[1]刘美娟,朱惠娟,龚凤英.Glypican-,4与肥胖及胰岛素抵抗[J].国际内分泌代谢杂志,2015,(03):183-186.[doi:10.3760/cma.j.issn.1673-4157.2015.03.011]
 Liu Meijuan,Zhu Huijuan,Gong Fengying..Glypican-4 and obesity,insulin resistance[J].International Journal of Endocrinology and Metabolism,2015,(03):183-186.[doi:10.3760/cma.j.issn.1673-4157.2015.03.011]
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Glypican-,4与肥胖及胰岛素抵抗()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
期数:
2015年03
页码:
183-186
栏目:
综述
出版日期:
2015-05-20

文章信息/Info

Title:
Glypican-4 and obesity,insulin resistance
作者:
刘美娟朱惠娟龚凤英
100730 北京,中国医学科学院,中国协和医科大学,北京协和医院内分泌科,卫生部内分泌重点实验室,协和转化医学中心   
Author(s):
Liu MeijuanZhu HuijuanGong Fengying.
Department of Endocrinology,Key Laboratory of Endocrinology of Ministry of Health,The Translational Medicine Center of PUMCH,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China Corresponding author:Gong Fengying,Email:fygong@sina.com
关键词:
Glypican-4脂肪细胞因子脂肪组织肥胖胰岛素抵抗
Keywords:
Glypican-4AdipokineAdipose tissueObesityInsulin resistance
DOI:
10.3760/cma.j.issn.1673-4157.2015.03.011
摘要:
Glypican-4是一种新的脂肪细胞因子,其在皮下和内脏脂肪组织中差异表达,并与体重指数、腰臀比密切相关。Glypican-4通过直接与胰岛素受体结合,发挥类似胰岛素的作用,促进葡萄糖的摄取和前脂肪细胞的分化。在肥胖和糖尿病等具有胰岛素抵抗的患者中,glypican-4可通过代偿性分泌增加,维持机体血糖水平正常。Glypican-4是第一个被发现能直接与胰岛素受体结合,发挥增强胰岛素信号转导作用的脂肪细胞因子。研究其在胰岛素信号转导方面的功能将可能为肥胖和糖尿病的诊治带来新的契机。
Abstract:
Glypican-4 serving as a novel adipokine is differentially expressed in visceral and subcutaneous adipose tissue,and its expression is also highly correlated with body mass index and waist-to-hip ratio. Glypican-4 interacts with insulin receptor,exerts the similar role as insulin and promotes glucose uptake and adipocyte differentiation. The increase of the compensatory glypican-4 secretion is observed in obese and diabetic patients with insulin resistance,which can help to maintain normal blood glucose. Glypican-4 is the first adipose-derived insulin sensitizer which acts directly on the insulin receptor to enhance insulin signaling. Further study of the function of glypican-4 in insulin signaling may bring new opportunity for the diagnosis and treatment of obesity and diabetes.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(30540036,30771026, 81370898);北京市自然科学基金资助项目(7082079);人社部留学人员科技活动项目择优资助经费;国家临床重点专科建设项目单位(WBYZ2011-873) 通信作者:龚凤英,Email: fygong@sina.com.
更新日期/Last Update: 2015-05-20