[1]李少卿 王坚.2型糖尿病患者血25-羟维生素D3缺乏 对胰岛素抵抗及骨量的影响[J].国际内分泌代谢杂志,2015,(06):384-387.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.006]
　Li Shaoqing*,Wang Jian..The influence of 25-hydroxyl vitamin D3 deficiency on insulin resistance and bone mass in patients with type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(06):384-387.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.006]
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2型糖尿病患者血25-羟维生素D3缺乏 对胰岛素抵抗及骨量的影响()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年06期
页码:
384-387
栏目:
论著
出版日期:
2015-11-20

文章信息/Info

Title:
The influence of 25-hydroxyl vitamin D3 deficiency on insulin resistance and bone mass in patients with type 2 diabetes
作者:
李少卿 王坚
510515 广州,南方医科大学(李少卿); 528427 中山市广济医院内分泌科(李少卿); 210002 南京军区南京总医院内分泌科(王坚)
Author(s):
Li Shaoqing*; Wang Jian.
*Southern Medical University,Guangzhou 510515,China
关键词:
2型糖尿病;  25-羟维生素D3;  胰岛素抵抗;  骨量
Keywords:
Type 2 diabetes mellitus;  25-Hydroxy vitamin D3;  Insulin resistance;  Bone mass
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.06.006
摘要:
目的 探讨2型糖尿病患者血25-羟维生素D3[25(OH)D3]缺乏对胰岛素抵抗及骨量的影响。方法 选择2型糖尿病患者386例,以血25(OH)D3水平50 μg/L临界值分为维生素D缺乏组195例与正常组191例,进行血清25(OH)D3、血糖相关指标、骨密度、骨代谢生化指标检测,比较两组患者稳态模型评估-胰岛素抵抗指数(HOMA-IR)、稳态模型评估-胰岛素分泌指数(HOMA-B)与骨量相关指标,并分析25(OH)D3水平与HOMA-IR、HOMA-B及骨密度的相关性。结果 维生素D缺乏组HOMA-IR水平高于正常组,HOMA-B水平低于正常组,差异有统计学意义(t=2.78,9.43,P均<0.05); 维生素D缺乏组患者腰椎骨密度水平低于正常组,甲状旁腺激素水平高于正常组,差异有统计学意义(t=2.63,3.26,P均<0.05),两组患者钙磷乘积、碱性磷酸酶水平比较差异无统计学意义(P均>0.05); 维生素D缺乏组血清25(OH)D3水平与HOMA-IR呈负相关(r=-0.592,P<0.05),与HOMA-B及骨密度呈正相关(r=0.662,0.553,P均<0.05)。结论 血25(OH)D3缺乏可加重2型糖尿病患者胰岛素抵抗,增加骨量丢失。
Abstract:
Objective To explore the influence of 25-hydroxyl vitamin D3 deficiency on insulin resistance and bone mass in patients with type 2 diabetes.Methods A total of 386 patients with type 2 diabetes were divided into vitamin D deficiency group(195 cases)and normal group(191 cases)according to the plasma level of 25(OH)D3. The cut point was 50 μg/L. Blood 25(OH)D3, blood glucose related indicators, bone mineral density(BMD)and bone metabolism biochemical parameters were measured. Homeostasis model assessment-insulin resistance index(HOMA-IR), homeostasis model assessment-insulin secretion index(HOMA-B)and bone mass related indicators were compared between two groups. The correlation of 25(OH)D3 with HOMA-IR and HOMA-B were analyzed. Results HOMA-IR in vitamin D deficiency group was higher than that of normal group, while HOMA-B was lower than that in normal group; the difference were statistically significant(t=2.78,9.43,all P<0.05). BMD of lumbar spine in vitamin D deficiency group was lower than that in normal group, while the level of parathyroid hormone was higher than that in normal group; the difference were statistically significant(t=2.63,3.26,all P<0.05). Calcium-phosphorus product and alkaline phosphatase were not statistically different between two groups(all P>0.05). 25(OH)D3 was negatively correlated with HOMA-IR(r=-0.592,P<0.05),while was positively correlated with HOMA-B and BMD(r=0.662,0.553,all P<0.05)in vitamin D deficiency group. Conclusion The deficiency of blood 25(OH)D3 in type 2 diabetes patients can lead to the deterioration of insulin resistance and the acceleration of bone mass loss.

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备注/Memo

备注/Memo:
作者单位:510515 广州,南方医科大学(李少卿); 528427 中山市广济医院内分泌科(李少卿); 210002 南京军区南京总医院内分泌科(王坚) 通信作者:王坚,Email:wangjian23233@163.com
更新日期/Last Update: 2015-11-20