[1]乔冠华,李强.胰高血糖素样肽-1受体激动剂治疗多囊卵巢综合征的研究进展[J].国际内分泌代谢杂志,2017,37(03):181-185.[doi:10.3760/cma.j.issn.1673-4157.2017.03.010]
 Qiao Guanhua,Li Qiang..Glucagon like peptide-1 receptor agonist in the treatment of polycystic ovary syndrome[J].International Journal of Endocrinology and Metabolism,2017,37(03):181-185.[doi:10.3760/cma.j.issn.1673-4157.2017.03.010]
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胰高血糖素样肽-1受体激动剂治疗多囊卵巢综合征的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年03期
页码:
181-185
栏目:
综述
出版日期:
2017-05-20

文章信息/Info

Title:
Glucagon like peptide-1 receptor agonist in the treatment of polycystic ovary syndrome
作者:
乔冠华李强
150086 哈尔滨医科大学附属第二医院内分泌代谢病科
Author(s):
Qiao Guanhua Li Qiang.
Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China
关键词:
多囊卵巢综合征 胰高血糖素样肽-1受体激动剂 胰岛素抵抗 体重 性激素
Keywords:
Polycystic ovary syndrome Glucagon-like peptide-1 receptor agonist Insulin resistance Weight Sex hormones
DOI:
10.3760/cma.j.issn.1673-4157.2017.03.010
摘要:
多囊卵巢综合征(PCOS)是育龄期女性常见的一类内分泌紊乱疾病,可导致不孕。目前其病因尚未完全明确。高雄激素血症、胰岛素抵抗(IR)及高胰岛素血症等内分泌激素紊乱是其重要特征。现已证实,胰高血糖素样肽-1受体激动剂(GLP-1Ra)能够改善PCOS患者IR,减轻体重,并能影响其睾酮、黄体生成素、卵泡刺激素的分泌,因而可能干预PCOS的发生、发展。与此同时,GLP-1Ra还能对PCOS伴发2型糖尿病、心血管系统疾病、非酒精性脂肪性肝病发挥作用。
Abstract:
Polycystic ovary syndrome(PCOS)is one of the common endocrine disorders in reproductive-aged women, which is associated with a serious consequence to infertility. The etiology is not yet clear at present. Hyperandrogenism, insulin resistance(IR)and hyperinsulinemia and other endocrine hormone disorders are the most important characteristics. It has been showed that glucagon-like peptide-1 receptor agonist(GLP-1Ra)can improve IR, lose weight, and have effects on the secretion of testosterone, luteinizing hormone and follicle stimulating hormone,and thus likely to make it possible that GLP-1Ra be used to interfere with the occurrence and development of PCOS. At the same time, GLP-1Ra can also play a role in the development of PCOS associated with type 2 diabetes, cardiovascular disease, and nonalcoholic fatty liver disease.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81170744,813709027) 通信作者:李强,Email:QiangLi26@126.com
更新日期/Last Update: 2017-05-20