[1]杨雪 韦晓 杨婉薇 陈国芳 刘超.代谢组学在糖尿病研究中的应用[J].国际内分泌代谢杂志,2018,38(05):343-346.[doi:10.3760/cma.j.issn.1673-4157.2018.05.015]
 Yang Xue,Wei Xiao,Yang Wanwei,et al.Application of metabonomics in diabetic research[J].International Journal of Endocrinology and Metabolism,2018,38(05):343-346.[doi:10.3760/cma.j.issn.1673-4157.2018.05.015]
点击复制

代谢组学在糖尿病研究中的应用()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年05期
页码:
343-346
栏目:
基础研究
出版日期:
2018-09-20

文章信息/Info

Title:
Application of metabonomics in diabetic research
作者:
杨雪 韦晓 杨婉薇 陈国芳 刘超
作者单位:210028 南京中医药大学附属中西医结合医院内分泌代谢病院区,江苏省中医药研究院
Author(s):
Yang Xue Wei Xiao Yang Wanwei Chen Guofang Liu Chao
Department of Endocrinology and Metabolism, Affiliated Hospital of Traditional Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medical Science, Nanjing 210028, China
关键词:
代谢组学 糖尿病 代谢性疾病
Keywords:
Metabolomics Diabetes mellitus Metabolic diseases
DOI:
10.3760/cma.j.issn.1673-4157.2018.05.015
摘要:
糖尿病是以糖、脂代谢紊乱为主要表现的代谢性疾病,其并发症导致致死率和致残率极高。目前糖尿病确切的发病机制仍未可知,也未见有效的根治方法。代谢组学作为一种能够识别和测量生物体代谢变化的新技术,可以揭示机体生命活动的代谢本质,其在糖尿病疾病预测、疾病诊断、发病机制和药物疗效评价方面发挥重大作用,其主要的检测手段包括核磁共振与质谱技术。
Abstract:
Diabetes mellitus is a metabolic disease which mainly characterized by glucose and lipid metabolism disorders, and its complications lead to extremely high mortality and disability. The exact pathogenesis of diabetes is still unknown, and there is no effective cure. As a new technology, metabonomics can identify and measure metabolic changes in organisms, reveal the metabolic nature of organisms, vital movement. It plays a major role in the prediction, diagnosis, pathogenesis and drug efficacy of diabetes mellitus. Detection methods of metabolomics include nuclear magnetic resonance and mass spectrometry techniques.

参考文献/References:


[1] Turner N, Zeng XY, Osborne B,et al. Repurposing drugs to target the diabetes epidemic[J].Trends Pharmacol Sci,2016,37(5):379-389. DOI:10.1016/j.tips.2016.01.007.
[2] Chowdhury MK,Turner N,Bentley NL,et al.Niclosamide reduces giucagon sensitivity via hepatic PKA inhibition in obese mice: implications for glucose metabolism improvements in type 2 diabetes[J].Sci Rep,2017,7:40159. DOI:10.1038/srep40159.
[3] Tzoulaki I,Ebbels TM,Valdes A,et al.Design and analysis of metabolomics studies in epidemiologic research:a primer on -omic technologies[J].Am J Epidemiol,2014,180(2):129-139.DOI:10.1093/aje/kwu143.
[4] Nicholson JK,Holmes E,Kinross JM,et al. Metabolic phenotyping in clinical and surgical environments[J].Nature,2012,491(7424):384-392.DOI:10.1038/nature11708.
[5] Verma M,Khoury MJ,Ioannidis JP.Opportunities and challenges for selected emerging technologies in cancer epidemiology: mitochondrial, epigenomic, metabolomic, and telomerase profiling[J].Cancer Epidemiol Biomarkers Prev,2013,22(2):189-200.DOI:10.1158/1055-9965.EPI-12-1263.
[6] Emwas AH.The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research[J].Methods Mol Biol,2015,1277:161-193. DOI:10.1007/978-1-4939-2377-9_13.
[7] Pourmodheji H, Ghafar-Zadeh E, Magierowski S. A multidisciplinary approach to high throughput nuclear magnetic resonance spectroscopy[J].Sensors(Basel),2016,16(6):pii: E850.DOI:10.3390/s16060850.
[8] Patti GJ,Yanes O,Siuzdak G.Innovation: metabolomics: the apogee of the omics trilogy[J].Nat Rev Mol Cell Biol,2012,13(4):263-269. DOI:10.1038/nrm3314.
[9] Mook-Kanamori DO,Selim MM,Takiddin AH,et al.1,5-Anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control[J].J Clin Endocrinol Metab,2014,99(3):E479-E483.DOI:10.1210/jc.2013-3596.
[10] Perry RJ,Peng L,Barry NA,et al.Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome[J].Nature,2016,534(7606):213-217. DOI:10.1038/nature18309.
[11] Li L,Wang C,Yang H,et al.Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients[J].Mol Biosyst,2017,13(11):2392-2400. DOI:10.1039/c7mb00167c.
[12] Zhao L,Ni Y,Ma X,et al.A panel of free fatty acid ratios to predict the development of metabolic abnormalities in healthy obese individuals[J].Sci Rep,2016,6:28418.DOI:10.1038/srep28418.
[13] Mack LR, Tomich PG. Gestational diabetes: diagnosis, classification, and clinical care[J]. Obstet Gynecol Clin North Am, 2017,44(2):207-217.DOI:10.1016/j.ogc.2017.02.002.
[14] Law KP, Zhang H. The pathogenesis and pathophysiology of gestational diabetes mellitus: deductions from a three-part longitudinal metabolomics study in China[J].Clin Chim Acta,2017,468:60-70. DOI:10.1016/j.cca.2017.02.008.
[15] Zheng H,Lin Q,Wang D,et al.NMR-based metabolomics reveals brain region-specific metabolic alterations in streptozotocin-induced diabetic rats with cognitive dysfunction[J].Metab Brain Dis,2017,32(2):585-593. DOI:10.1007/s11011-016-9949-0.
[16] Sun T,Rong Y,Hu X,et al.Plasma alkylresorcinol metabolite, a biomarker of whole-grain wheat and rye intake, and risk of type 2 diabetes and impaired glucose regulation in a Chinese population[J].Diabetes Care,2018,41(3):440-445.DOI:10.2337/dc17-1570.
[17] Tanaka S,Tanaka S,Iimuro S,et al.Cohort profile: the Japan diabetes complications study: a long-term follow-up of a randomised lifestyle intervention study of type 2 diabetes[J].Int J Epidemiol,2014,43(4):1054-1062.DOI:10.1093/ije/dyt057.
[18] Zhao J, Zhu Y, Hyun N,et al. Novel metabolic markers for the risk of diabetes development in American Indians[J].Diabetes Care,2015,38(2):220-227. DOI:10.2337/dc14-2033.
[19] Floegel A,Stefan N,Yu Z,et al.Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach[J].Diabetes,2013,62(2):639-648.DOI:10.2337/db12-0495.
[20] Ni Y,Zhao L,Yu H,et al.Circulating unsaturated fatty acids delineate the metabolic status of obese individuals[J].EBioMedicine,2015,2(10):1513-1522.DOI:10.1016/j.ebiom.2015.09.004.
[21] Chen T, Ni Y, Ma X, et al. Branched-chain and aromatic amino acid profiles and diabetes risk in chinese populations[J]. Sci Rep, 2016, 6:20594. DOI: 10.1038/srep20594.
[22] Chen T,Zheng X,Ma X,et al.Tryptophan predicts the risk for future type 2 diabetes[J].PLoS One,2016,11(9):e0162192.DOI:10.1371/journal.pone.0162192.
[23] Cobb J,Eckhart A,Motsinger-Reif A,et al.α-hydroxybutyric acid is a selective metabolite biomarker of impaired glucose tolerance[J].Diabetes Care,2016,39(6):988-995.DOI:10.2337/dc15-2752.
[24] Pena MJ,de Zeeuw D,Andress D,et al.The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathy[J].Diabetes Obes Metab,2017,19(5):749-753.DOI:10.1111/dom.12864.
[25] Tao Y,Chen X,Cai H,et al.Untargeted serum metabolomics reveals Fu-Zhu-Jiang-Tang tablet and its optimal combination improve an impaired glucose and lipid metabolism in type Ⅱ diabetic rats[J].J Chromatogr B Analyt Technol Biomed Life Sci,2017,1040:222-232.DOI:10.1016/j.jchromb.2016.11.012.
[26] Xu T,Brandmaier S,Messias AC,et al. Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes[J].Diabetes Care,2015,38(10):1858-1867.DOI:10.2337/dc15-0658.
[27] Zhao T,Zhang H,Zhang X,et al.Metabolomic and lipidomic study of the protective effect of Chaihuang-Yishen formula on rats with diabetic nephropathy[J].J Ethnopharmacol,2015,166:31-41.DOI:10.1016/j.jep.2015.02.019.

相似文献/References:

[1]李春睿,王静,陈峰,等.GLP-1受体激动剂对糖尿病患者肾功能的影响[J].国际内分泌代谢杂志,2014,(06):401.[doi:10.3760/cma.j.issn.1673-4157.2014.06.011]
 Li Chunrui*,Wang Jing,Chen Feng,et al.Effects of GLP-1 receptor agonists on renal function of diabetics[J].International Journal of Endocrinology and Metabolism,2014,(05):401.[doi:10.3760/cma.j.issn.1673-4157.2014.06.011]
[2]黄珊珊,鲁一兵.长链非编码RNA与糖尿病[J].国际内分泌代谢杂志,2015,(04):271.[doi:10.3760/cma.j.issn.1673-4157.2015.04.016]
 Huang Shanshan*,Lu Yibing..Long non-coding RNA and diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(05):271.[doi:10.3760/cma.j.issn.1673-4157.2015.04.016]
[3]高瑞霄,姚朱华,冯凭,等.尿8-羟基脱氧鸟苷在2型糖尿病及糖尿病合并冠心病患者中的临床意义[J].国际内分泌代谢杂志,2014,(05):295.[doi:10.3760/cma.j.issn.1673-4157.2014.05.002]
 Gao Ruixiao*,Yao Zhuhua,Feng Ping,et al.The clinical significance of urinary 8-hydroxy deoxyguanosine in patients with type 2 diabetes mellitus and diabetic patients with coronary heart disease[J].International Journal of Endocrinology and Metabolism,2014,(05):295.[doi:10.3760/cma.j.issn.1673-4157.2014.05.002]
[4]郑佳,肖新华.葡萄糖稳态的中枢调控作用机制 ——2014年美国糖尿病协会“杰出科学成就奖” 演讲报告解读[J].国际内分泌代谢杂志,2014,(05):305.[doi:10.3760/cma.j.issn.1673-4157.2014.05.004]
 Zheng Jia,Xiao Xinhua.The mechanisms of central nervous system in the control of glucose homeostasis--A summary of 2014 ADA "Outstanding Scientific Achievement Award" Lecture[J].International Journal of Endocrinology and Metabolism,2014,(05):305.[doi:10.3760/cma.j.issn.1673-4157.2014.05.004]
[5]唐勤,邵莉.蛋白乙酰化与胰岛素分泌[J].国际内分泌代谢杂志,2014,(05):313.[doi:10.3760/cma.j.issn.1673-4157.2014.05.007]
 Tang Qin,Shao Li..Protein acetylation and insulin secretion[J].International Journal of Endocrinology and Metabolism,2014,(05):313.[doi:10.3760/cma.j.issn.1673-4157.2014.05.007]
[6]卢婷婷,任思佳,沈捷.人群迁徙对糖尿病患病率的影响及其相关因素[J].国际内分泌代谢杂志,2014,(05):327.[doi:10.3760/cma.j.issn.1673-4157.2014.05.011]
 Lu Tingting,Ren Sijia,Shen Jie..Impact of migration on prevalence of diabetes and risk factors[J].International Journal of Endocrinology and Metabolism,2014,(05):327.[doi:10.3760/cma.j.issn.1673-4157.2014.05.011]
[7]包薇萍,陈国芳,刘超.DPP-4抑制剂的肾保护作用[J].国际内分泌代谢杂志,2014,(05):337.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
 Bao Weiping,Chen Guofang,Liu Chao..Renal protective effects of dipeptidyl peptidase-4 inhibitors[J].International Journal of Endocrinology and Metabolism,2014,(05):337.[doi:10.3760/cma.j.issn.1673-4157.2014.05.014]
[8]孟庆冬,陶红.巨噬细胞凋亡与糖尿病动脉粥样硬化[J].国际内分泌代谢杂志,2014,(05):340.[doi:10.3760/cma.j.issn.1673-4157.2014.05.015]
 Meng Qingdong,Tao Hong..Macrophage apoptosis and diabetic atherosclerosis[J].International Journal of Endocrinology and Metabolism,2014,(05):340.[doi:10.3760/cma.j.issn.1673-4157.2014.05.015]
[9]赵荷珺 洪天配.胰高血糖素样肽-1类药物与胰腺安全性[J].国际内分泌代谢杂志,2015,(05):319.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.008]
 Zhao Hejun*,Hong Tianpei..Glucagon-like peptide-1-based therapies and pancreatic safety[J].International Journal of Endocrinology and Metabolism,2015,(05):319.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.008]
[10]吕丹 李晓思 陈树春 王泽普.Betatrophin:糖尿病再生治疗的新希望[J].国际内分泌代谢杂志,2015,(05):351.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.016]
 Lyu Dan*,Li Xiaosi,Chen Shuchun,et al.Betatrophin:new hope for regeneration therapy of diabetes[J].International Journal of Endocrinology and Metabolism,2015,(05):351.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.016]

备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81600600)
Fund program:National Natural Science Fundation of China(81600600)
作者单位:210028 南京中医药大学附属中西医结合医院内分泌代谢病院区,江苏省中医药研究院
通信作者:刘超,Email: liuchao@nfmcn.com
更新日期/Last Update: 2018-09-30