[1]张亚迪 张晓梅 孙卫华.缺血修饰清蛋白与糖尿病及其并发症[J].国际内分泌代谢杂志,2019,39(05):341-344.[doi:10.3760/cma.j.issn.1673-4157.2019.05.013]
 Zhang Yadi,Zhang Xiaomei,Sun Weihua.Ischemia modified albumin, diabetes and its complications[J].International Journal of Endocrinology and Metabolism,2019,39(05):341-344.[doi:10.3760/cma.j.issn.1673-4157.2019.05.013]
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缺血修饰清蛋白与糖尿病及其并发症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年05期
页码:
341-344
栏目:
综述
出版日期:
2019-09-20

文章信息/Info

Title:
Ischemia modified albumin, diabetes and its complications
作者:
张亚迪 张晓梅 孙卫华
蚌埠医学院第一附属医院内分泌科 233000
Author(s):
Zhang Yadi Zhang Xiaomei Sun Weihua
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
关键词:
缺血修饰清蛋白 糖尿病 糖尿病并发症
Keywords:
Ischemia modified albumin Diabetes mellitus Diabetic complication
DOI:
10.3760/cma.j.issn.1673-4157.2019.05.013
摘要:
缺血修饰清蛋白(IMA)是一种因缺血而被修饰的人血清白蛋白。IMA不仅仅在心肌缺血中会升高,在许多其他缺血性疾病中也会升高,所以近年来IMA被视为一种缺血标志物。在糖尿病患者中,IMA与HbA1c呈正相关,但也有研究者认为在糖尿病未合并血管并发症时,IMA水平不会受到血糖水平的影响。由于血糖控制不良引起的糖尿病并发症有潜在的缺血性病因学,故IMA在糖尿病大血管病变、糖尿病微血管病变中均呈升高趋势,并与病变程度密切相关,故定期监测IMA水平可能对糖尿病并发症的早期预防、早期诊断以及治疗有重要意义。
Abstract:
Ischemic modified albumin(IMA)is a human serum albumin modified by ischemia. Studies have found that IMA can be elevated not only in myocardial ischemia, but also in many other ischemic diseases. Therefore, in recent years, IMA has been regarded as an ischemic marker. IMA is positively correlated with HbA1c in diabetic patients, but some researchers believe that IMA level is not affected by blood glucose level in diabetic patients without vascular complications. Due to the potential ischemic etiology of diabetic complications caused by poor glycemic control, IMA shows an increasing trend in diabetic macrovascular disease and diabetic microvascular disease and is closely related to the severity of the disease. Therefore, regular monitoring of IMA level may be of great significance for the prevention, diagnosis and treatment of diabetic complications.

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备注/Memo

备注/Memo:
通信作者:孙卫华,Email: sunwh2007@163.com
Corresponding author: Sun Weihua, Email:sunwh2007@163.com
更新日期/Last Update: 2019-09-20