[1]左姣 秦文 匡洪宇.钠摄入量与糖尿病尿白蛋白及肾小球滤过率[J].国际内分泌代谢杂志,2019,39(03):202-206.[doi:10.3760/cma.j.issn.1673-4157.2019.03.014]
 Zuo Jiao,Qin Wen,Kuang Hongyu.Sodium intake, diabetic urinary albumin and glomerular filtration rate[J].International Journal of Endocrinology and Metabolism,2019,39(03):202-206.[doi:10.3760/cma.j.issn.1673-4157.2019.03.014]
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钠摄入量与糖尿病尿白蛋白及肾小球滤过率()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年03期
页码:
202-206
栏目:
综述
出版日期:
2019-05-20

文章信息/Info

Title:
Sodium intake, diabetic urinary albumin and glomerular filtration rate
作者:
左姣 秦文 匡洪宇
哈尔滨医科大学第一临床医学院内分泌科 150001
Author(s):
Zuo Jiao Qin Wen Kuang Hongyu
Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China
关键词:
钠摄入量 糖尿病 尿白蛋白 肾小球滤过率
Keywords:
Sodium intake Diabetes mellitus Urinary albumin Glomerular filtration rate
DOI:
10.3760/cma.j.issn.1673-4157.2019.03.014
摘要:
饮食钠限制是预防或减缓糖尿病并发症发展的糖尿病护理的重要组成部分,许多国家糖尿病护理指南均提出了饮食钠摄入的建议,以期降低非传染病死亡率。然而,对于糖尿病患者饮食钠摄入量并无确切结论。对钠摄入量对糖尿病患者肾损伤的影响,包括近端肾小管对钠摄入量的敏感性变化、肾脏局部肾素-血管紧张素-醛固酮系统激活、胰岛素抵抗及相关细胞因子的释放进行总结,可为糖尿病患者肾损伤的预防和干预提出思路。
Abstract:
Dietary sodium restriction is an important part of diabetes care to prevent or slow down the development of diabetic complications. Diabetes care guidelines in many countries have proposed dietary sodium intake in order to reduce non-communicable disease mortality. However, there is no definite conclusion about dietary sodium intake in diabetic patients. Summarizes the effects of sodium intake on renal injury in diabetic patients, including changes in sensitivity of proximal tubules to sodium intake, activation of renin-angiotensin-aldosterone system in the kidney, insulin resistance and the release of related cytokines, could provide ideas for the prevention and intervention of kidney injury in diabetic patients.

参考文献/References:

[1] WHO.WHO global action plan for the prevention and control of noncommunicable diseases 2013-2020.Geneva:World Health Organization,2013.
[2] Brown IJ,Tzoulaki I,Candeias V,et al.Salt intakes around the world: implications for public health[J].Int J Epidemiol,2009,38(3):791-813.DOI:10.1093/ije/dyp139.
[3] Yan L,Guo X,Wang H,et al.Population-based association between urinary excretion of sodium, potassium and its ratio with albuminuria in Chinese[J].Asia Pac J Clin Nutr,2016,25(4):785-797.DOI:10.6133/apjcn.092015.33.
[4] Oh SW,Han KH,Han SY,et al.Association of sodium excretion with metabolic syndrome, insulin resistance, and body fat[J].Medicine(Baltimore),2015,94(39):e1650.DIO:10.1097/MD.0000000000001650.
[5] Suckling RJ,He FJ,Macgregor GA.Altered dietary salt intake for preventing and treating diabetic kidney disease[J].Cochrane Database Syst Rev,2010,(12):CD006763.DOI:10.1002/14651858.CD006763.pub2.
[6] Suckling RJ,He FJ,Markandu ND,et al.Modest salt reduction lowers blood pressure and albumin excretion in impaired glucose tolerance and type 2 diabetes mellitus:a randomized double-blind trial[J].Hypertension,2016,67(6):1189-1195. DOI:10.1161/HYPERTENSIONAHA.115.06637.
[7] Ohta Y,Tsuchihashi T,Kiyohara K,et al.High salt intake promotes a decline in renal function in hypertensive patients:a 10-year observational study[J].Hypertens Res,2013,36(2):172-176.DOI:10.1038/hr.2012.155.
[8] Nomura K,Asayama K,Jacobs L,et al.Renal function in relation to sodium intake: a quantitative review of the literature[J].Kidney Int,2017,92(1):67-78.DOI:10.1016/j.kint.2016.11.032.
[9] Luik PT,Hoogenberg K,Van Der Kleij FG,et al.Short-term moderate sodium restriction induces relative hyperfiltration in normotensive normoalbuminuric type Ⅰ diabetes mellitus[J].Diabetologia,2002,45(4):535-541.DOI:10.1007/s00125-001-0763-8.
[10] Kanauchi N,Ookawara S,Ito K,et al.Factors affecting the progression of renal dysfunction and the importance of salt restriction in patients with type 2 diabetic kidney disease[J].Clin Exp Nephrol,2015,19(6):1120-1126.DOI:10.1007/s10157-015-1118-y.
[11] Jaikumkao K,Pongchaidecha A,Chatsudthipong V,et al.The roles of sodium-glucose cotransporter 2 inhibitors in preventing kidney injury in diabetes[J].Biomed Pharmacother,2017,94:176-187.DOI:10.1016/j.biopha.2017.07.095.
[12] Vallon V,Schroth J,Satriano J,et al.Adenosine A(1)receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus[J].Nephron Physiol,2009,111(3):30-38.DOI:10.1159/000208211.
[13] Miracle CM,Rieg T,Mansoury H,et al.Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt[J].Am J Physiol Renal Physiol,2008,295(4):F995-F1002.DOI:10.1152/ajprenal.00491.2007.
[14] Delanaye P,Scheen AJ.Preventing and treating kidney disease in patients with type 2 diabetes[J].Expert Opin Pharmacother,2019,20(3):277-294.DOI:10.1080/14656566.2018.1551362.
[15] Zhao Y,Gao P,Sun F,et al.Sodium intake regulates glucose homeostasis through the PPARδ/adiponectin-mediated SGLT2 pathway[J].Cell Metab,2016,23(4):699-711.DOI:10.1016/j.cmet.2016.02.019.
[16] Yang X,Xiao X,Wang H,et al.Renoprotective effect of danhong injection on streptozotocin-induced diabetic ratsthrough a peroxisome proliferator-activated receptor γ mediated pathway[J].Evid Based Complement Alternat Med,2018,2018:3450141.DOI:10.1155/2018/3450141.
[17] Ibarra ME,Albertoni Borghese MF,Majowicz MP,et al.Concerted regulation of renal plasma flow and glomerular filtration rate by renaldopamine and NOS I in rats on high salt intake[J].Physiol Rep,2017,5(6).pii: e13202. DOI:10.14814/phy2.13202.
[18] Garagliano JM,Katsurada A,Miyata K,et al.Advanced glycation end products stimulate angiotensinogen production in renal proximal tubular cells[J].Am J Med Sci,2019,357(1):57-66.DOI:10.1016/j.amjms.2018.10.008.
[19] Schnermann J.Concurrent activation of multiple vasoactive signaling pathways in vasoconstriction caused by tubuloglomerular feedback: a quantitative assessment[J].Annu Rev Physiol,2015,77:301-322.DOI:10.1146/annurev-physiol-021014-071829.
[20] Rust P, Ekmekcioglu C. Impact of salt intake on the pathogenesis and treatment of hypertension[J].Adv Exp Med Biol,2017,956:61-84.DOI:10.1007/5584_2016_147.
[21] Regoli D,Gobeil F.Kallikrein-kinin system as the dominant mechanism to counteract hyperactive renin-angiotensin system[J].Can J Physiol Pharmacol,2017,95(10):1117-1124.DOI:10.1139/cjpp-2016-0619.
[22] Schweda F.Salt feedback on the renin-angiotensin-aldosterone system[J].Pflugers Arch,2015,467(3):565-576.DOI:10.1007/s00424-014-1668-y.
[23] Leenen FHH,Blaustein MP,Hamlyn JM.Update on angiotensin Ⅱ: new endocrine connections between the brain, adrenal glands and the cardiovascular system[J].Endocr Connect,2017,6(7):R131-R145.DOI:10.1530/EC-17-0161.
[24] Walsh KR,Kuwabara JT,Shim JW,et al.Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats[J].Am J Physiol Regul Integr Comp Physiol,2016,310(2):R115-R124.DOI:10.1152/ajpregu.00514.2014.
[25] Berger RC,Vassallo PF,Crajoinas Rde O,et al.Renal effects and underlying molecular mechanisms of long-term salt content diets in spontaneously hypertensive rats[J].PLoS One,2015,10(10):e0141288.DOI:10.1371/journal.pone.0141288.
[26] Birk C,Richter K,Huang DY,et al.The salt paradox of the early diabetic kidney is independent of renal innervation[J].Kidney Blood Press Res,2003,26(5-6):344-350.DOI:10.1159/000073941.
[27] Vallon V,Schroth J,Satriano J,et al.Adenosine A(1)receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitus[J].Nephron Physiol,2009,111(3):30-38.DOI:10.1159/000208211.
[28] Williams VR,Scholey JW.Angiotensin-converting enzyme 2 and renal disease[J].Curr Opin Nephrol Hypertens,2018,27(1):35-41.DOI:10.1097/MNH.0000000000000378.
[29] Østergaard MV,Pinto V,Stevenson K,et al.DBA2J db/db mice are susceptible to early albuminuria and glomerulosclerosis that correlate with systemic insulin resistance[J].Am J Physiol Renal Physiol,2017,312(2):F312-F321.DOI:10.1152/ajprenal.00451.2016.
[30] Jaldin-Fincati JR,Pavarotti M,Frendo-Cumbo S,et al.Update on GLUT4 vesicle traffic: a cornerstone of insulin action[J].Trends Endocrinol Metab,2017,28(8):597-611.DOI:10.1016/j.tem.2017.05.002.
[31] Graus-Nunes F,Souza-Mello V.The renin-angiotensin system as a target to solve the riddle of endocrine pancreashomeostasis[J].Biomed Pharmacother,2019,109:639-645.DOI:10.1016/j.biopha.2018.10.191.
[32] Premilovac D,Richards SM,Rattigan S,et al.A vascular mechanism for high-sodium-induced insulin resistance in rats[J].Diabetologia,2014,57(12):2586-2595.DOI:10.1007/s00125-014-3373-y.
[33] Stevens AL,Ferferieva V,Bito V,et al.Exercise improves cardiac function and attenuates insulin resistance in Dahl salt-sensitive rats[J].Int J Cardiol,2015,186:154-160.DOI:10.1016/j.ijcard.2015.03.094.
[34] Oh H,Lee HY,Jun DW,et al.Low salt diet and insulin resistance[J].Clin Nutr Res,2016,5(1):1-6.DOI:10.7762/cnr.2016.5.1.1.
[35] Iwasa N,Emoto N,Widyantoro B,et al.Knockout of endothelin-1 in vascular endothelial cells protects against insulinresistance induced by high-salt diet in mice[J].Kobe J Med Sci,2010,56(2):E85-E91.
[36] Perry CG,Palmer T,Cleland SJ,et al.Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin Ⅱ on insulin action[J].Clin Sci(Lond),2003,105(2):187-194.DOI:10.1042/CS20020320.
[37] Zhao Y,Gao P,Sun F,et al.Sodium intake regulates glucose homeostasis through the PPARδ/adiponectin-mediated SGLT2 pathway[J].Cell Metab,2016,23(4):699-711.DOI:10.1016/j.cmet.2016.02.019.
[38] Kern M,Klöting N,Mark M,et al.The SGLT2 inhibitor empagliflozin improves insulin sensitivity in db/db mice both as monotherapy and in combination with linagliptin[J].Metabolism,2016,65(2):114-123.DOI:10.1016/j.metabol.2015.10.010.
[39] Chan SMH,Lau YS,Miller AA,et al.Angiotensin Ⅱ causes β-cell dysfunction through an ER stress-induced proinflammatory response[J].Endocrinology,2017,158(10):3162-3173. DOI:10.1210/en.2016-1879.
[40] Oudot C,Lajoix AD,Jover B,et al.Dietary sodium restriction prevents kidney damage in high fructose-fed rats[J].Kidney Int,2013,83(4):674-683.DOI:10.1038/ki.2012.478.
[41] Lara LS,McCormack M,Semprum-Prieto LC,et al.AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG Ⅱ-salt hypertension[J].Am J Physiol Renal Physiol,2012,302(1):F85-F94.DOI:10.1152/ajprenal.00351.2011.
[42] Singh P,Castillo A,Islam MT,et al.Evidence for prohypertensive, proinflammatory effect of interleukin-10 during chronic high salt intake in the condition of elevated angiotensin Ⅱ level[J].Hypertension,2017,70(4):839-845.DOI:10.1161/HYPERTENSIONAHA.117.09401.
[43] Singh P,Bahrami L,Castillo A,et al.TNF-α type 2 receptor mediates renal inflammatory response to chronic angiotensin Ⅱ administration with high salt intake in mice[J].Am J Physiol Renal Physiol,2013,304(7):F991-F999.DOI:10.1152/ajprenal.00525.2012.
[44] Li X,Xing W,Wang Y,et al.Upregulation of caveolin-1 contributes to aggravated high-salt diet-induced endothelial dysfunction and hypertension in type 1 diabetic rats[J].Life Sci,2014,113(1-2):31-39.DOI:10.1016/j.lfs.2014.07.027.

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备注/Memo

备注/Memo:
通信作者:匡洪宇,Email:ydyneifenmier@163.com
Corresponding author: Kuang Hongyu, Email:ydyneifenmier@163.com
更新日期/Last Update: 2019-05-20