[1]张琳,王晓琳,李小英.雄激素与糖脂代谢的关系[J].国际内分泌代谢杂志,2014,(05):351-352.[doi:10.3760/cma.j.issn.1673-4157.2014.05.018]
　Zhang Lin,Wang Xiaolin,Li Xiaoying..The relationship between testosterone and glycolipid,metabolism[J].International Journal of Endocrinology and Metabolism,2014,(05):351-352.[doi:10.3760/cma.j.issn.1673-4157.2014.05.018]
点击复制

雄激素与糖脂代谢的关系()
分享到：

《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2014年05期
页码:
351-352
栏目:
小论坛
出版日期:
2014-10-31

文章信息/Info

Title:
The relationship between testosterone and glycolipid,metabolism
作者:
张琳; 王晓琳; 李小英
200025 上海交通大学医学院附属瑞金医院内分泌代谢科,上海市内分泌代谢病研究所
Author(s):
Zhang Lin; Wang Xiaolin;  Li Xiaoying.
Department of Endocrinology and Metabolism,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai Institute of Endocrinology and Metabolism,Shanghai 200025, China Corresponding author: Li Xiaoying, Email:xiaoying_li@hotmail.com
关键词:
雄激素;  胰岛素抵抗;  糖、脂代谢
Keywords:
Androgen;  Insulin resistance;  Glycolipid metabolism
DOI:
10.3760/cma.j.issn.1673-4157.2014.05.018
摘要:
雄激素是男性体内较为重要的一种激素,除维持男性特征外,还参与机体多种生理代谢过程,具有重要的物质代谢调节作用。男性雄激素水平低下,可增加代谢综合征、2型糖尿病、动脉粥样硬化等代谢性疾病的发病率。此外,女性雄激素水平升高与胰岛素抵抗及脂代谢紊乱也有关,雄激素对血糖、血脂、脂肪细胞因子和机体组分均可产生重要影响。
Abstract:
Testosterone is an important hormone in men since it not only keeps masculinity and participates in a variety of physiological processes, but also regulates metabolism.Low level of androgen increases the risk of metabolic syndrome, type 2 diabetes, as well as the incidence of atherosclerosis and other metabolic diseases in men.On the other hand, elevated androgen level in women is associated with insulin resistance and dyslipidemia.Androgen can also affect blood glucose, lipids, adipocytokines and body components.

参考文献/References:

[1] 李松珊,李晶,徐涛,等.雄激素与代谢相关疾病的研究进展[J].生理科学进展, 2011,42(3):205-209.
[2] Kelly DM, Jones TH. Testosterone: a metabolic hormone in health and disease[J].J Endocrinol, 2013,217(3):R25-R45.
[3] Ayonrinde OT, Olynyk JK, Beilin LJ, et al. Gender-specific differences in adipose distribution and adipocytokines influence adolescent nonalcoholic fatty liver disease[J].Hepatology, 2011,53(3):800-809.
[4] Saad F, Gooren LJ. The role of testosterone in the etiology and treatment of obesity, the metabolic syndrome, and diabetes mellitus type 2[J].J Obes,2011, 2011,pii: 471584.
[5] Rubinow KB, Snyder CN, Amory JK, et al. Acute testosterone deprivation reduces insulin sensitivity in men[J]. Clin Endocrinol(Oxf), 2012,76(2):281-288.
[6] Rao PM, Kelly DM, Jones TH.Testosterone and insulin resistance in the metabolic syndrome and T2DM in men[J].Nat Rev Endocrinol, 2013, 9(8):479-493.
[7] Salam HS, Köse O, Kumsar S, et al. Fasting blood glucose and lipid profile alterations following twelve-month androgen deprivation therapy in men with prostate cancer[J].ScientificWorldJournal,2012,2012:696329.
[8] Roayaei M, Ghasemi S. Effect of androgen deprivation therapy on cardiovascular risk factors in prostate Cancer[J]. J Res Med Sci, 2013,18(7):580-582.
[9] Allan CA. Sex steroids and glucose metabolism[J]. Asian J Androl, 2014,16(2):232-238.
[10] Fahed AC, Gholmieh JM, Azar ST. Connecting the Lines between hypo- gonadism and atherosclerosis[J].Int J Endocrinol, 2012, 2012:793953.
[11] Yialamas MA, Dwyer AA, Hanley E, et al. Acute sex steroid withdrawal reduces insulin sensitivity in healthy men with idiopathic hypogonadotropic hypogonadism[J].J Clin Endocrinol Metab, 2007,92(11):4254-4259.
[12] Kapoor D,Goodwin E,Channer KS, et al. Testosterone replacement therapy improves insulin resistance, glycaemiccontrol,visceraladiposityandhyper- cholesterolaemia in hypogonadal men with type 2 diabetes[J]. Eur J Endocrinol, 2006,154(6):899-906.
[13] Kianifard D, Sadrkhanlou RA, Hasanzadeh S. The ultrastructural changes of the sertoli and leydig cells following streptozotocin induced diabetes[J].Iran J Basic Med Sci, 2012,15(1):623-635.
[14] O'reilly MW, Taylor AE, Crabtree NJ, et al. Hyperandrogenemia predicts metabolic phenotype in polycystic ovary syndrome: the utility of serum androstenedione[J]. J Clin Endocrinol Metab, 2014,99(3):1027-1036.
[15] Alpad M, Fernf E, Escobar-Morreale HF. Androgens andpolycystic ovary syndrome[J]. Expert Rev Endocrinol Metab,2012,7:91-102.
[16] Kozakowski J, Zgliczyński W. Body composition, glucose metabolism markers and serum androgens - association in women with polycystic ovary syndrome[J]. Endokrynol Pol, 2013,64(2):94-100
[17] Pourteymour Fard Tabrizi F,Alipoor B, Mehrzad Sadaghiani M, et al. Metabolic syndrome and its characteristics among reproductive-aged women with polycystic ovary syndrome: A cross-sectional study in Northwest Iran[J].Int J Fertil Steril,2013,6(4):244-249.
[18] Zhang J, Fan P, Liu H, et al. Apolipoprotein A-Ⅰ and B levels, dyslipidemia and metabolic syndrome in south-west Chinese women with PCOS[J]. Hum Reprod, 2012,27(8):2484-2493.
[19] Chen X, Jia X, Qiao J, et al. Adipokines in reproductive function: a Link between obesity and polycystic ovary syndrome[J]. J Mol Endocrinol, 2013,50(2):R21-R37.

相似文献/References:

[1]刘丹丹,王丽,史兴晔,等.脂肪酸受体GPR120影响胰岛素受体底物-1的表达[J].国际内分泌代谢杂志,2014,(06):371.[doi:10.3760/cma.j.issn.1673-4157.2014.06.003]
　Liu Dandan*,Wang Li,Shi Xingye,et al.Regulation of fatty acid receptor GPR120 on the expression of insulin receptor substrate-1[J].International Journal of Endocrinology and Metabolism,2014,(05):371.[doi:10.3760/cma.j.issn.1673-4157.2014.06.003]
[2]李新萍,张萍,李晓玉.螺内酯对特发性醛固酮增多症患者胰岛β细胞功能的影响[J].国际内分泌代谢杂志,2014,(06):379.[doi:10.3760/cma.j.issn.1673-4157.2014.06.005]
　Li Xinping,Zhang Ping,Li Xiaoyu..Effects of spironolactone on islet β cell function in patients with idiopathic hyperaldosteronism[J].International Journal of Endocrinology and Metabolism,2014,(05):379.[doi:10.3760/cma.j.issn.1673-4157.2014.06.005]
[3]胡雅琴,包玉倩.维生素D对非酒精性脂肪性肝病的保护作用[J].国际内分泌代谢杂志,2014,(06):408.[doi:10.3760/cma.j.issn.1673-4157.2014.06.013]
　Hu Yaqin,Bao Yuqian..Protective effect of vitamin D on non-alcoholic fatty liver disease[J].International Journal of Endocrinology and Metabolism,2014,(05):408.[doi:10.3760/cma.j.issn.1673-4157.2014.06.013]
[4]梁绮君 余寿益 李淑华 胡晨鸣 杨焱.甲状腺结节与代谢综合征的相关性研究[J].国际内分泌代谢杂志,2015,(05):293.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.002]
　Liang Qijun,Yu Shouyi,Li Shuhua,et al.Association of thyroid nodule and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2015,(05):293.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.002]
[5]王锐 陆强 王术艺 朱东林 蒋韬 马宁 刘悦 李燕莉 贾晓娇 姚立新.血清25羟维生素D及vaspin水平与妊娠糖尿病关系的研究[J].国际内分泌代谢杂志,2015,(05):306.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.005]
　Wang Rui,Lu Qiang,Wang Shuyi,et al.Relationship between serum 25-hydroxyvitamin D, vaspin and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(05):306.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.005]
[6]黄祺 程海燕 卜瑞芳.1-磷酸鞘胺醇与胰岛素抵抗[J].国际内分泌代谢杂志,2015,(05):348.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.015]
　Huang Qi,Cheng Haiyan,Bu Ruifang..Sphingosine-1-phosphate and insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(05):348.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.015]
[7]李少卿 王坚.2型糖尿病患者血25-羟维生素D3缺乏 对胰岛素抵抗及骨量的影响[J].国际内分泌代谢杂志,2015,(06):384.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.006]
　Li Shaoqing*,Wang Jian..The influence of 25-hydroxyl vitamin D3 deficiency on insulin resistance and bone mass in patients with type 2 diabetes[J].International Journal of Endocrinology and Metabolism,2015,(05):384.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.06.006]
[8]李晶,董荣娜,于德民.有氧运动对胰岛素抵抗小鼠visfatin 表达的影响[J].国际内分泌代谢杂志,2016,36(01):10.[doi:10.3760/cma.j.issn.1673-4157.2016.01.003]
　Li Jing,Dong Rongna,Yu Demin..Effects of aerobic exercise on the expression of visfatin in mice with insulin resistance[J].International Journal of Endocrinology and Metabolism,2016,36(05):10.[doi:10.3760/cma.j.issn.1673-4157.2016.01.003]
[9]张琳,费雯婕,宋光耀.网膜素与代谢综合征[J].国际内分泌代谢杂志,2016,36(01):42.[doi:10.3760/cma.j.issn.1673-4157.2016.01.010]
　Zhang Lin*,Fei Wenjie,Song Guangyao..Omentin and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2016,36(05):42.[doi:10.3760/cma.j.issn.1673-4157.2016.01.010]
[10]汤玮娜,任寿安.间歇低氧对大鼠胰岛素抵抗及骨骼肌细胞 GLUT4、Akt2的影响[J].国际内分泌代谢杂志,2016,36(02):112.[doi:10.3760/cma.j.issn.1673-4157.2016.02.009]
　Tang Weina*,Ren Shou'an..Effects of intermittent hypoxia on insulin resistance and expression of GLUT4 and Akt2 in skeletal muscle cells of rats[J].International Journal of Endocrinology and Metabolism,2016,36(05):112.[doi:10.3760/cma.j.issn.1673-4157.2016.02.009]

备注/Memo

备注/Memo:
通信作者:李小英:Email: xiaoying_li@hotmail.com
更新日期/Last Update: 2014-09-20