[1]黄莉吉,谢绍锋,刘超.肥胖相关性肾病的研究进展[J].国际内分泌代谢杂志,2015,(03):180-172.[doi:10.3760/cma.j.issn.1673-4157.2015.03.010]
　Huang Liji*,Xie Shaofeng,Liu Chao..Obesity-related glomerulopathy[J].International Journal of Endocrinology and Metabolism,2015,(03):180-172.[doi:10.3760/cma.j.issn.1673-4157.2015.03.010]
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肥胖相关性肾病的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
180-172
栏目:
肾脏疾病专栏
出版日期:
2015-05-20

文章信息/Info

Title:
Obesity-related glomerulopathy
作者:
黄莉吉; 谢绍锋; 刘超
210029　南京中医药大学附属医院内分泌科（黄莉吉）；210028　南京中医药大学附属中西医结合医院内分泌科（谢绍锋，刘超） 　　
Author(s):
Huang Liji*; Xie Shaofeng; Liu Chao.
*Department of Endocrinology， Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，China Corresponding author：Xie Shaofeng，Email：xiesf3562@sina.com
关键词:
肥胖相关性肾病; 肥胖; 慢性肾脏疾病
Keywords:
Obesity-related glomerulopathy; Obesity; Chronic kidney diseases
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.010
摘要:
随着肥胖成为流行性疾病，肥胖相关性肾病（ORG）的发生率明显升高。ORG的发生与胰岛素抵抗、高瘦素血症、脂代谢异常、肾素-血管紧张素-醛固酮系统（RAAS）激活和氧化应激等因素密切相关。生活方式改变、减轻体重、使用改善胰岛素抵抗药物、抑制RAAS活性药物以及选择性抗炎药物等有助于延缓ORG进展。
Abstract:
With the epidemic of obesity，the incidence of obesity-related glomerulopathy（ORG） has increased significantly. The pathogenetic mechanisms of ORG include：insulin resistance，hyperleptinemia， lipid metabolic disorders，activation of renin angiotensin aldosterone system（RAAS），oxidative stress and so on. Lifestyle modification，weight loss，drug therapy of insulin resistance，RAAS blockade and selective anti-inflammatory drugs may be beneficial to ameliorate the progression of ORG.

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备注/Memo

备注/Memo:
基金项目：江苏省自然科学基金项目（BK2011867）；江苏省中医药局科技项目（LZ11047） 通信作者：谢绍锋，Email：xiesf3562@sina.com
更新日期/Last Update: 2015-05-20