[1]毕会利 张慧娟.信号素3家族与糖尿病及其微血管并发症[J].国际内分泌代谢杂志,2018,38(02):110-112.[doi:10.3760/cma.j.issn.1673-4157.2018.02.010]
 Bi Huili,Zhang Huijuan..Class 3 semaphorins in diabetes mellitus and its microvascular complications[J].International Journal of Endocrinology and Metabolism,2018,38(02):110-112.[doi:10.3760/cma.j.issn.1673-4157.2018.02.010]
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信号素3家族与糖尿病及其微血管并发症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年02期
页码:
110-112
栏目:
综述
出版日期:
2018-03-20

文章信息/Info

Title:
Class 3 semaphorins in diabetes mellitus and its microvascular complications
作者:
毕会利 张慧娟
150001 哈尔滨医科大学附属第一医院内分泌科
Author(s):
Bi Huili Zhang Huijuan.
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
信号素3 糖尿病 糖尿病肾病 糖尿病视网膜病变
Keywords:
Semaphorin3 Diabetes mellitus Diabetic retinopathy Diabetic nephropathy
DOI:
10.3760/cma.j.issn.1673-4157.2018.02.010
摘要:
信号素最初被定义为神经系统发展中重要的轴突导向分子。近年来,研究发现,信号素3家族可通过影响胰岛素抵抗、炎性反应、病理性血管生成等过程参与糖尿病及糖尿病微血管病变,如糖尿病视网膜病变、糖尿病肾病的发生、发展,并有望为糖尿病并发症提供新的治疗靶点。
Abstract:
Semaphorins are initially identified as axon guidance molecules crucial for the development of the nervous system. Afterward, numerous studies have shown that they regulate other physiological and pathological processes other than the nervous system. In recent years, the researchers found that the class 3 semaphorins can affect the occurrence and development of diabetes mellitus and its microvascular complications such as diabetic retinopathy, diabtic nephropathy by influencing the process of insulin resistance, inflammatory reaction and pathological angiogenesis, and are expected to provide new therapeutic targets for diabetic complications.

参考文献/References:


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备注/Memo

备注/Memo:
基金项目:黑龙江省自然科学基金(H2016040)
通信作者:张慧娟,Email:hydzhj@126.com
更新日期/Last Update: 1900-01-01