[1]徐庆海,马颖,李铁马.2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系[J].国际内分泌代谢杂志,2015,(04):222-225.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
　Xu Qinghai,Ma Ying,Li Tiema..Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(04):222-225.[doi:10.3760/cma.j.issn.1673-4157.2015.04.002]
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2型糖尿病患者高甘油三酯血症-腰围表型与甲状腺功能异常的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年04
页码:
222-225
栏目:
论著
出版日期:
2015-07-20

文章信息/Info

Title:
Association of hypertriglyceridaemic-waist phenotype with thyroid dysfunction in patients with type 2 diabetes mellitus
作者:
徐庆海; 马颖; 李铁马
300480　天津滨海新区汉沽中医院内科
Author(s):
Xu Qinghai; Ma Ying; Li Tiema.
Department of Internal Medicine，Hangu Chinese Medicine Hospital，Binhai New Area，Tianjin 300480，China
关键词:
2型糖尿病; 高甘油三酯血症-腰围表型; 甲状腺功能
Keywords:
Type 2 diabetes mellitus; Hypertriglyceridaemic-waist phenotype; Thyroid function
DOI:
10.3760/cma.j.issn.1673-4157.2015.04.002
摘要:
目的　探讨2型糖尿病患者高甘油三酯血症-腰围表型（HTWC）与甲状腺功能的关系。方法　选取2型糖尿病患者808例，以血甘油三酯≥1.7 mmol/L、腰围男性≥85 cm或女性≥80 cm为切点，分为4组：正常组（n=162）、单纯高甘油三酯组（n=112）、单纯腹型肥胖组（n=262）、HTWC组（n=272）。测量所有患者身高、体重、腰围、血压；检测血糖、血脂、促甲状腺激素、游离T3、游离T4、甲状腺过氧化物酶抗体水平，计算体重指数以及稳态模型评估-胰岛素抵抗指数（HOMA-IR）。结果　HTWC组体重指数、收缩压、腰围、HOMA-IR、促甲状腺激素、甲状腺过氧化物酶抗体均高于其他3组（F =5.537~53.038，P均＜0.05），而高密度脂蛋白-胆固醇、游离T4显著低于其他3组（F =8.561，4.399，P均＜0.05），且HTWC组亚临床甲状腺功能减退症和甲状腺抗体阳性发生率较其余3组明显升高（?字2=4.348，4.774，P均＜0.05）。Logistic回归分析显示HTWC是2型糖尿病发生亚临床甲状腺功能减退症的危险因素（优势比=1.461，95%CI：1.073～1.990，P =0.016）。结论　在2型糖尿病患者中，HTWC与甲状腺功能异常存在相关性，并可增加亚临床甲状腺功能减退症的患病风险。
Abstract:
Objective　To investigate the association of hypertriglyceridaemic-waist（HTWC） phenotype with thyroid function in patients with type 2 diabetes mellitus. Methods　Based on the cutoff point of plasma triglycerides concentration （≥1.7 mmol/L） and waist circumference （≥85 cm in men or ≥80 cm in women），808 patients with type 2 diabetes mellitus were divided into four groups：normal group（n=162）， hypertriglyceridemia group （n=112），abdominal obesity group（n=262） and HTWC group（n=272）. Height， weight， waist circumference，blood pressure were measured. Levels of blood glucose，blood lipids，thyroid stimulating hormone，free T3，free T4 and thyroid peroxidase antibody were detected. Body mass index（BMI），homeostasis model assessment-insulin resistance（HOMA-IR） were calculated. Results　BMI，systolic blood pressure，waist circumference，HOMA-IR，thyroid stimulating hormone and thyroid peroxidase antibody in HTWC group were significantly higher than those in other three groups （F =5.537-53.038，all P ＜0.05），while high density lipoprotein-cholesterol and free T4 were lower than those in other three groups（F = 8.561，4.399，all P＜0.05）. Compared with other three groups，the incidence of subclinical hypothyroidism and positive thyroid autoantibody were significant increased in HTWC group （?字2=4.348， 4.774， all P＜0.05）. Logistic regression analysis revealed that HTWC was a risk factor of subclinical hypothyroidism in type 2 diabetes mellitus（odd ratio=1.461，95%CI:1.073-1.990，P =0.016）. Conclusion　HTWC associates with thyroid dysfunction，and may increase the risk of subclinical hypothyroidism in type 2 diabetes mellitus.

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更新日期/Last Update: 2015-07-20