[1]戴程婷 李一卉 袁逸 袁庆新.宫内发育迟缓导致成年糖尿病的研究进展[J].国际内分泌代谢杂志,2019,39(04):257-260.[doi:10.3760/cma.j.issn.1673-4157.2019.04.010]
　Dai Chengting,Li Yihui,Yuan Yi,et al.Research progress on the study of intrauterine growth restriction and adult diabetes[J].International Journal of Endocrinology and Metabolism,2019,39(04):257-260.[doi:10.3760/cma.j.issn.1673-4157.2019.04.010]
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宫内发育迟缓导致成年糖尿病的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年04期
页码:
257-260
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Research progress on the study of intrauterine growth restriction and adult diabetes
作者:
戴程婷 李一卉 袁逸 袁庆新
南京医科大学第一附属医院内分泌科 210029
Author(s):
Dai Chengting;  Li Yihui;  Yuan Yi;  Yuan Qingxin
Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical Unversity, Nanjing 210029, China
关键词:
宫内发育迟缓;  糖尿病;  表观遗传;  氧化应激;  内质网应激
Keywords:
Intrauterine growth restriction;  Diabetes mellitus;  Epigenomics;  Oxidative stress;  Endoplasmic reticulum stress
DOI:
10.3760/cma.j.issn.1673-4157.2019.04.010
摘要:
宫内发育异常在糖尿病发病中的作用受到越来越多的关注。宫内发育迟缓(IUGR)胎儿可能出现胰腺发育异常,出生后胰岛功能进一步下降,成年后易发生糖尿病。IUGR发展为糖尿病有众多因素参与,近来表观遗传学指出,胰腺细胞发育过程中的甲基化水平改变、组蛋白修饰减少以及RNA编辑异常等可影响胰腺分化和增殖,导致胰岛发育异常,可能诱发成年糖尿病。而孕期营养补充和运动等早期干预可以预防糖尿病的发生。
Abstract:
Intrauterine growth restriction(IUGR)may lead to abnormal development of pancreata in the IUGR fetus. The islet function is further reduced after birth, and diabetes is prone to occur in adulthood. Recently, epigenetics has pointed out that changes in methylation levels, histone modifications, and RNA editing could affect pancreatic differentiation and proliferation, leading to abnormal islet development and possibly induction of adult diabetes. Early interventions such as nutritional supplementation during pregnancy and exercise can prevent the onset of diabetes.

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备注/Memo

备注/Memo:
通信作者:袁庆新,Email:yqx@njmu.edu.cn
Corresponding author: Yuan Qingxin, Email: yqx@njmu.edu.cn
基金项目:国家自然科学基金(81570697)
Fund program:National Natural Science Foundation of China(81570697)
更新日期/Last Update: 2019-11-29