[1]梁绮君 余寿益 李淑华 胡晨鸣 杨焱.甲状腺结节与代谢综合征的相关性研究[J].国际内分泌代谢杂志,2015,(05):293-297.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.002]
　Liang Qijun,Yu Shouyi,Li Shuhua,et al.Association of thyroid nodule and metabolic syndrome[J].International Journal of Endocrinology and Metabolism,2015,(05):293-297.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.002]
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甲状腺结节与代谢综合征的相关性研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年05期
页码:
293-297
栏目:
论著
出版日期:
2015-09-20

文章信息/Info

Title:
Association of thyroid nodule and metabolic syndrome
作者:
梁绮君 余寿益 李淑华 胡晨鸣 杨焱
528000 佛山市中医院健康管理中心
Author(s):
Liang Qijun;  Yu Shouyi;  Li Shuhua;  Hu Chenming;  Yang Yan.
Department of Health Management Center, Foshan Hospital of Traditional Chinese Medicine, Foshan 528000, China
关键词:
甲状腺结节;  代谢综合征;  胰岛素抵抗
Keywords:
Thyroid nodule;  Metabolic syndrome;  Insulin resistance
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.05.002
摘要:
目的 研究甲状腺结节与代谢综合征(MS)及其组分的关系,并对其机制进行探讨。方法 回顾性分析2014年佛山市中医院的3 855名体检者的体检资料。将体检者分别分成MS组和非MS组,胰岛素低抗(IR)组和非IR组。检测身高、体重、血压、空腹血糖、血脂、尿酸等指标。检测促甲状腺激素(TSH)、游离T3、游离T4以评估甲状腺功能。检测空腹血清胰岛素水平,计算稳态模型评估-胰岛素抵抗指数(HOMA-IR),以评估IR情况。使用彩色多普勒超声检查脂肪肝及甲状腺结节的患病情况。结果(1)共1 455人患甲状腺结节,患病率37.74%。女性患病率高于男性(46.57% vs.32.28%, χ2=79.073,P<0.01)。按年龄分层,在70岁以下人群,甲状腺结节的患病率随年龄增长而上升(P<0.05)。(2)MS组的甲状腺结节患病率显著高于非MS组(50.14% vs. 36.47%, χ2=25.888,P<0.01)。MS组分超重、高血糖、高血压患者的甲状腺结节患病率也显著升高(42.15% vs. 36.06%, χ2=12.515,P<0.01; 49.92% vs.35.46%,χ2=45.623,P<0.01; 57.57% vs. 35.84%,χ2=61.759,P<0.01)。(3)MS组血清TSH及HOMA-IR水平明显高于非MS组(t=4.763,P<0.01; t=5.028,P<0.01)。(4)IR组的甲状腺结节患病率显著高于非IR组(67.00% vs. 33.32%, χ2=212.115,P<0.01)。(5)多因素Logistic逐步回归分析显示,甲状腺结节的发生与性别、年龄、体重指数、收缩压、MS、IR独立相关(β=0.751,P<0.01; β=0.061,P<0.01; β=0.062,P<0.01; β=0.006,P=0.047; β=0.069,P<0.01; β=0.725,P<0.01),与TSH无明显相关。结论 MS患者的甲状腺结节患病率显著升高,其机制可能与IR有关。
Abstract:
Objective To investigate the association of thyroid nodule with metabolic syndrome(MS)and its components, and analyze the underlying mechanism.Methods A total of 3 855 subjects who received physical examination at Foshan Hospital of Traditional Chinese Medicine in 2014 were enrolled in this retrospective study, and were divided into MS group, non-MS group, insulin resistance(IR)group and non-IR group, respectively. Height, weight, blood pressure, fasting blood glucose, serum lipid profile and urine acid were measured. Thyroid function was evaluated by measuring serum thyroid stimulating hormone(TSH), free tri-iodothyronine(FT3)and thyroxine(FT4). Fasting plasma insulin was also measured. IR was estimated by homeostasis model assessment-insulin resistance(HOMA-IR). Fatty liver and thyroid nodules were detected by color Doppler ultrasonography. Results(1)Thyroid nodules were found in 1 455 subjects. The overall prevalence of thyroid nodule was 37.74%. The prevalence of thyroid nodules in women was significantly higher than that in men(46.57% vs. 32.28%, χ2=79.073,P<0.01). In those younger than 70 years old, the prevalence of thyroid nodule increased with age(P<0.05).(2)The prevalence of thyroid nodule was significantly higher in MS group than that in non-MS group(50.14% vs. 36.47%, χ2=25.888,P<0.01). Patients with MS components including overweight, hyperglycemia or hypertension also had higher thyroid nodule prevalence(42.15% vs. 36.06%, χ2=12.515, P<0.01; 49.92% vs. 35.46%, χ2=45.623, P<0.01; 57.57% vs. 35.84%, χ2=61.759, P<0.01).(3)Serum TSH and HOMA-IR were significantly higher in MS group than those in non-MS group(t=4.763,P<0.01; t=5.028,P<0.01).(4)Compared with non-IR group, the prevalence of thyroid nodule in IR group was higher(67.00% vs. 33.32%, χ2=212.115, P<0.01).(5)In multivariate Logistic regression analysis, factors which were independently correlated with thyroid nodule formation were age, sex, body mass index, systolic blood pressure, MS as well as IR(β=0.751, P<0.01; β=0.061, P<0.01; β=0.062,P<0.01; β=0.006, P=0.047; β=0.069,P<0.01; β=0.725,P<0.01), but not TSH.Conclusion The prevalence of thyroid nodule in patients with MS is increased, which might be associated with IR.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:广东省科技厅项目(2013B022000023) 作者单位:528000 佛山市中医院健康管理中心
更新日期/Last Update: 2015-09-20