参考文献/References:
[1] Müller TD,Finan B,Bloom SR,et al.Glucagon-like peptide 1(GLP-1)[J].Mol Metab,2019,30:72-130.DOI:10.1016/j.molmet.2019.09.010.
[2] El K,Campbell JE.The role of GIP in α-cells and glucagon secretion[J].Peptides,2020,125:170213.DOI:10.1016/j.peptides.2019.170213.
[3] Bailey CJ.GIP analogues and the treatment of obesity-diabetes[J].Peptides,2020,125:170202.DOI:10.1016/j.peptides.2019.170202.
[4] Min T,Bain SC.The Role of Tirzepatide,Dual GIP and GLP-1 receptor agonist,in the management of type 2 diabetes:the SURPASS clinical trials[J].Diabetes Ther,2021,12(1):143-157.DOI:10.1007/s13300-020-00981-0.
[5] Ludvik B,Giorgino F,Jódar E,et al.Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes(SURPASS-3):a randomised,open-label,parallel-group,phase 3 trial[J].Lancet,2021,398(10300):583-598.DOI:10.1016/S0140-6736(21)01443-4.
[6] Urva S,Quinlan T,Landry J,et al.Effects of renal impairment on the pharmacokinetics of the dual GIP and GLP-1 receptor agonist tirzepatide[J].Clin Pharmacokinet,2021,60(8):1049-1059.DOI:10.1007/s40262-021-01012-2.
[7] Janah L,Kjeldsen S,Galsgaard KD,et al.Glucagon receptor signaling and glucagon resistance[J].Int J Mol Sci,2019,20(13):3314.DOI:10.3390/ijms20133314.
[8] Kosinski JR,Hubert J,Carrington PE,et al.The glucagon receptor is involved in mediating the body weight-lowering effects of oxyntomodulin[J].Obesity(Silver Spring),2012,20(8):1566-1571.DOI:10.1038/oby.2012.67.
[9] Ambery P,Parker VE,Stumvoll M,et al.MEDI0382,a GLP-1 and glucagon receptor dual agonist,in obese or overweight patients with type 2 diabetes:a randomised,controlled,double-blind,ascending dose and phase 2a study[J].Lancet,2018,391(10140):2607-2618.DOI:10.1016/S0140-6736(18)30726-8.
[10] Nahra R,Wang T,Gadde KM,et al.Effects of cotadutide on metabolic and hepatic parameters in adults with overweight or obesity and type 2 diabetes:a 54-week randomized phase 2b study[J].Diabetes Care,2021,44(6):1433-1442.DOI:10.2337/dc20-2151.
[11] Schiavon M,Visentin R,Göbel B,et al.Improved postprandial glucose metabolism in type 2 diabetes by the dual glucagon-like peptide-1/glucagon receptor agonist SAR425899 in comparison with liraglutide[J].Diabetes Obes Metab,2021,23(8):1795-1805.DOI:10.1111/dom.14394.
[12] Pathak V,Flatt PR,Irwin N.Cholecystokinin(CCK)and related adjunct peptide therapies for the treatment of obesity and type 2 diabetes[J].Peptides,2018,100:229-235.DOI:10.1016/j.peptides.2017.09.007.
[13] Hornigold DC,Roth E,Howard V,et al.A GLP-1:CCK fusion peptide harnesses the synergistic effects on metabolism of CCK-1 and GLP-1 receptor agonism in mice[J].Appetite,2018,127:334-340.DOI:10.1016/j.appet.2018.05.131.
[14] Gault VA,Bhat VK,Irwin N,et al.A novel glucagon-like peptide-1(GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide,GLP-1,and glucagon receptors and therapeutic potential in high fat-fed mice[J].J Biol Chem,2013,288(49):35581-35591.DOI:10.1074/jbc.M113.512046.
[15] Cui J,Shang A,Wang W,et al.Rational design of a GLP-1/GIP/Gcg receptor triagonist to correct hyperglycemia,obesity and diabetic nephropathy in rodent animals[J].Life Sci,2020,260:118339.DOI:10.1016/j.lfs.2020.118339.
[16] Willard FS,Douros JD,Gabe MB,et al.Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist[J].JCI Insight,2020,5(17):e140532.DOI:10.1172/jci.insight.140532.
[17] Henderson SJ,Konkar A,Hornigold DC,et al.Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates[J].Diabetes Obes Metab,2016,18(12):1176-1190.DOI:10.1111/dom.12735.
[18] Hartman ML,Sanyal AJ,Loomba R,et al.Effects of novel dual GIP and GLP-1 receptor agonist tirzepatide on biomarkers of nonalcoholic steatohepatitis in patients with type 2 diabetes[J].Diabetes Care,2020,43(6):1352-1355.DOI:10.2337/dc19-1892.
[19] Kannt A,Madsen AN,Kammermeier C,et al.Incretin combination therapy for the treatment of non-alcoholic steatohepatitis[J].Diabetes Obes Metab,2020,22(8):1328-1338.DOI:10.1111/dom.14035.
[20] Gupta NA,Mells J,Dunham RM,et al.Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway[J].Hepatology,2010,51(5):1584-1592.DOI:10.1002/hep.23569.
[21] Hölscher C.Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models[J].Neuropharmacology,2018,136(Pt B):251-259.DOI:10.1016/j.neuropharm.2018.01.040.
[22] 焦娟娟,Christian Hölscher,李甜,等.GLP-1/GIP/Gcg三受体激动剂改善阿尔茨海默病三转基因小鼠的认知行为[J].生理学报,2017,69(2):135-145.DOI:10.13294/j.aps.2017.0005.
[23] Wilson JM,Nikooienejad A,Robins DA,et al.The dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist,tirzepatide,improves lipoprotein biomarkers associated with insulin resistance and cardiovascular risk in patients with type 2 diabetes[J].Diabetes Obes Metab,2020,22(12):2451-2459.DOI:10.1111/dom.14174.
[24] Harada T,Obokata M.Obesity-related heart failure with preserved ejection fraction:pathophysiology,diagnosis,and potential therapies[J].Heart Fail Clin,2020,16(3):357-368.DOI:10.1016/j.hfc.2020.02.004.