title:
Relationship between gut microbiota, obesity and diabetes
作者:
刘艳清 易秋艳 邵加庆
10002南京，南方医科大学南京临床学院南京军区南京总医院内分泌科（刘艳清）；南京大学医学院临床学院南京军区南京总医院内分泌科（易秋艳）；南京军区南京总医院内分泌科（邵加庆）基金项目：国家自然科学基金资助项目(30900697,81471018)
Author(s):
Liu Yanqing; Yi Qiuyan; Shao Jiaqing.
Department of Endocrinology,Nanjing General Hospital of Military Command,Nanjing Clinical Institute of Southern Medical University, Nanjing 210002,ChinaCorresponding auther:Shao Jiaqing, Email:shaojiaq@hotmail.com
关键词:
肠道菌群; 2型糖尿病; 肥胖
Keywords:
Gut microbiota;  Type 2 diabetes mellitus;  Obesity
DOI:
DOI：10.3760/cma.j.issn.1673-4157.2015.01.007
摘要:
人的胃肠道内寄居着种类繁多的单细胞微生物，称为肠道菌群。基因、出生方式、婴幼儿喂养模式、抗生素应用、卫生居住条件以及长期的饮食习惯有助于塑造肠道菌群的组成。越来越多的动物和人体研究表明肠道菌群与肥胖和2型糖尿病密切相关。肠道菌群可通过宿主能量代谢、免疫系统及炎性反应等影响代谢综合征及2型糖尿病的发生、发展。干预肠道菌群有可能成为防治肥胖及糖尿病的新靶点。
Abstract:
A wide variety type of single celled organisms residing in our intestines, which called gut microbiome.Genetics,mode of birth,infant feeding patterns,antibiotic usage,sanitary living conditions and longterm dietary habits contribute to shaping the composition of the gut microbiome.Datas are accumulated in animal models and humans suggesting that obesity and type 2 diabetes are associated with gut microbiota.The gut microbiota could affect the development of metabolic syndrome and type 2 diabetes through energy metabolism, host immune system and inflammatory reaction. Intervention of gut microbiota may become a new target for prevention and treatment of obesity and diabetes.

参考文献/References:

[1]Devaraj S, Hemarajata P, Versalovic J. The human gut microbiome and body metabolism: implications for obesity and diabetes[J].Clin Chem,2013, 59(4): 617628.
[2]Voreades N, Kozil A,Weir TL.Diet and the development of the human intestinal microbiome[J].Front Microbiol,2014,5:494.?
[3]Flintoft L.Disease genomics: associations go metagenomewide[J]. Nat Rev Genet, 2012, 13(11): 756.
[4]Bckhed F, Ding H, Wang T, et al. The gyt microbiota as an environmental factor that regulates fat storage[J].Proc Natl Acad Sci U S A,2004,101(44): 15718-15723.
[5]Ley RE,Turnbaugh PJ,Klein S,et al.Microbial ecology:human gut microbes associated with obesity[J].Nature,2006, 444: 1022-1023.
[6]Le Chatelier E, Nielsen T, Qin J, et al. Richness of human gut microbiome correlates with metabolic markers[J].Nature, 2013,500(7464): 541-546.
[7]Ridaura VK, Faith JJ, Rey FE, et al. Gut microbiota from twins discordant for obesity modulate metabolism in mice[J].Science, 2013,341(6150):1241214.
[8]Duca FA, Sakar Y, Lepage P,et al. Replication of obesity and associated signaling pathways through transfer of microbiota from obese prone rats[J].Diabetes,2014,63(5):1624-1636.
[9]Qin J, Li Y, Cai Z, et al.A metagenome wide association study of gut microbiota in type 2 diabetes[J].Nature,2012，490(7418)：55-60.
[10]Zhang X, Shen D, Fang Z, et al. Human gut microbiota changes reveal the progression of glucose intolerance[J].PLoS One，2013，8(8):e71108.
[11]Giongo A, Gano KA, Crabb DB, et al. Toward defining the autoimmune microbiome for type 1 diabetes[J].ISME J, 2011,5(1):82-91.
[12]Murri M, Leiva I, Gomez Zumaquero JM, et al. Gut microbiota in children with type 1 diabetes differs from that in healthy children : a case control study[J]. BMC Med ,2013,11:46.
[13]Vrieze A, Van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome[J].Gastroenterology,2012, 143(4): 913-916.e7.
[14]Tilg H,Moschen AR.Microbiota and diabetes:an evolving relationship[J]. Gut,2014,63(9):1513-1521.
[15]Layden BT, Angueira AR, Brodsky M, et al. Short chain fatty acids and their receptors: new metabolic targets[J].Transl Res, 2013, 161(3): 131-140.
[16]Bckhed F, Manchester JK, Semenkovich CF, et al. Mechanisms underlying the resistance to dietinduced obesity in germfree mice[J].Proc Natl Acad Sci U S A，2007,104(3):979-984.
[17]Vijay-Kumar M,Aitken JD,Carvalho FA, et al. Metabolic syndrome ?and altered gut microbiota in mice lacking Toll-like receptor 5[J].Science,2010,328(5975):228-231.
[18]Stienstra R, Joosten LA, Koenen T, et al. The inflammasome mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity[J].Cell Metab, 2010,12(6):593-605.
[19]HenaoMejia J, Elinav E, Jin C, et al. Inflammasome mediated dysbiosis regulates progression of NAFLD and obesity[J].Nature,2012,482(7384):179-185.
[20]Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia ?initiates ?obesity and insulin resistance[J].Diabetes, 2007, 56(7): 1761-1772.?
[21]Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemiainduced inflammation in high fat dietinduced obesity and diabetes in mice[J].Diabetes, 2008, 57(6): 1470-1481.?
[22]Cani PD, Possemiers S, Van de Wiele T, et al. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2 driven improvement of gut permeability[J].Gut, 2009,58(8):1091-1103.
[23]Bolnick DI, Snowberg LK, Hirsch PE，et al. Individual diet has sexdependent effects on vertebrate gut microbiota[J].Nat ?Commun,2014,5:4500.?
[24]刘海霞，李晶，刘奔，等.阿卡波糖对2型糖尿病患者粪便中双歧杆菌数量的影响[J].中华内分泌代谢杂志，2011,27(11):928-931.
[25]张秀英，韩学尧，陈颖丽，等.阿卡波糖对糖尿病前期患者肠道菌群的影响∥中华医学会糖尿病学分会第十六次全国学术会议论文汇编，成都，2012[C].北京：《中华医学杂志》社有限责任公司，2012：119.
[26]Shin NR, Lee JC, Lee HY, et al.An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in dietinduced obese mice[J].Gut,2014,63(5):727-735.

相似文献/References:

[1]曾静波,王姮.2型糖尿病与自身免疫反应[J].国际内分泌代谢杂志,2007,(04):259.
[2]朱素君,谢锦桃,刘军,等.二甲双胍：2型糖尿病治疗的基础药[J].国际内分泌代谢杂志,2007,(04):280.
[3]赵丽娟,徐宽枫,杨涛,等.SLC30A8和PTPRD基因多态性与南京地区中老年人群2型糖尿病的相关性研究[J].国际内分泌代谢杂志,2015,(03):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
　Zhao Lijuan*,Xu Kuanfeng,Yang Tao,et al.Relationship between SLC30A8 and PTPRD gene polymorphisms and type 2 diabetes in middle aged and elderly people in Nanjing area[J].International Journal of Endocrinology and Metabolism,2015,(01):145.[doi:10.3760/cma.j.issn.1673-4157.2015.03.001]
[4]王洁,何媛,于珮.糖尿病肾病的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
　Wang Jie*,He Yuan,Yu Pei..Risk factors of diabetic nephropathy[J].International Journal of Endocrinology and Metabolism,2015,(01):153.[doi:10.3760/cma.j.issn.1673-4157.2015.03.003]
[5]刘帅,张萍,方毅,等.2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
　Liu Shuai*,Zhang Ping,Fang Yi,et al.Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(01):158.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
[6]徐庆海,马颖,李铁马.2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系[J].国际内分泌代谢杂志,2015,(04):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
　Xu Qinghai,Ma Ying,Li Tiema..Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(01):222.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
[7]潘道延,沈洁,朱筱,等.利格列汀对2型糖尿病大鼠代谢性内毒素血症的影响[J].国际内分泌代谢杂志,2015,(04):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
　Pan Daoyan,Shen Jie,Zhu Xiao,et al.Effects of linagliptin on metabolic endotoxemia in type 2 diabetic rats[J].International Journal of Endocrinology and Metabolism,2015,(01):230.[doi:10.3760/cma.j.issn.1673-4157.2015.04.004]
[8]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
　Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(01):265.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
[9]申翘璇,陈国芳,张丹毓,等.自然疗法治疗2型糖尿病的研究进展[J].国际内分泌代谢杂志,2015,(04):280.[doi:10.3760/cma.j.issn.1673-4157.2015.04.018]
　Shen Qiaoxuan,Chen Guofang,Zhang Danyu,et al.Update on naturopathic therapy for type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(01):280.[doi:10.3760/cma.j.issn.1673-4157.2015.04.018]
[10]琚丽萍,田景琰.低出生体重和2型糖尿病关系的遗传学研究进展[J].国际内分泌代谢杂志,2014,(01):63.[doi:10.3760/cma.j.issn.1673-4157.2014.01.018]
　Ju Liping,Tian Jingyan..Research progress on genetics of low birth weight and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2014,(01):63.[doi:10.3760/cma.j.issn.1673-4157.2014.01.018]
[11]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
　Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]

备注/Memo

备注/Memo:
(收稿日期：2014-10-20)
更新日期/Last Update: 2015-03-24