[1]相萍萍 韦晓 刘超.新型冠状病毒肺炎与糖尿病:我们何去何从?[J].国际内分泌代谢杂志,2022,42(01):50-53.[doi:10.3760/cma.j.cn121383-20201116-11033]
 Xiang Pingping,Wei Xiao,Liu Chao..New coronavirus pneumonia and diabetes: Where shall we go?[J].International Journal of Endocrinology and Metabolism,2022,42(01):50-53.[doi:10.3760/cma.j.cn121383-20201116-11033]
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新型冠状病毒肺炎与糖尿病:我们何去何从?()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年01期
页码:
50-53
栏目:
综述
出版日期:
2022-01-20

文章信息/Info

Title:
New coronavirus pneumonia and diabetes: Where shall we go?
作者:
相萍萍 韦晓 刘超
南京中医药大学附属中西医结合医院,江苏省中医药研究院 210028
Author(s):
Xiang Pingping Wei Xiao Liu Chao.
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China
关键词:
新型冠状病毒肺炎 糖尿病 严重急性呼吸综合征病毒2 血管紧张素转化酶2
Keywords:
COVID-19 Diabetes SARS-COV-2 ACE2
DOI:
10.3760/cma.j.cn121383-20201116-11033
摘要:
新型冠状病毒肺炎(简称新冠肺炎,又称COVID-19)是危害全球的流行性疾病,其与糖尿病的关系研究甚少。糖尿病是新冠肺炎最常见的并发症之一,糖尿病患者免疫功能障碍、促炎性细胞因子环境、血管紧张素转换酶2表达降低及低血糖反应等与新冠肺炎的不良预后密切相关。而严重急性呼吸综合征病毒2(SARS-CoV-2)直接损伤胰岛β细胞、加剧胰岛素抵抗、诱发糖尿病酮症酸中毒、引起低钾血症等均加重糖尿病患者血糖异常。总之,新冠肺炎加重血糖异常,血糖异常又恶化新冠肺炎的病情,新冠肺炎与糖尿病的双向作用形成了恶性循环。故需采取有效的预防、治疗措施,确保控制糖尿病患者的血糖水平。
Abstract:
New coronavirus pneumonia(or coronavirus disease 2019, COVID-19)is an epidemic disease that endanger the world. The relationship between COVID-19 and diabetes has been poorly studied. Diabetes is one of the most common complications of COVID-19. Diabetic patients' immune dysfunction, pro-inflammatory cytokine environment, reduced expression of angiotensin-converting enzyme 2 and hypoglycemia are closely related to the poor prognosis of COVID-19. Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)directly damages pancreatic islet β cells, aggravates insulin resistance, induces diabetic ketoacidosis, and causes hypokalemia, all of which aggravate the blood sugar in diabetic patients. In short, the two-way interaction between COVID-19 and diabetes mellitus sets up a vicious cycle wherein COVID-19 leads to worsening of dysglycemia and diabetes mellitus, which in turn exacerbates the severity of COVID-19. Therefore, it is imperative that people with diabetes mellitus need to take effective preventive and therapeutic measures to ensure that the blood sugar level is well controlled.

参考文献/References:

[1] World Health Organization.WHO Coronavirus disease(COVID-2019)Dashboard[EB/OL].(2021-12-09)[2021-12-09].https://covid19.who.int.
[2] Guan WJ,Ni ZY,Hu Y,et al.Clinical Characteristics of Coronavirus Disease 2019 in China[J].N Engl J Med,2020,382(18):1708-1720.DOI:10.1056/NEJMoa2002032.
[3] Wu H,Lau ESH,Ma RCW,et al.Secular trends in all-cause and cause-specific mortality rates in people with diabetes in Hong Kong,2001-2016:a retrospective cohort study[J].Diabetologia,2020,63(4):757-766.DOI:10.1007/s00125-019-05074-7.
[4] Allard R,Leclerc P,Tremblay C,et al.Diabetes and the severity of pandemic influenza A(H1N1)infection[J].Diabetes Care,2010,33(7):1491-1493.DOI:10.2337/dc09-2215.
[5] Yang JK,Feng Y,Yuan MY,et al.Plasma glucose levels and diabetes are independent predictors for mortality and morbidity in patients with SARS[J].Diabet Med,2006,23(6):623-628.DOI:10.1111/j.1464-5491.2006.01861.x.
[6] Fadini GP,Morieri ML,Longato E,et al.Prevalence and impact of diabetes among people infected with SARS-CoV-2[J].J Endocrinol Invest,2020,43(6):867-869.DOI:10.1007/s40618-020-01236-2.
[7] Li Y,Teng D,Shi X,et al.Prevalence of diabetes recorded in mainland China using 2018 diagnostic criteria from the American Diabetes Association:national cross sectional study[J].BMJ,2020,369:m997.DOI:10.1136/bmj.m997.
[8] Longato E,Di Camillo B,Sparacino G,et al.Diabetes diagnosis from administrative claims and estimation of the true prevalence of diabetes among 4.2 million individuals of the Veneto region(North East Italy)[J].Nutr Metab Cardiovasc Dis,2020,30(1):84-91.DOI:10.1016/j.numecd.2019.08.017.
[9] Frydrych LM,Bian G,O'Lone DE,et al.Obesity and type 2 diabetes mellitus drive immune dysfunction,infection development,and sepsis mortality[J].J Leukoc Biol,2018,104(3):525-534.DOI:10.1002/JLB.5VMR0118-021RR.
[10] Knapp S.Diabetes and infection:is there a link--A mini-review[J].Gerontology,2013,59(2):99-104.DOI:10.1159/000345107.
[11] Guo W,Li M,Dong Y,et al.Diabetes is a risk factor for the progression and prognosis of COVID-19[J].Diabetes Metab Res Rev,2020,e3319.DOI:10.1002/dmrr.3319.
[12] Pal R,Bhadada SK.COVID-19 and diabetes mellitus:An unholy interaction of two pandemics[J].Diabetes Metab Syndr,2020,14(4):513-517.DOI:10.1016/j.dsx.2020.04.049.
[13] Letko M,Marzi A,Munster V.Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses[J].Nat Microbiol,2020,5(4):562-569.DOI:10.1038/s41564-020-0688-y.
[14] Imai Y,Kuba K,Rao S,et al.Angiotensin-converting enzyme 2 protects from severe acute lung failure[J].Nature,2005,436(7047):112-116.DOI:10.1038/nature03712.
[15] Zhou J,Tan J.Diabetes patients with COVID-19 need better blood glucose management in Wuhan,China[J].Metabolism,2020,107:154216.DOI:10.1016/j.metabol.2020.154216.
[16] Ren H,Yang Y,Wang F,et al.Association of the insulin resistance marker TyG index with the severity and mortality of COVID-19[J].Cardiovasc Diabetol,2020,19(1):58.DOI:10.1186/s12933-020-01035-2.
[17] Li J,Wang X,Chen J,et al.COVID-19 infection may cause ketosis and ketoacidosis[J].Diabetes Obes Metab,22(10):1935-1941.DOI:10.1111/dom.14057.
[18] Bindom SM,Hans CP,Xia H,et al.Angiotensin I-converting enzyme type 2(ACE2)gene therapy improves glycemic control in diabetic mice[J].Diabetes,2010,59(10):2540-8.DOI:10.2337/db09-0782.
[19] Yang JK,Lin SS,Ji XJ,et al.Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes[J].Acta Diabetol,2010,47(3):193-9.DOI:10.1007/s00592-009-0109-4.
[20] Lyu J,Imachi H,Fukunaga K,et al.Angiotensin II induces cholesterol accumulation and impairs insulin secretion by regulating ABCA1 in beta cells[J].J Lipid Res,2018,59(10):1906-1915.DOI:10.1194/jlr.M085886.
[21] Szymczak-Pajor I,S'liwińska A.Analysis of association between Vitamin D deficiency and insulin resistance[J].Nutrients,2019,11(4):794.DOI:10.3390/nu11040794.
[22] Chen D,Li X,Song Q,et al.Assessment of hypokalemia and clinical characteristics in patients with coronavirus disease 2019 in Wenzhou,China[J].JAMA Netw Open,2020,3(6):e2011122.DOI:10.1001/jamanetworkopen.2020.11122.
[23] Rowe JW,Tobin JD,Rosa RM,et al.Effect of experimental potassium deficiency on glucose and insulin metabolism[J].Metabolism,1980,29(6):498-502.DOI:10.1016/0026-0495(80)90074-8.

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备注/Memo

备注/Memo:
通信作者:刘超,Email: liuchao@nfmcn.com
更新日期/Last Update: 2022-01-20