[1]贺肴,张弛,刘瑛,等.代谢正常肥胖合并非酒精性脂肪性肝病的临床特征及内皮功能研究[J].国际内分泌代谢杂志,2015,(03):163-165,169.[doi:10.3760/cma.j.issn.1673-4157.2015.03.005]
　He Yao,Zhang Chi,Liu Ying,et al.Clinical features and endothelial function in metabolically healthy obese patients with nonalcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2015,(03):163-165,169.[doi:10.3760/cma.j.issn.1673-4157.2015.03.005]
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代谢正常肥胖合并非酒精性脂肪性肝病的临床特征及内皮功能研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
163-165,169
栏目:
论著
出版日期:
2015-05-20

文章信息/Info

Title:
Clinical features and endothelial function in metabolically healthy obese patients with nonalcoholic fatty liver disease
作者:
贺肴; 张弛; 刘瑛; 谢环; 张沥; 李华珠; 杨晓春; 周桂莲; 王敏; 熊璞
410005　长沙，湖南师范大学第一附属医院，湖南省人民医院内分泌科
Author(s):
He Yao; Zhang Chi; Liu Ying; Xie Huan; Zhang Li; Li Huazhu; Yang Xiaochun; Zhou Guilian; Wang Min; Xiong Pu.
Department of Endocrinology，The People's Hospital of Hunan Province， The First Affiliated Hospital of Hunan Normal University，Changsha 410005，China
关键词:
肥胖; 代谢正常肥胖; 非酒精性脂肪性肝病
Keywords:
Obesity; Metabolically healthy obesity; Nonalcoholic fatty liver disease
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.005
摘要:
目的　探讨代谢正常肥胖（MHO）合并非酒精性脂肪性肝病（NAFLD）患者的临床、生化特征及内皮功能。方法　收集湖南省人民医院体检中心2006年4月—2014年1月体检人群的资料，排除资料不完整者，共5 147名。选择诊断为MHO患者（共478例）纳入研究，其中234例合并NAFLD（MHO合并NAFLD组），244例未合并NAFLD（MHO未合并NAFLD组）。共获得56例MHO（29例为MHO合并NAFLD，27例为MHO未合并NAFLD）患者的血标本，检测C反应蛋白（CRP）、血清空腹胰岛素（FINS）、脂联素、内皮素-1，计算稳态模型评估-胰岛素抵抗指数（HOMA-IR），记录受检者身高、体重、收缩压、舒张压、甘油三酯、总胆固醇、低密度脂蛋白-胆固醇（LDL-C）、高密度脂蛋白-胆固醇（HDL-C）、空腹血糖、谷丙转氨酶（ALT）、尿酸、外周血白细胞计数（WBCC）及腹部B超结果。比较MHO合并NAFLD组与MHO未合并NAFLD组临床、生化特征、炎性因子及内皮素-1水平的差异。结果　MHO合并NFALD组与MHO未合并NAFLD组相比，年龄（t =-4.164）、体重指数（t =-4.519）、收缩压（t =-3.892）、空腹血糖水平（t =-2.549）、ALT（t =-2.019）、HOMA-IR（u=-2.091）、内皮素-1水平（u=-3.632）升高，脂联素水平（u=-2.206）降低（P均＜0.05）。而性别、舒张压、甘油三酯、总胆固醇、LDL-C、HDL-C、尿酸、WBCC、FINS、CRP在两组间差别无统计学意义。结论　MHO合并NAFLD患者者代谢异常加重，内皮功能紊乱。
Abstract:
Objective　To investigate the clinical parameters，biochemical parameters and endothelial function in metabolically healthy obese（MHO） patients with nonalcoholic fatty liver disease（NAFLD）.Methods　Data from 5 147 subjects undergone physical examination from April 2006 to January 2014 were collected in People's Hospital of Hunan Province. Among which 478 were diagnosed with MHO，and were included in this study. They were divided into two groups according to NAFLD status：MHO with NAFLD group （n =234），MHO without NAFLD group（n =244）. In addition，blood samples from 56 subjects （29 MHO with NAFLD，27 MHO without NAFLD） were preserved to detect C-reactive protein（CRP），fasting insulin（FINS）， adiponectin and endothelin-1 level. Homeostasis model assessment -insulin resistance index （HOMA-IR） was calculated. Body height，body weight，systolic blood pressure，diastolic blood pressure，triglyceride，total cholesterol，low density lipoprotein cholesterol（LDL-C），high density lipopro-tein cholesterol（HDL-C），fast blood glucose，alanine aminotransferase （ALT），uric acid，peripheral white blood cell count（WBCC） and abdominal B ultrasound were recorded. Clinical parameters，metabolic parameters，the level of inflammatory cytokines and endothelin-1 were compared between MHO with NAFLD group and MHO without NAFLD group. Results　Compared with MHO without NAFLD group，age（t =-4.164），body mass index（t =-4.519），systolic blood pressure（t =-3.892），fast blood glucose（t =-2.549），ALT（t =-2.019），HOMA-IR（u=-2.091），endothelin-1（u=-3.632） were higher than those in MHO with NAFLD group，and adiponectin was lower than that in MHO with NAFLD group（u=-2.206，all P ＜0.05）. There was no difference in sex，diastolic blood pressure，triglyceride，total cholesterol，LDL-C，HDL-C，uric acid，peripheral WBCC，FINS，CRP between the two groups. Conclusions　Patients with MHO and NAFLD have aggravated metabolic abnormalities and endothelial dysfunction.

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备注/Memo

备注/Memo:
基金项目：湖南省科技计划基金资助项目（2011SK3160）；湖南省保健委重点基金项目（A2009-02）；湖南省卫生厅重点基金资助项目（A2007005）
更新日期/Last Update: 2015-05-20