[1]黄桥,白洁,杜洪泉.一种新的脂肪细胞因子——cartonectin[J].国际内分泌代谢杂志,2015,(04):265-267.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
　Huang Qiao*,Bai Jie,Du Hongquan..A novel adipokine--cartonectin[J].International Journal of Endocrinology and Metabolism,2015,(04):265-267.[doi:10.3760/cma.j.issn.1673-4157.2015.04.014]
点击复制

一种新的脂肪细胞因子——cartonectin()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年04
页码:
265-267
栏目:
综述
出版日期:
2015-07-20

文章信息/Info

Title:
A novel adipokine--cartonectin
作者:
黄桥; 白洁; 杜洪泉
252000　聊城，泰山医学院聊城临床学院（黄桥）；252000　聊城市人民医院（白洁，杜洪泉）
Author(s):
Huang Qiao*; Bai Jie; Du Hongquan.
*Liaocheng Clinical School of Taishan Medical University，Liaocheng 252000，China Corresponding author：Bai Jie，Email：baijiebnm@163.com
关键词:
Cartonectin; 肥胖; 2型糖尿病; 炎症
Keywords:
Cartonectin; Obesity; Type 2 diabetes mellitus; Inflammation
DOI:
10.3760/cma.j.issn.1673-4157.2015.04.014
摘要:
Cartonectin与脂联素结构相似，但功能却不尽相同。研究发现，cartonectin通过抑制小鼠糖异生途径中的关键酶（葡萄糖6磷酸酶和磷酸烯醇式丙酮酸羧激酶），直接抑制肝糖输出；通过激活细胞外信号调节激酶1/2信号途径来调节转录因子Foxo1，从而间接抑制肝糖输出；还可通过抑制炎性反应、改善胰岛素信号转导来增加小鼠3T3-L1脂肪细胞胰岛素敏感性。另外，cartonectin还可促进新生血管形成保护心肌；促进血管平滑肌细胞增殖；促进软骨祖细胞增殖进而促进软骨形成及发育；还可增加睾酮含量。
Abstract:
Cartonectin and adiponectin are similar in structure but different in function. Cartonectin reduces directly glucose output in rat hepatocytes by suppressing the expression of glucose-6-phosphatase and phosphoenolpyruvate carboxykinase and reduces indirectly glucose output by activating the extracellular signal-regulated kinase1/2 signaling pathway which has been shown to regulate transcription factors Foxo1 in the liver of mouse. Cartonectin improves insulin sensitivity of 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction.On the other hand，cartonectin can protect heart by promoting angiogenesis and proliferation of vascular smooth muscle cell，promote cartilage progenitor cell proliferation and cartilage formation and development, increase testosterone levels.

参考文献/References:

[1]　Maeda T，Abe M，Kurisu K，et al.Molecular cloning and charac-terization of a novel gene，CORS26，encoding a putative secretory protein and its possible involvement in skeletal development[J].J Biol Chem，2001，276（5）：3628-3634. 　
[2]　Sch?覿ffler A，Weigert J，Neumeier M，et al.Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin"[J].Obesity （Silver Spring），2007，15（2）：303-313. 　
[3]　Maeda T，Jikko A，Abe M，et al.Cartducin，a paralog of Acrp30/adiponectin，is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondro-cytes[J].J Cell Physiol，2006，206（2）：537-544. 　
[4]　Sch?覿ffler A，Ehling A，Neumann E，et al.Role of specificity protein-1，PPARgamma，and pituitary protein transcription factor-1 in transcriptional regulation of the murine CORS-26 promoter[J].Biochim Biophys Acta，2004，1678（2-3）：150-156. 　
[5]　Svestak M，Sporova L，Hejduk P，et al.Collagenous repeat-containing sequence of 26 kDa protein-a newly discovered adipokine-sensu lato-A minireview[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub，2010，154（3）：199-202. 　
[6]　Takahashi M，Arita Y，Yamagata K，et al.Genomic structure and mutations in adipose-specific gene，adiponectin[J].Int J Obes Relat Metab Disord ，2000，24（7）：861-868. 　
[7]　Peterson JM，Wei Z，Wong GW.C1q/TNF-related protein-3 （CTRP3），a novel adipokine that regulates hepatic glucose output[J].J Biol Chem，2010，285（51）：39691-39701. 　
[8]　Sch?覿ffler A，Ehling A，Neumann E，et al.Genomic organization， chromosomal localization and adipocytic expression of the murine gene for CORS-26 （collagenous repeat-containing sequence of 26 kDa protein） [J].Biochim Biophys Acta，2003， 1628（1）：64-70. 　
[9]　Choi KM，Hwang SY，Hong HC，et al.C1q/TNF-related protein-3 （CTRP-3） and pigment epithelium-derived factor （PEDF） concentrations in patients with type 2 diabetes and metabolic syndrome[J].Diabetes，2012，61（11）：2932-2936.
[10]　Tan BK，Chen J，Hu J，et al.Metformin increases the novel adipokine cartonectin/CTRP3 in women with polycystic ovary syndrome[J].J Clin Endocrinol Metab.2013，98（12）：E1891-E1900.
[11]　Li X，Jiang L，Yang M，et al.Expression of CTRP3，a novel adipokine，in rats at different pathogenic stages of type 2 diabetes mellitus and the impacts of GLP-1 receptor agonist on it[J].J Diabetes Res，2014，2014：398518.
[12]　Li X，Jiang L，Yang M，et al.CTRP3 improves the insulin sensi-tivity of 3T3-L1 adipocytes by inhibiting inflammation and ameliorating insulin signalling transduction[J].Endokrynol Pol，2014，65（4）：252-258.
[13]　Li X，Jiang L，Yang M，et al.CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes[J].Endocr J，2014，61（12）：1153-1162.
[14]　W?觟lfing B，Buechler C，Weigert J，et al.Effects of the new C1q/TNF-related protein （CTRP-3） "cartonectin" on the adipocytic secretion of adipokines[J].Obesity（Silver Spring），2008，16（7）：1481-1486.
[15]　Yoo HJ，Hwang SY，Hong HC，et al.Implication of progranulin and C1q/TNF-related protein-3（CTRP3） on inflammation and atherosclerosis in subjects with or without metabolic syndrome[J].PLoS One，2013，8（2）：e55744.
[16]　Choi HY，Park JW，Lee N，et al.Effects of a combined aerobic and resistance exercise program on C1q/TNF-related protein-3 （CTRP-3） and CTRP-5 levels[J].Diabetes Care，2013，36（10）：3321-3327.
[17]　Yi W，Sun Y，Yuan Y，et al.C1q/tumor necrosis factor-related protein-3，a newly identified adipokine，is a novel antiapoptotic，proangiogenic，and cardioprotective molecule in the ischemic mouse heart[J].Circulation，2012，125（25）：3159-3169.
[18]　Akiyama H，Furukawa S，Wakisaka S，et al.Cartducin stimulates mesenchymal chondroprogenitor cell proliferation through both extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways[J].FEBS J，2006，273（10）：2257-2263.
[19]　Maeda T，Wakisaka S.CTRP3/cartducin is induced by trans-forming growth factor-beta1 and promotes vascular smooth muscle cell proliferation[J].Cell Biol Int，2010，34（3）：261-266.
[20]　Yokohama-Tamaki T，Maeda T，Tanaka TS，et al.Functional analysis of CTRP3/cartducin in Meckel's cartilage and developing condylar cartilage in the fetal mouse mandible[J].J Anat，2011， 218（5）：517-533.
[21]　Otani M，Kogo M，Furukawa S，et al.The adiponectin paralog C1q/TNF-related protein 3（CTRP3） stimulates testosterone pro-duction through the cAMP/PKA signaling pathway[J].Cytokine，2012，58（2）：238-244.

相似文献/References:

[1]刘艳清 易秋艳 邵加庆.肠道菌群与肥胖和糖尿病的关系[J].国际内分泌代谢杂志,2015,(01):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
　Liu Yanqing,Yi Qiuyan,Shao Jiaqing..Relationship between gut microbiota, obesity and diabetes[J].International Journal of Endocrinology and Metabolism,2015,(04):31.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.007]
[2]姚旻 赵爱源 张宏.肠道菌群与2型糖尿病[J].国际内分泌代谢杂志,2015,(01):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
　Yao Min*,Zhao Aiyuan,Zhang Hong..Relationship between gut microbiota and type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(04):35.[doi:DOI：10.3760/cma.j.issn.1673-4157.2015.01.008]
[3]胡明玥 沈山梅.棕色脂肪检测技术的研究进展[J].国际内分泌代谢杂志,2015,(01):41.[doi:10.3760/cma.j.issn.1673-4157.2015.01.010]
　Hu Mingyue*,Shen Shanmei..Assessments of brown adipose tissue Hu Mingyue*,Shen Shanmei.*Medical College of Southeast University,Nanjing 210009,China[J].International Journal of Endocrinology and Metabolism,2015,(04):41.[doi:10.3760/cma.j.issn.1673-4157.2015.01.010]
[4]郑仁东,曹琳,刘克冕,等.超重或肥胖的男性2型糖尿病患者 性激素水平的研究[J].国际内分泌代谢杂志,2015,(02):84.[doi:10.3760/cma.j.issn.1673-4157.2015.02.004]
　Zheng Rendong,Cao Lin,Liu Kemian,et al.Study on sex hormone levels in overweight or obese type 2 diabetic male patients[J].International Journal of Endocrinology and Metabolism,2015,(04):84.[doi:10.3760/cma.j.issn.1673-4157.2015.02.004]
[5]王滢,李倩.脑利钠肽与糖脂代谢的关系[J].国际内分泌代谢杂志,2015,(02):103.[doi:10.3760/cma.j.issn.1673-4157.2015.02.008]
　Wang Ying,Li Qian..Association between brain natriuretic peptide and glycolipid metabolism[J].International Journal of Endocrinology and Metabolism,2015,(04):103.[doi:10.3760/cma.j.issn.1673-4157.2015.02.008]
[6]王兴纯,程晓芸,曲伸.代餐饮食对代谢紊乱改善的作用及其机制[J].国际内分泌代谢杂志,2015,(02):106.[doi:10.3760/cma.j.issn.1673-4157.2015.02.009]
　Wang Xingchun,Cheng Xiaoyun,Qu Shen..Roles of meal replacement in the improvement of metabolic disorders and related mechanism[J].International Journal of Endocrinology and Metabolism,2015,(04):106.[doi:10.3760/cma.j.issn.1673-4157.2015.02.009]
[7]贺肴,张弛,刘瑛,等.代谢正常肥胖合并非酒精性脂肪性肝病的临床特征及内皮功能研究[J].国际内分泌代谢杂志,2015,(03):163.[doi:10.3760/cma.j.issn.1673-4157.2015.03.005]
　He Yao,Zhang Chi,Liu Ying,et al.Clinical features and endothelial function in metabolically healthy obese patients with nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2015,(04):163.[doi:10.3760/cma.j.issn.1673-4157.2015.03.005]
[8]黄莉吉,谢绍锋,刘超.肥胖相关性肾病的研究进展[J].国际内分泌代谢杂志,2015,(03):180.[doi:10.3760/cma.j.issn.1673-4157.2015.03.010]
　Huang Liji*,Xie Shaofeng,Liu Chao..Obesity-related glomerulopathy[J].International Journal of Endocrinology and Metabolism,2015,(04):180.[doi:10.3760/cma.j.issn.1673-4157.2015.03.010]
[9]刘美娟,朱惠娟,龚凤英.Glypican-，4与肥胖及胰岛素抵抗[J].国际内分泌代谢杂志,2015,(03):183.[doi:10.3760/cma.j.issn.1673-4157.2015.03.011]
　Liu Meijuan,Zhu Huijuan,Gong Fengying..Glypican-4 and obesity，insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(04):183.[doi:10.3760/cma.j.issn.1673-4157.2015.03.011]
[10]刘琳,高鑫.肥胖与心脏结构及功能的改变[J].国际内分泌代谢杂志,2015,(03):187.[doi:10.3760/cma.j.issn.1673-4157.2015.03.012]
　Liu Lin,Gao Xin..Relationship between obesity and changes of cardiac structure and function[J].International Journal of Endocrinology and Metabolism,2015,(04):187.[doi:10.3760/cma.j.issn.1673-4157.2015.03.012]

备注/Memo

备注/Memo:
通信作者：白洁，Email：baijiebnm@163.com
更新日期/Last Update: 2015-07-20