[1]杨曦,刘玉洁,马慧娟.γ-氨基丁酸与糖尿病[J].国际内分泌代谢杂志,2017,37(01):45-47.[doi:10.3760/cma.j.issn.1673-4157.2017.01.13]
 Yang Xi*,Liu Yujie,Ma Huijuan..γ-aminobutyric acid and diabetes[J].International Journal of Endocrinology and Metabolism,2017,37(01):45-47.[doi:10.3760/cma.j.issn.1673-4157.2017.01.13]
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γ-氨基丁酸与糖尿病()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年01期
页码:
45-47
栏目:
综述
出版日期:
2017-01-20

文章信息/Info

Title:
γ-aminobutyric acid and diabetes
作者:
杨曦刘玉洁马慧娟
050017 石家庄,河北医科大学研究生学院(杨曦,刘玉洁),内科学教研室(马慧娟); 050051 石家庄,河北省人民医院内分泌科(马慧娟)
Author(s):
Yang Xi* Liu Yujie Ma Huijuan.
*Graduate Institute of Hebei Medical University, Shijiazhuang 050017, China
关键词:
γ-氨基丁酸 糖尿病 γ-氨基丁酸受体
Keywords:
γ-aminobutyric acid Diabetes mellitus γ-aminobutyric acid receptor
DOI:
10.3760/cma.j.issn.1673-4157.2017.01.13
摘要:
γ-氨基丁酸(GABA)是中枢神经系统一种重要的抑制性神经递质,除神经元细胞外,胰岛β细胞也能大量合成GABA。GABA作为重要的胞外信号分子,可调节胰岛细胞的分泌和功能。在β细胞,GABA通过诱导细胞膜去极化,增加胰岛素分泌。在α细胞内,GABA则通过诱导细胞膜超极化,抑制胰高血糖素分泌。GABA通过双相调节发挥降糖作用,在糖尿病治疗中发挥重要作用。
Abstract:
γ-aminobutyric acid(GABA), a major inhibitory neurotransmitter, is not only produced by neurons, but also by islet β cells. As an important intraislet transmitter, GABA plays a key role in regulating islet cell secretion and function. In β cells, GABA increases insulin secretion through induction of cell membrane depolarization. However, in α cells,GABA suppresses glucagon secretion by inducing cell membrane hyperpolarization. GABA can reduce blood glucose by bipolar regulation, and play an important role in the treatment of diabetes.

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备注/Memo

备注/Memo:
通信作者:马慧娟, Email: huijuanma76@163.com
更新日期/Last Update: 2017-01-20