[1]王锐 陆强 王术艺 朱东林 蒋韬 马宁 刘悦 李燕莉 贾晓娇 姚立新.血清25羟维生素D及vaspin水平与妊娠糖尿病关系的研究[J].国际内分泌代谢杂志,2015,(05):306-308.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.005]
　Wang Rui,Lu Qiang,Wang Shuyi,et al.Relationship between serum 25-hydroxyvitamin D, vaspin and gestational diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2015,(05):306-308.[doi:DOI:10.3760/cma.j.issn.1673-4157.2015.05.005]
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血清25羟维生素D及vaspin水平与妊娠糖尿病关系的研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年05期
页码:
306-308
栏目:
论著
出版日期:
2015-09-20

文章信息/Info

Title:
Relationship between serum 25-hydroxyvitamin D, vaspin and gestational diabetes mellitus
作者:
王锐 陆强 王术艺 朱东林 蒋韬 马宁 刘悦 李燕莉 贾晓娇 姚立新
066000 河北秦皇岛市第一医院内分泌科
Author(s):
Wang Rui; Lu Qiang; Wang Shuyi; Zhu Donglin; Jiang Tao; Ma Ning; Liu Yue; Li Yanli; Jia Xiaojiao; Yao Lixin
Department of Endocrinology, The First Hospital of Qinhuangdao,Qinhuangdao 066000,China
关键词:
妊娠糖尿病;  25羟维生素D;  Vaspin;  胰岛素抵抗
Keywords:
Gestational diabetes mellitus;  25-Hydroxyvitamin D;  Vaspin;  Insulin resistance
DOI:
DOI:10.3760/cma.j.issn.1673-4157.2015.05.005
摘要:
目的 探讨血清25羟维生素D[25(OH)D]及vaspin与妊娠糖尿病的关系。方法 选取妊娠24～28周的女性244名,根据口服葡萄糖耐量试验(OGTT)的结果,分为正常妊娠组(n=102)、妊娠糖尿病组(n=142),同时选择正常非妊娠女性90名作为对照组。分别检测各组空腹血糖、甘油三酯、总胆固醇、空腹胰岛素(FINS)、血清25(OH)D含量和vaspin水平,并计算稳态模型评估-胰岛素抵抗指数(HOMA-IR)。分析25(OH)D与vaspin、空腹胰岛素及HOMA-IR的相关性。结果 妊娠糖尿病组空腹血糖水平、HOMA-IR较正常妊娠组及对照组升高(F=39.402,12.147,P均<0.05); 妊娠糖尿病组及正常妊娠组甘油三酯、总胆固醇及FINS水平较对照组升高(F=79.915,56.695,9.985,P均<0.05)。妊娠糖尿病组25(OH)D水平较正常妊娠组及对照组降低(F=50.875,P<0.05),而vaspin水平较正常妊娠组及对照组升高(F=30.678,P<0.05); 且25(OH)D水平与FINS(r=-0.913,P=0.012)、HOMA-IR(r=-0.181,P=0.019)呈负相关,与vaspin(r=-0.084,P=0.279)水平无关,vaspin水平与空腹血糖(r=0.208,P=0.007)、FINS(r=0.352,P=0.000)、HOMA-IR(r=0.366,P=0.000)呈正相关。Logistic回归分析显示25(OH)D缺乏是妊娠糖尿病的独立危险因素。结论 妊娠糖尿病患者血清25(OH)D水平降低,vaspin水平升高。血清25(OH)D可能影响胰岛β细胞功能,参与妊娠糖尿病的发展。
Abstract:
Objective To investigate the relationship between serum 25-hydroxyvitamin D[25(OH)D],vaspin and gestational diabetes mellitus(GDM).Methods A total of 244 pregnant women at 24-28 weeks of gestation were divided into normal pregnant group(n=102)and GDM group(n=142)according to the results of oral glucose tolerance test(OGTT), and 90 normal non-pregnant women were served as control. Fasting plasma glucose, triglycerides, cholesterol, fasting insulin, 25(OH)D and vaspin levels were measured.The homeostasis model assessment-insulin resistance(HOMA-IR)were calculated.The relationship between 25(OH)D and vaspin, FINS, HOMA-IR were analyzed.Results The levels of fasting plasma glucose and HOMA-IR in GDM group were higher than those in normal pregnant group and control group(F=39.402,2.147,all P<0.05). Triglycerides, cholesterol and fasting insulin in GDM group and normal pregnant group were higher than those in control group(F=79.915,56.695, 9.985, all P<0.05). The level of 25(OH)D in GDM group was lower than that in normal pregnant group and control group(F=50.875,P<0.05). The level of vaspin in GDM group was higher than that in normal pregnant group and control group(F=30.678,P<0.05). Serum 25(OH)D level was negatively correlated with FINS(r=-0.913,P=0.012)and HOMA-IR(r=-0.181,P=0.019),and had no correlation with the level of vaspin(r=-0.084,P=0.279).Serum vaspin level was positively correlated with fasting plasma glucose(r=0.208,P=0.007),FINS(r=0.352,P=0.000)and HOMA-IR(r=0.366, P=0.000). Logistic regression analysis showed that lack of 25(OH)D was an independent risk factor for GDM. Conclusions Serum 25(OH)D decreases while serum vaspin level increases in patients with GDM.Serum 25(OH)D may have impacts on the function of islet β cell, and then contributes to the development of GDM.

参考文献/References:

[1] Danescu LG,Levy S,Levy J.Vitamin D and diabetes mellitus[J].Endocrine,2009,35(1):11-17. [/br][2] American Diabetes Association.Standards of medical care in diabetes-2012[J].Diabetes Care,2012,35(Suppl 1): S11-S63. [/br][3] 苏玉霞,洪洁.妊娠糖尿病发病机制研究进展[J].国际内分泌代谢杂志,2008,28(Suppl):53-55. [/br][4] Soheilykhah S,Mojibian M,Rashidi M,et al.Maternal vitamin D status in gestational diabetes mellitus[J].Nutr Clin Pract,2010,25(5):524-527. [/br][5] Zhang C,Qiu C,Hu FB,et al.Maternal plasma 25-hydroxyvitamin D concentrations and the risk for gestational diabetes mellitus[J].PLoS One, 2008,3(11):e3753. [/br][6] Thorand B,Zierer A,Huth C,et al.Effect of serum 25-hydroxyvitamin D on risk for type 2 diabetes may be partially mediated by subclinical inflammation:results from the MONICA/KORA Augsburg study[J].Diabetes Care,2011,34(10):2320-2322. [/br][7] 贾晓娇,陆强. 脂肪因子与妊娠糖尿病[J].国际内分泌代谢杂志,2013,33(1):46-49. [/br][8] El-Mesallamy HO,Kassem DH,El-Demerdash E,et al.Vaspin and visfatin/Nampt are interesting interrelated adipokines playing a role in the pathogensis of type 2 diabetes mellitus[J].Metabolism,2011,60(1):63-70. [/br][9] Gulcelik NE,Karakaya J,Gedik A,et al.Serum vaspin levels in type 2 diabetic women in relation to microvascular complications[J]. Eur J Endocrinol,2009,160(1):65-70. [/br][10] Suleymanoglu S, Tascilar E, Pirgon O, et al.Vaspin and its correlation with insulin sensitivity indices in obese children[J].Diabetes Res Clin Pract,2009,84(3):325-328. [/br][11] Stepan H, Kralisch S, Klostemann K,et al. Preliminary report:circulating levels of the adipokine vaspin in gcstational diabetes mellitus and preeclampsia. Metabolism, 2010, 59:1054-1056.

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备注/Memo

备注/Memo:
作者单位:066000 河北秦皇岛市第一医院内分泌科 通信作者:陆强,Email:sljwr@163.com
更新日期/Last Update: 2015-09-20