[1]傅雯雯 杨菊红 单春艳.血清心肌肌钙蛋白水平与糖尿病肾脏疾病的关系[J].国际内分泌代谢杂志,2019,39(03):198-201.[doi:10.3760/cma.j.issn.1673-4157.2019.03.013]
 Fu Wenwen,Yang Juhong,Shan Chunyan.Relationship between serum cardiac troponin and diabetic kidney disease[J].International Journal of Endocrinology and Metabolism,2019,39(03):198-201.[doi:10.3760/cma.j.issn.1673-4157.2019.03.013]
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血清心肌肌钙蛋白水平与糖尿病肾脏疾病的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年03期
页码:
198-201
栏目:
综述
出版日期:
2019-05-20

文章信息/Info

Title:
Relationship between serum cardiac troponin and diabetic kidney disease
作者:
傅雯雯 杨菊红 单春艳
天津医科大学代谢病医院糖尿病肾病科,国家卫生健康委员会激素与发育重点实验室(天津医科大学),天津市代谢性疾病重点实验室,天津医科大学代谢病医院内分泌研究所 300070
Author(s):
Fu WenwenYang JuhongShan Chunyan
Department of Diabetic Nephropathy, NHC Key Laboratory of Hormones and Development(Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, The Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China
关键词:
糖尿病肾病 肌钙蛋白 心肌梗死 心肌缺血
Keywords:
Diabetic kidney disease Troponin Myocardial infarction Myocardial ischemia
DOI:
10.3760/cma.j.issn.1673-4157.2019.03.013
摘要:
心肌肌钙蛋白(cTn)是心肌细胞损伤的特异性标志物之一。众所周知,其水平升高提示急性心肌梗死。近10年研究发现,cTn水平升高也存在于糖尿病肾脏疾病(DKD)患者中。目前研究认为,血清cTn水平升高与DKD之间的关系既互为因果,又可能同时发生。DKD患者血清cTn水平升高不仅提示亚临床心肌损伤,而且能够预测早期肾功能减退。因此,检测血清cTn水平有助于识别DKD人群中肾功能显著恶化的高危患者,指导临床医生实施针对性的决策。
Abstract:
Cardiac troponin(cTn)is one of the specific markers of myocyte damage. It is well known that elevated cTn level suggests acute myocardial infarction. In the last ten years, elevated cTn was found to be present in patients with diabetic kidney disease(DKD). It is generally accepted that the relationship between elevated cTn and DKD is reciprocal or coexistent. Elevated serum concentrations of cTn in patients with DKD not only suggests subclinical myocardial injury, but also predicts early renal dysfunction. Therefore, the detection of serum cTn is useful for identifying high-risk patients with deteriorating renal function in the patients with DKD and enabling individualized interventions.

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备注/Memo

备注/Memo:
通信作者:单春艳,Email:chunyanshan@hotmail.com
基金项目:国家自然科学基金(81473472); 天津市科技重大专项与工程(17ZXSCSY00060)
Corresponding author: Shan Chunyan, Email: chunyanshan@hotmail.com
Fund program:National Natural Science Foundation of China(81473472); Tianjin Major Science and Technology Projects(17ZXSCSY00060)
更新日期/Last Update: 2019-05-20