[1]方迎昕 周一军.环状RNA与糖尿病及其并发症[J].国际内分泌代谢杂志,2019,39(02):109-111,115.[doi:10.3760/cma.j.issn.1673-4157.2019.02.009]
　Fang Yingxin,Zhou Yijun.Circular RNAs, diabetes and its compications[J].International Journal of Endocrinology and Metabolism,2019,39(02):109-111,115.[doi:10.3760/cma.j.issn.1673-4157.2019.02.009]
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环状RNA与糖尿病及其并发症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年02期
页码:
109-111,115
栏目:
综述
出版日期:
2019-03-20

文章信息/Info

Title:
Circular RNAs, diabetes and its compications
作者:
方迎昕 周一军
中国医科大学附属第四医院内分泌代谢科,沈阳 110032
Author(s):
Fang Yingxin;  Zhou Yijun
Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
关键词:
环状RNA;  糖尿病;  糖尿病并发症;  生物标志物
Keywords:
Circular RNAs;  Diabetes mellitus;  Diabetic complications;  Biomarkers
DOI:
10.3760/cma.j.issn.1673-4157.2019.02.009
摘要:
现有的糖尿病的早期诊断指标存在一定缺陷,探寻新的高敏感性生物标志物有重要意义。环状RNA(circRNAs)具有分子海绵、调控转录、结合RNA结合蛋白等丰富的生物学功能,是糖尿病及其并发症,包括糖尿病视网膜病变、糖尿病肾病、糖尿病心血管病变、糖尿病痛性神经病变重要的调控分子,有望成为新兴糖尿病标志物和分子治疗靶点。
Abstract:
Current diagnostic methods show various insufficiencies for the early diagnosis of diabetes, thus a new and highly sensitive biomarker will be of great value. Circular RNAs(circRNAs)have multiple functions: acting as microRNA(miRNA)sponges, involving the regulation of gene transcription and binding with RNA-binding proteins. As the new regulatory molecules, circRNAs play an important role in diabetes and its complications, including diabetes retinopathy, diabetic nephropathy, dabetic cardiovascular complication, as well as diabetic neuropathic pain, and serve as the novel potential biomarkers as well as molecular tools for therapies.

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备注/Memo

备注/Memo:
通信作者:周一军,Email:zhoudoctor@163.com
基金项目:辽宁省自然科学基金(20170541029)
基金项目:辽宁省自然科学基金(20170541029)
Fund program:Natural Science Foundation of Liaoning Province of China(20170541029)
更新日期/Last Update: 2019-03-20