[1]段晓晔,郭立新.2型糖尿病与胰腺癌关系的研究进展[J].国际内分泌代谢杂志,2022,42(06):473-476.[doi:10.3760/cma.j.cn121383-20210609-06014]
 Duan Xiaoye,Guo Lixin..Research progress of the relationship between type 2 diabetes mellitus and pancreatic cancer[J].International Journal of Endocrinology and Metabolism,2022,42(06):473-476.[doi:10.3760/cma.j.cn121383-20210609-06014]
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2型糖尿病与胰腺癌关系的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
42
期数:
2022年06期
页码:
473-476
栏目:
综述
出版日期:
2022-11-20

文章信息/Info

Title:
Research progress of the relationship between type 2 diabetes mellitus and pancreatic cancer
作者:
段晓晔12郭立新12
1北京医院内分泌科 国家老年医学中心 100010; 2北京协和医学院研究生院 100005
Author(s):
Duan Xiaoye12 Guo Lixin12.
1Department of Endocrinology, Beijing Hospital, National Center of Gerontology, Beijing 100010, China; 2Graduate School of Peking Union Medical College, Beijing 100005, China
关键词:
2型糖尿病 胰腺癌 早期诊断 降糖治疗
Keywords:
Type 2 diabetes mellitus Pancreatic cancer Early diagnosis Antidiabetic drug
DOI:
10.3760/cma.j.cn121383-20210609-06014
摘要:
2型糖尿病与胰腺癌的发生、发展关系密切而复杂。联合危险因素和生物标志物在新发糖尿病患者中进行筛选,有望成为早期检测胰腺癌并改善其预后的线索。常用降糖药二甲双胍对降低胰腺癌的风险明确有益,新型降糖药与胰腺癌的发病风险也逐渐被关注,两者的相关性还需要更多样本量大、随访周期长的随机对照研究证实。本综述讨论了糖尿病与胰腺癌发生的相关机制,总结糖尿病人群发生胰腺癌的危险因素和早期生物标志物,并对其防治策略进行探索。
Abstract:
The relationship between type 2 diabetes mellitus and pancreatic cancer is very close, but the complex mechanism remains unclear. Screening combined risk factors and early biomarkers in patients with new-onset diabetes is expected to be a very important clue for early detection of pancreatic cancer and significant improvement in prognosis of pancreatic cancer. Metformin, as a common hypoglycemic drug, is clearly beneficial in reducing the risk of pancreatic cancer. In recent years, the association between the novel oral hypoglycemic drugs and risk of pancreatic cancer has been increasingly concerned. More high-quality and quantity randomized controlled trials with a large sample size and long duration time are very necessary in the future. In this review, we discuss the mechanism of type 2 diabetes mellitus and pancreatic cancer, summarize the risk factors and early biomarkers of pancreatic cancer in patients with type 2 diabetes mellitus, and explore prevention and treatment strategies.

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备注/Memo

备注/Memo:
通信作者:郭立新,Email:glx1218@163.com
基金项目:国家自然科学基金面上项目(8217033642)
更新日期/Last Update: 2022-12-01