[1]周梦云 胡小磊 张晓梅.Semaphorin3A及其受体与糖尿病血管并发症的关系[J].国际内分泌代谢杂志,2018,38(01):55-58.[doi:10.3760/cma.j.issn.1673-4157.2018.01.015]
 Zhou Mengyun,Hu Xiaolei,Zhang Xiaomei.Relationship between Semaphorin3A,its receptors and diabetic vascular complications[J].International Journal of Endocrinology and Metabolism,2018,38(01):55-58.[doi:10.3760/cma.j.issn.1673-4157.2018.01.015]
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Semaphorin3A及其受体与糖尿病血管并发症的关系()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
38
期数:
2018年01期
页码:
55-58
栏目:
综述
出版日期:
2018-01-20

文章信息/Info

Title:
Relationship between Semaphorin3A,its receptors and diabetic vascular complications
作者:
周梦云 胡小磊 张晓梅
233000 蚌埠医学院第一附属医院内分泌科
Author(s):
Zhou Mengyun Hu Xiaolei Zhang Xiaomei
Department of Endocrinology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China
关键词:
Semaphorin3A 糖尿病 血管并发症
Keywords:
Semaphorin3A Diabetes mellitus Vascular complications
DOI:
10.3760/cma.j.issn.1673-4157.2018.01.015
摘要:
Semaphorin3A是最初在神经系统中发现的分泌型糖蛋白。它有两个受体:Nrp和Plexin。Nrp为非酪氨酸激酶跨膜糖蛋白, Plexin为单通道跨膜蛋白家族成员。近年来发现,Semaphorin3A及其受体可介导内皮细胞受损,与糖尿病肾病、糖尿病视网膜病变、糖尿病神经病变等并发症密切相关,促进糖尿病血管并发症的发生与发展。对Semaphorin3A更深入的研究,将为糖尿病血管并发症的早期诊断、监测和治疗开辟新的途径。
Abstract:
Semaphorin3A is a secretory glycoprotein originally found in the nervous system. Its has two receptors:Nrp and Plexin. Nrp is a non-tyrosine kinase transmembrane glycoprotein and Plexin is a member of single-channel transmembrane protein family. In recent years, it has been found that Semaphorin3A and its receptors can mediate the damage of endothelial cells and are closely related to the complications such as diabetic nephropathy, diabetic retinopathy and diabetic neuropathy, and promote the occurrence and development of diabetic vascular complications. Along with more and more researches of Semaphorin3A,new pathways for early diagnosis, monitor and intervention of diabetic vascular disease would be found.

参考文献/References:


[1] Kwon SH,Shin JP,Kim IT,et al.Association of plasma semaphorin 3A with phenotypes of diabetic retinopathy and nephropathy[J].Invest Ophthalmol Vis Sci,2016,57(7):2983-2989.DOI:10.1167/iovs.16-19468.
[2] Rezaeepoor M,Shapoori S,Ganjalikhani-Hakemi M,et al. Decreased expression of Sema3A, an immune modulator, in blood sample of multiple sclerosis patients[J].Gene,2017,610:59-63.DOI:10.1016/j.gene.2017.02.013.
[3] Noguchi K,Ishikawa R,Kawaguchi M,et al.Expression patterns of Sema3A in developing amniote limbs: with reference to the diversification of peripheral nerve innervation[J].Dev Growth Differ,2017,59(4):270-285.DOI:10.1111/dgd.12364.
[4] Ma R,Wang L,Zhao B,et al.Diabetes perturbs bone microarchitecture and bone strength through regulation of Sema3A/IGF-1/β-catenin in rats[J].Cell Physiol Biochem,2017,41(1):55-66.DOI:10.1159/000455936.
[5] Zhao C,Liu J,Zhang M,et al.Semaphorin 3A deficiency improves hypoxia-induced myocardial injury via resisting inflammation and cardiomyocytes apoptosis[J].Cell Mol Biol(Noisy-le-grand),2016,62(2):8-14.
[6] Merte J,Wang Q,Vander Kooi CW,et al.A forward genetic screen in mice identifies Sema3A(K108N), which binds to neuropilin-1 but cannot signal[J].J Neurosci,2010, 30(16):5767-5775.DOI:10.1523/JNEUROSCI.5061-09.2010.
[7] Nogi T,Yasui N,Mihara E,et al. Structural basis for semaphorin signalling through the plexin receptor[J].Nature,2010,467(7319):1123-1127.DOI:10.1038/nature09473.
[8] Kigel B,Rabinowicz N,Varshavsky A,et al.Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling[J].Blood,2011,118(15):4285-4296.DOI:10.1182/blood-2011-03-341388.
[9] Reidy KJ,Aggarwal PK,Jimenez JJ,et al. Excess podocyte semaphorin-3A leads to glomerular disease involving plexinA1-nephrin interaction[J].Am J Pathol,2013,183(4):1156-1168.DOI:10.1016/j.ajpath.2013.06.022.
[10] Aggarwal PK,Veron D,Thomas DB,et al.Semaphorin3a promotes advanced diabetic nephropathy[J].Diabetes,2015,64(5):1743-1759.DOI:10.2337/db14-0719.
[11] Veron D,Bertuccio CA,Marlier A,et al.Podocyte vascular endothelial growth factor(Vegf164)overexpression causes severe nodular glomerulosclerosis in a mouse model of type 1 diabetes[J].Diabetologia,2011,54(5):1227-1241.DOI:10.1007/s00125-010-2034-z.
[12] Rodriguez F,Lopez B,Perez C,et al. Chronic tempol treatment attenuates the renal hemodynamic effects induced by a hemeoxygenase inhibitor in streptozotocin diabetic rats[J].Am J Physiol Regul Integr Comp Physiol,2011,301(5):R1540-R1548.DOI:10.1152/ajpregu.00847.2010.
[13] Saad S,Dharmapatni AASSK,Crotti TN,et al.Semaphorin-3a, neuropilin-1 and plexin-A1 in prosthetic-particle induced bone loss[J].Acta Biomater,2016,30:311-318.DOI:10.1016/j.actbio.2015.11.025.
[14] Sakai T,Takahashi D,Nikaido K,et al.Co-stimulation with interleukin-4 and tumor necrosis factor-α increases epidermalinnervation accompanied by suppression of semaphorin 3A[J].J Dermatol Sci,2014,76(1):69-71.DOI:10.1016/j.jdermsci.2014.06.005.
[15] 阳石坤,肖力,刘伏友,等.cAMP-Epac-Rap1信号通路在肾脏疾病中的研究进展 [J]. 中华肾脏病杂志,2012,28(6): 498-501. DOI:10.3760/cma.j.issn.1001-7097.2012.06.018.
[16] Cheema HR,Al Habash A,Al-Askar E.Improvement of visual acuity based on optical coherence tomography patterns following intravitreal bevacizumab treatment in patients with diabetic macular edema[J].Int J Ophthalmol,2014,7(2):251-255.DOI:10.3980/j.issn.2222-3959.2014.02.11.
[17] Wang J,Wang S,Li M,et al.The neuropilin-1 inhibitor, ATWLPPR peptide, prevents experimental diabetes-induced retinal Injury by preserving vascular integrity and decreasing oxidative stress[J].PLoS One,2015,10(11):e0142571.DOI:10.1371/journal.pone.0142571.
[18] Groppa E,Brkic S,Bovo E,et al..VEGF dose regulates vascular stabilization through Semaphorin3A and the Neuropilin-1+ monocyte/TGF-β1 paracrine axis[J].EMBO Mol Med,2015,7(10):1366-1384.DOI:10.15252/emmm.201405003.
[19] Acevedo LM,Barillas S,Weis SM,et al.Semaphorin 3A suppresses VEGF-mediated angiogenesis yet acts as a vascular permeability factor[J].Blood,2008,111(5):2674-2680.DOI:10.1182/blood-2007-08-110205.
[20] Hou ST, Nilchi L, Li X,et al.Semaphorin3A elevates vascular permeability and contributes to cerebral ischemia-induced brain damage[J].Sci Rep,2015,5:7890. DOI:10.1038/srep07890. DOI:10.1038/srep07890.
[21] Cerani A,Tetreault N,Menard C,et al.Neuron-derived semaphorin 3A is an early inducer of vascular permeability in diabetic retinopathy via neuropilin-1[J].Cell Metab,2013,18(4):505-518. DOI:10.1016/j.cmet.2013.09.003.
[22] Li G,Veenstra AA,Talahalli RR,et al.Marrow-derived cells regulate the development of early diabetic retinopathy and tactile allodynia in mice[J].Diabetes,2012,61(12):3294-3303.DOI:10.2337/db11-1249.
[23] Huang X,Sun M,Li D,et al.Augmented NADPH oxidase activity and p22phox expression in monocytes underlie oxidative stress of patients with type 2 diabetes mellitus[J].Diabetes Res Clin Pract,2011,91(3):371-380.DOI:10.1016/j.diabres.2010.12.026.
[24] Tanaka J,Tanaka H,Mizuki N,et al.Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis[J].Int J Ophthalmol,2015,8(1):1-10. DOI:10.3980/j.issn.2222-3959.2015.01.01.
[25] Ang L,Jaiswal M,Martin C,et al.Glucose control and diabetic neuropathy: lessons from recent large clinical trials[J].Curr Diab Rep,2014,14(9):528.DOI:10.1007/s11892-014-0528-7.
[26] Pop-Busui R,Ang L,Holmes C,et al.Inflammation as a therapeutic target for diabetic neuropathies[J].Curr Diab Rep,2016,16(3):29.DOI:10.1007/s11892-016-0727-5.

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备注/Memo

备注/Memo:
基金项目:安徽省卫生计生委科研计划项目(2016QK021); 安徽省自然科学基金(1508085SQH220)
通信作者:张晓梅,Email: zxm87517@163.com
更新日期/Last Update: 2018-01-30