[1]黄祺 程海燕 卜瑞芳.1-磷酸鞘胺醇与胰岛素抵抗[J].国际内分泌代谢杂志,2015,(05):348-350.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.015]
 Huang Qi,Cheng Haiyan,Bu Ruifang..Sphingosine-1-phosphate and insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(05):348-350.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.015]
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1-磷酸鞘胺醇与胰岛素抵抗()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年05期
页码:
348-350
栏目:
基础研究
出版日期:
2015-09-20

文章信息/Info

Title:
Sphingosine-1-phosphate and insulin resistance
作者:
黄祺 程海燕 卜瑞芳
214023 无锡,南京医科大学附属无锡人民医院内分泌科
Author(s):
Huang QiCheng HaiyanBu Ruifang.
Department of Endocrinology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023,China
关键词:
1-磷酸鞘胺醇 神经酰胺 胰岛素抵抗
Keywords:
Sphingosine-1-phosphate Ceramide Insulin resistance
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.05.015
摘要:
1-磷酸鞘胺醇(S1P)是神经酰胺代谢产生的一种生物活性脂质。它不仅是细胞外介质,也是细胞内第二信使,参与细胞的增殖、分化等生理过程。S1P与不同的受体结合产生的作用各异。研究表明其可以通过不同的途径参与胰岛素信号的调节,对胰岛素信号产生不同的影响,与肝脏、骨骼肌、胰岛等组织胰岛素抵抗的发生密切相关。
Abstract:
Sphingosine-1-phosphate(S1P)is a bioactive lipid metabolite of ceramide. It is not only the extracellular mediator, but also the intracellular second messenger involved in cell proliferation, differentiation, and other physiological processes.S1P has various effects when combining to different receptors. Studies have showed that it plays a role in insulin signaling regulation by diverse ways resulting in different influence. It is closely correlated with insulin resistance in liver, skeletal muscle, islet and so on.

参考文献/References:

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备注/Memo

备注/Memo:
作者单位:214023 无锡,南京医科大学附属无锡人民医院内分泌科 通信作者:卜瑞芳,Email:brfang2003@163.com
更新日期/Last Update: 2015-09-20