[1]冯俊杰,戴阳丽,王秀敏.MIN6细胞系的细胞学特性及其应用[J].国际内分泌代谢杂志,2016,36(02):135-138.[doi:10.3760/cma.j.issn.1673-4157.2016.02.014]
 Feng Junjie,Dai Yangli,Wang Xiumin..Cytological characteristics and application of MIN6 cell line[J].International Journal of Endocrinology and Metabolism,2016,36(02):135-138.[doi:10.3760/cma.j.issn.1673-4157.2016.02.014]
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MIN6细胞系的细胞学特性及其应用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年02期
页码:
135-138
栏目:
综述
出版日期:
2016-03-20

文章信息/Info

Title:
Cytological characteristics and application of MIN6 cell line
作者:
冯俊杰戴阳丽王秀敏
310003 杭州,浙江大学附属儿童医院内分泌科(冯俊杰,戴阳丽,王秀敏); 314001 浙江省嘉兴市第一医院儿科(冯俊杰); 200127 上海儿童医学中心(王秀敏)
Author(s):
Feng Junjie Dai Yangli Wang Xiumin.
Department of Endocrinology, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou 310003, China
关键词:
MIN6 糖尿病 细胞学特性 自噬
Keywords:
MIN6 Diabetes mellitus Cytological characteristics Autophagy
DOI:
10.3760/cma.j.issn.1673-4157.2016.02.014
摘要:
MIN6细胞系是从表达类人猿病毒40大T抗原(受胰岛毒启动子控制)的转基因非肥胖糖尿病小鼠胰岛瘤中建立的,其内分泌功能与胰腺组织非常接近,是研究胰岛细胞功能的理想模型。MIN6细胞系可用于胰腺分泌的研究,β细胞的适宜刺激信号的探索; 1型糖尿病发病机制的研究; 氧化应激、自噬、游离脂肪酸对2型糖尿病发病的影响; 在胰腺移植后发生排斥的机制研究。
Abstract:
MIN6 cell line is established from insulinomas obtained by targeted expression of the simian virus 40 T antigen in transgenic non-obese diabetic mice. The endocrine function of MIN6 cells is similar to pancreatic tissue, which makes it an ideal model in researching the function of islet cells. The MIN6 cell line is used in pancreatic secretion in recent years, and also in finding stimulus signal to β cells. MIN6 cell line is used to study the pathogenesis of type 1 diabetes as well as the effects of oxidative stress, autophagy and free fatty acids on the pathogenesis of type 2 diabetes. At the same time, it can be used to discuss the mechanism in reject reaction after pancreas transplantation.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(30971125,81370930)
更新日期/Last Update: 2016-03-20