[1]方迎昕 周一军.长链非编码RNA与胰岛素抵抗的关系[J].国际内分泌代谢杂志,2018,38(06):412-414428.[doi:10.3760/cma.j.issn.1673-4157.2018.06.013]
 Fang Yingxin,Zhou Yijun.Relationship between long non-coding RNA and insulin resistance[J].International Journal of Endocrinology and Metabolism,2018,38(06):412-414428.[doi:10.3760/cma.j.issn.1673-4157.2018.06.013]
点击复制

长链非编码RNA与胰岛素抵抗的关系()
分享到:

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年06期
页码:
412-414428
栏目:
基础研究
出版日期:
2018-11-20

文章信息/Info

Title:
Relationship between long non-coding RNA and insulin resistance
作者:
方迎昕 周一军
作者单位:110032 沈阳,中国医科大学附属第四医院内分泌代谢科
Author(s):
Fang Yingxin Zhou Yijun
Department of Endocrinology and Metabolism, The Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
关键词:
长链非编码RNA 胰岛素抵抗 糖尿病
Keywords:
Long non-coding RNA Insulin resiatance Diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2018.06.013
摘要:
长链非编码RNA(lncRNA)作为一类长度超过200个核苷酸的功能性RNA,从表观遗传学、转录、转录后等水平调控基因的表达。近年来研究证实,一些lncRNA如Risa、MEG3、SRA、MALAT1、H19、Lethe等是参与胰岛素抵抗的重要调控分子。这些lncRNA将为胰岛素抵抗相关性疾病的诊治提供新靶点。
Abstract:
Long non-coding RNA(lncRNA)is a type of functional RNA with a length of more than 200 nucleotides and regulates gene expression from epigenetic, transcriptional, and posttranscriptional levels. Recent studies have confirmed that some lncRNAs such as Risa, MEG3, SRA, MALAT1, H19, Lethe are important regulatory molecules involved in insulin resistance. These lncRNAs will provide new targets for the diagnosis and treatment of insulin resistance-related diseases.

参考文献/References:


[1] Beat diabetes: an urgent call for global action[J].Lancet,2016,387(10027):1483. DOI:10.1016/S0140-6736(16)30185-4.
[2] Bunch H. Gene regulation of mammalian long non-coding RNA[J].Mol Genet Genomics,2018,293(1):1-15. DOI:10.1007/s00438-017-1370-9.
[3] Sallam T,Sandhu J,Tontonoz P.Long noncoding RNA discovery in cardiovascular disease: decoding form to function[J].Circ Res,2018,122(1):155-166.DOI:10.1161/CIRCRESAHA.117.311802.
[4] Engreitz JM,Haines JE,Perez EM,et al.Local regulation of gene expression by lncRNA promoters, transcription and splicing[J].Nature,2016,539(7629):452-455.DOI:10.1038/nature20149.
[5] Evans JR,Feng FY,Chinnaiyan AM.The bright side of dark matter: lncRNAs in cancer[J].J Clin Invest,2016,126(8):2775-2782.DOI:10.1172/JCI84421.
[6] 黄珊珊,鲁一兵.长链非编码RNA与糖尿病[J].国际内分泌代谢杂志,2015,35(4):271-274.DOI:10.3760/cma.j.issn.1673-4157.2015.04.016.
[7] Akhade VS,Pal D,Kanduri C.Long noncoding RNA: genome organization and mechanism of action[J].Adv Exp Med Biol,2017,1008:47-74.DOI:10.1007/978-981-10-5203-3_2.
[8] Zhang F,Zhang L,Zhang C.Long noncoding RNAs and tumorigenesis: genetic associations, molecular mechanisms, and therapeutic strategies[J].Tumour Biol,2016,37(1):163-175.DOI:10.1007/s13277-015-4445-4.
[9] Isin M,Dalay N.LncRNAs and neoplasia[J].Clin Chim Acta,2015,444:280-288.DOI:10.1016/j.cca.2015.02.046.
[10] Jiang W,Liu Y,Liu R,et al. The lncRNA DEANR1 facilitates human endoderm differentiation by activating FOXA2 expression[J].Cell Rep,2015,11(1):137-148.DOI:10.1016/j.celrep.2015.03.008.
[11] Pullen TJ,Rutter GA.Could lncRNAs contribute to β-cell identity and its ioss in type 2 diabetes[J].Biochem Soc Trans,2013,41(3):797-801.DOI:10.1042/BST20120355.
[12] Wang X,Chang X,Zhang P,et al.Aberrant expression of long non-coding RNAs in newly diagnosed type 2 diabetes indicates potential roles in chronic inflammation and insulin resistance[J].Cell Physiol Biochem,2017,43(6):2367-2378.DOI:10.1159/000484388.
[13] Yin DD,Zhang EB,You LH,et al. Downregulation of lncRNA TUG1 affects apoptosis and insulin secretion in mouse pancreatic β cells[J].Cell Physiol Biochem,2015,35(5):1892-1904.DOI:10.1159/000373999.
[14] Morán I,Akerman I,van de Bunt M,et al.Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes[J].Cell Metab,2012,16(4):435-448. DOI:10.1016/j.cmet.2012.08.010.
[15] Wang Y,Hu Y,Sun C,et al. Down-regulation of Risa improves insulin sensitivity by enhancing autophagy[J].FASEB J,2016,30(9):3133-3145.DOI:10.1096/fj.201500058R.
[16] Zhou Y,Zhang X,Klibanski A.MEG3 noncoding RNA: a tumor suppressor[J].J Mol Endocrinol,2012,48(3):R45-R53.DOI:10.1530/JME-12-0008.
[17] Zhu X,Wu YB,Zhou J,et al.Upregulation of lncRNA MEG3 promotes hepatic insulin resistance via increasing FoxO1 expression[J].Biochem Biophys Res Commun,2016,469(2):319-325.DOI:10.1016/j.bbrc.2015.11.048.
[18] Braconi C,Kogure T,Valeri N,et al.microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer[J].Oncogene,2011,30(47):4750-4756.DOI:10.1038/onc.2011.193.
[19] Bagge A,Clausen TR,Larsen S,et al. MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulatedinsulin secretion[J].Biochem Biophys Res Commun,2012,426(2):266-272.DOI:10.1016/j.bbrc.2012.08.082.
[20] Xu B,Gerin I,Miao H,et al.Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity[J].PLoS One,2010,5(12):e14199.DOI:10.1371/journal.pone.0014199.
[21] Liu S,Xu R,Gerin I,et al.SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling[J].PLoS One,2014,9(4):e95416. DOI:10.1371/journal.pone.0095416.
[22] Yan B,Tao ZF,Li XM,et al.Aberrant expression of long noncoding RNAs in early diabetic retinopathy[J].Invest Ophthalmol Vis Sci,2014,55(2):941-951.DOI:10.1167/iovs.13-13221.
[23] Yan C,Chen J,Chen N.Long noncoding RNA MALAT1 promotes hepatic steatosis and insulin resistance by increasing nuclear SREBP-1c protein stability[J].Sci Rep,2016,6:22640.DOI:10.1038/srep22640.
[24] Filozof C,Goldstein BJ,Williams RN,et al.Non-alcoholic steatohepatitis: limited available treatment options but promising drugs in development and recent progress towards a regulatory approval pathway[J].Drugs,2015,75(12):1373-1392.DOI:10.1007/s40265-015-0437-3.
[25] Leti F,Legendre C,Still CD,et al.Altered expression of MALAT1 lncRNA in nonalcoholic steatohepatitis fibrosis regulates CXCL5 in hepatic stellate cells[J].Transl Res,2017,190:25-39.e21.DOI:10.1016/j.trsl.2017.09.001.
[26] Gao Y,Wu F,Zhou J,et al.The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells[J].Nucleic Acids Res,2014,42(22):13799-13811.DOI:10.1093/nar/gku1160.
[27] Petry CJ,Evans ML,Wingate DL,et al.Raised late pregnancy glucose concentrations in mice carrying pups with targeted disruption of H19delta13[J].Diabetes,2010,59(1):282-286.DOI:10.2337/db09-0757.
[28] Kallen AN,Zhou XB,Xu J,et al.The imprinted H19 lncRNA antagonizes let-7 microRNAs[J].Mol Cell,2013,52(1):101-112.DOI:10.1016/j.molcel.2013.08.027.
[29] Zgheib C,Hodges MM,Hu J,et al.Long non-coding RNA lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages[J].PLoS One,2017,12(5):e0177453.DOI:10.1371/journal.pone.0177453.

相似文献/References:

[1]刘丹丹,王丽,史兴晔,等.脂肪酸受体GPR120影响胰岛素受体底物-1的表达[J].国际内分泌代谢杂志,2014,(06):371.[doi:10.3760/cma.j.issn.1673-4157.2014.06.003]
 Liu Dandan*,Wang Li,Shi Xingye,et al.Regulation of fatty acid receptor GPR120 on the expression of insulin receptor substrate-1[J].International Journal of Endocrinology and Metabolism,2014,(06):371.[doi:10.3760/cma.j.issn.1673-4157.2014.06.003]
[2]李新萍,张萍,李晓玉.螺内酯对特发性醛固酮增多症患者胰岛β细胞功能的影响[J].国际内分泌代谢杂志,2014,(06):379.[doi:10.3760/cma.j.issn.1673-4157.2014.06.005]
 Li Xinping,Zhang Ping,Li Xiaoyu..Effects of spironolactone on islet β cell function in patients with idiopathic hyperaldosteronism[J].International Journal of Endocrinology and Metabolism,2014,(06):379.[doi:10.3760/cma.j.issn.1673-4157.2014.06.005]
[3]胡雅琴,包玉倩.维生素D对非酒精性脂肪性肝病的保护作用[J].国际内分泌代谢杂志,2014,(06):408.[doi:10.3760/cma.j.issn.1673-4157.2014.06.013]
 Hu Yaqin,Bao Yuqian..Protective effect of vitamin D on non-alcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2014,(06):408.[doi:10.3760/cma.j.issn.1673-4157.2014.06.013]
[4]张琳,王晓琳,李小英.雄激素与糖脂代谢的关系[J].国际内分泌代谢杂志,2014,(05):351.[doi:10.3760/cma.j.issn.1673-4157.2014.05.018]
 Zhang Lin,Wang Xiaolin,Li Xiaoying..The relationship between testosterone and glycolipid,metabolism[J].International Journal of Endocrinology and Metabolism,2014,(06):351.[doi:10.3760/cma.j.issn.1673-4157.2014.05.018]
[5]梁绮君 余寿益 李淑华 胡晨鸣 杨焱.甲状腺结节与代谢综合征的相关性研究[J].国际内分泌代谢杂志,2015,(05):293.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.002]
 Liang Qijun,Yu Shouyi,Li Shuhua,et al.Association of thyroid nodule and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2015,(06):293.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.002]
[6]王锐 陆强 王术艺 朱东林 蒋韬 马宁 刘悦 李燕莉 贾晓娇 姚立新.血清25羟维生素D及vaspin水平与妊娠糖尿病关系的研究[J].国际内分泌代谢杂志,2015,(05):306.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.005]
 Wang Rui,Lu Qiang,Wang Shuyi,et al.Relationship between serum 25-hydroxyvitamin D, vaspin and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(06):306.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.005]
[7]黄祺 程海燕 卜瑞芳.1-磷酸鞘胺醇与胰岛素抵抗[J].国际内分泌代谢杂志,2015,(05):348.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.015]
 Huang Qi,Cheng Haiyan,Bu Ruifang..Sphingosine-1-phosphate and insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(06):348.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.015]
[8]李少卿 王坚.2型糖尿病患者血25-羟维生素D3缺乏 对胰岛素抵抗及骨量的影响[J].国际内分泌代谢杂志,2015,(06):384.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.006]
 Li Shaoqing*,Wang Jian..The influence of 25-hydroxyl vitamin D3 deficiency on insulin resistance and bone mass in patients with type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(06):384.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.006]
[9]李晶,董荣娜,于德民.有氧运动对胰岛素抵抗小鼠visfatin 表达的影响[J].国际内分泌代谢杂志,2016,36(01):10.[doi:10.3760/cma.j.issn.1673-4157.2016.01.003]
 Li Jing,Dong Rongna,Yu Demin..Effects of aerobic exercise on the expression of visfatin in mice with insulin resistance[J].International Journal of Endocrinology and Metabolism,2016,36(06):10.[doi:10.3760/cma.j.issn.1673-4157.2016.01.003]
[10]张琳,费雯婕,宋光耀.网膜素与代谢综合征[J].国际内分泌代谢杂志,2016,36(01):42.[doi:10.3760/cma.j.issn.1673-4157.2016.01.010]
 Zhang Lin*,Fei Wenjie,Song Guangyao..Omentin and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2016,36(06):42.[doi:10.3760/cma.j.issn.1673-4157.2016.01.010]

备注/Memo

备注/Memo:
基金项目:辽宁省自然科学基金(20170541029)
Fund program:Natural Science Foundation of Liaoning Province of China(20170541029)
作者单位:110032 沈阳,中国医科大学附属第四医院内分泌代谢科
通信作者:周一军,Email:zhoudoctor@163.com
更新日期/Last Update: 2018-12-30