[1]刘帅,张萍,方毅,等.2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析[J].国际内分泌代谢杂志,2015,(03):158-162.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
　Liu Shuai*,Zhang Ping,Fang Yi,et al.Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients[J].International Journal of Endocrinology and Metabolism,2015,(03):158-162.[doi:10.3760/cma.j.issn.1673-4157.2015.03.004]
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2型糖尿病合并无症状冠状动脉钙化的相关危险因素分析()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
158-162
栏目:
论著
出版日期:
2015-05-20

文章信息/Info

Title:
Analysis of the risk factors related with asymptomatic coronary calcification for type 2 diabetic patients
作者:
刘帅; 张萍; 方毅; 刘然; 郑丹; 乔阳
100071　北京，中国人民解放军307医院内分泌科（刘帅，方毅，刘然，郑丹，乔阳）；116023　大连医科大学附属二院内分泌科（刘帅，张萍）
Author(s):
Liu Shuai*; Zhang Ping; Fang Yi; Liu Ran; Zheng Dan; Qiao Yang.
*Department of Endocrinology，307 Hospital of PLA，Beijing 100071，China Corresponding author：Zhang Ping，Email：zping717@medmail.com.cn
关键词:
2型糖尿病; 冠心病; 钙化积分; 危险因素
Keywords:
Type 2 diabetes mellitus; Coronary heart disease; Calcification score; Risk factors
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.004
摘要:
目的　分析2 型糖尿病合并无症状冠状动脉钙化的危险因素。方法　选取2013年6月至2014年3月在大连医科大学附属二院住院治疗的2型糖尿病患者共199例作为研究对象。（1）根据患者有无胸闷、气短及与冠心病相关的异位疼痛等症状分为有症状组（89例）和无症状组（110例），颈部血管超声结果确定无症状组均有动脉硬化，两组均行冠状动脉CT检查。（2）根据冠状动脉钙化积分将有症状组与无症状组再分为钙化积分＞10分与钙化积分＜10分两个亚组。结果　 （1）与有症状钙化积分＞10分组相比，无症状钙化积分＞10分组的体重指数、尿酸水平降低，尿微量白蛋白与尿肌酐比值（UACR）、高血压发生率、神经病变发生率较高（t =-1.990，-2.440，2.923，X2=4.459，10.941，P均＜0.05）。（2）无症状钙化积分＜10分组平均糖尿病病程、年龄、UACR、高血压发生率、视网膜病变发生率、下肢动脉粥样硬化发生率明显小于无症状钙化积分＞10分组（t =-3.700，-3.440，-5.170，X2=4.880，6.761，4.951，P均＜0.05）。（3）高龄、糖尿病病程长、UACR高的2型糖尿病患者发生无症状冠状动脉钙化的优势比（OR）值（95%CI）分别为1.059（1.010~1.112），1.110（1.021~1.207），1.009（1.000~1.019）。结论　年龄、糖尿病病程、UACR是2型糖尿病合并无症状冠状动脉钙化异常的独立危险因素。
Abstract:
Objective　To analyze the risk factors of asymptomatic coronary artery calcification in type 2 diabetic patients. Methods　One hundred and ninety-nine in-hospital patients with type 2 diabetes were included in the Second Affiliated Hospital of Dalian Medical University from June 2013 to March 2014. （1）All patients were divided into symptomatic group （n=89） and asymptomatic group （n=110） according to chest tightness，shortness of breath and ectopic pain and other symptoms associated with coronary heart disease. Arteriosclerosis in neck veins was proved in patients of asymptomatic group by carotid ultrasonography. Patients in both groups were performed coronary artery CT examination.（2） All patients were divided into two subgroups according to coronary artery calcification score：calcification score＞10 points group and calcification score＜10 points group. Results　（1） Compared with symptoms and calcification score＞10 group，body mass index，uric acid were lower，while urine microalbumin/urine creatinine ratio（UACR），hypertension and neuropathy incidence rate were higher in asymptomatic and calcification score＞10 group（t =-1.990，-2.440，2.923，X2=4.459，10.941，all P ＜0.05）.（2） Compared with asymptomatic and calcification score＞10 group，course of disease，age，UACR，incidence of hypertension，retinopathy，lower limb atherosclerosis were obviously lower in asymptomatic and calcification score＞10 group（t =-3.700，-3.440，-5.170，X2=4.880，6.761， 4.951，all P ＜0.05）. （3） The odd ratio （OR） value （95% CI） for asymptomatic patients with older age，longer diabetes duration and higher UACR was 1.059（1.010-1.112），1.110（1.021-1.207） and 1.009（1.000-1.019），respectively. Conclusion　Age，diabetes duration and UACR are the independent risk factors for coronary artery calcification in type 2 diabetic patients.

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备注/Memo

备注/Memo:
通信作者：张萍，Email：zping717@medmail.com.cn
更新日期/Last Update: 2015-05-20