[1]于珊珊,杜建玲.硒蛋白S与糖尿病及大血管并发症[J].国际内分泌代谢杂志,2016,36(06):408-411,423.[doi:10.3760/cma.j.issn.1673-4157.2016.06.13]
 Yu Shanshan,Du Jianling..Relationship between selenoprotein S, diabetes and its macrovascular complications[J].International Journal of Endocrinology and Metabolism,2016,36(06):408-411,423.[doi:10.3760/cma.j.issn.1673-4157.2016.06.13]
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硒蛋白S与糖尿病及大血管并发症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年06期
页码:
408-411,423
栏目:
综述
出版日期:
2016-11-20

文章信息/Info

Title:
Relationship between selenoprotein S, diabetes and its macrovascular complications
作者:
于珊珊杜建玲
116011 大连医科大学附属第一医院内分泌科
Author(s):
Yu Shanshan Du Jianling.
Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, China
关键词:
硒蛋白S 糖尿病 大血管并发症 单核苷酸多态性
Keywords:
Selenoprotein S Diabetes mellitus Macrovascular complications Single nucleotide polymorphism
DOI:
10.3760/cma.j.issn.1673-4157.2016.06.13
摘要:
硒蛋白S为一种膜蛋白,其组织分布广泛,与炎性反应、氧化应激及内质网应激关系密切。研究发现,不同组织的硒蛋白S在糖尿病及其大血管并发症发生、发展中的作用不同。胰腺及血管中的硒蛋白S发挥抗氧化及抗内质网应激的保护效应,而肝脏、脂肪组织及骨骼肌中的硒蛋白S反而促进糖尿病及胰岛素抵抗的发生、发展。因此,全面地剖析硒蛋白S在各组织中的作用特点及机制,可为糖尿病及其大血管并发症提供新的防治策略。
Abstract:
Selenoprotein S is identified as a transmembrane protein and expressed in numberous tissues. It is closely related to inflammatory response, oxidative stress and endoplasmic reticulum stress. Selenoprotein S in different tissues has been suggested to play different roles in the pathogenesis and progression of diabetes and its macrovascular complications. Selenoprotein S in pancreatic and vascular exerts anti-oxidative and anti-endoplasmic reticulum stress capacity, while selenoprotein S in liver, adipose tissue and skeletal muscle can promote the pathogenesis and progression of diabetes and insulin resistance. Thus, analyzing the function and mechanism of selenoprotein S in various tissues comprehensively can provide new strategies for the prevetion and treatment of diabetes and its macrovascular diseases.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81570727,30970841)
更新日期/Last Update: 2016-12-20