[1]邓雪凤,曹雪亭,杨萍,等.慢性低度炎性反应与糖尿病肾脏疾病的 相关性分析:一项大样本病例-对照研究[J].国际内分泌代谢杂志,2017,37(06):373-375，380.
　Deng Xuefeng,Cao Xueting,Yang Ping,et al.Relationship between chronic low-grade inflammation and diabetic kidney disease: a large case-control study[J].International Journal of Endocrinology and Metabolism,2017,37(06):373-375，380.
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慢性低度炎性反应与糖尿病肾脏疾病的 相关性分析:一项大样本病例-对照研究()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年06期
页码:
373-375，380
栏目:
论著
出版日期:
2017-11-20

文章信息/Info

Title:
Relationship between chronic low-grade inflammation and diabetic kidney disease: a large case-control study
作者:
邓雪凤; 曹雪亭; 杨萍; 王越; 胡金波; 杨淑敏; 李启富
400016 重庆医科大学附属第一医院内分泌科
Author(s):
Deng Xuefeng;  Cao Xueting;  Yang Ping;  Wang Yue;  Hu Jinbo;  Yang Shumin;  Li Qifu.
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
关键词:
慢性低度炎症;  糖尿病;  糖尿病肾脏疾病
Keywords:
Chronic low-grade inflammation;  Diabetes mellitus;  Diabetic kidney disease
文献标志码:
A
摘要:
目的 探讨慢性低度炎性反应与糖尿病肾脏疾病(DKD)的关系。方法 将 1 254例2型糖尿病患者分为DKD组(487例)与单纯T2DM组(767例),DKD诊断依据:符合估算的肾小球滤过率(eGFR)<60 ml/(min·1.73 m2)或尿微量白蛋白/肌酐比值(UACR)≥30 mg/g。通过自动分析仪测定血清慢性低度炎性反应指标:超敏C反应蛋白(hs-CRP)、白细胞总数、中性粒细胞百分比(NCR),并记录性别、病程、收缩压、舒张压等指标。利用多元Logistic回归分析慢性低度炎性反应指标与DKD的关系。结果 与单纯T2DM组相比,DKD组的hs-CRP、白细胞总数、NCR均显著升高(t=-3.60、-3.43、3.10, P均<0.01)。多元Logistic回归分析显示,hs-CRP(OR=1.116, 95% CI: 1.042～1.195, P=0.002)、白细胞总数(OR=1.092, 95% CI:1.002～1.189, P=0.044)和NCR(OR=1.018, 95% CI:1.004～1.033, P=0.015)与DKD风险增加显著相关。结论 DKD的慢性低度炎性反应指标显著升高,hs-CRP、白细胞总数、NCR是DKD的独立危险因素。
Abstract:
Objective To explore the relationship between chronic low-grade inflammation and diabetic kidney disease(DKD).Methods A total of 1 254 patients with type 2 diabetes mellitus(T2DM)were enrolled and divided into two groups:DKD group(487 cases)and T2DM group(767 cases). DKD was diagnosed if the estimated glomerular filtration rate(eGFR)were less than 60 ml/(min·1.73 m2)or if the urine albumin creatinine ratio(UACR)were no less than 30 mg/g. Serum chronic low-grade inflammation indexes including high sensitive C-reactive protein(hs-CRP), total white blood cell count and neutrophil percentage(NCR)were measured with an automatic analyzer. Sex, duration, systolic blood pressure, diastolic blood pressure and other indicators were recorded as well. Multiple Logistic regression analysis was conducted to analyze the relationship between chronic low-grade inflammation indexes and DKD.Results The hs-CRP, total white blood cell count and NCR were significantly higher in DKD group than those in T2DM group(t=-3.60, -3.43, 3.10, all P<0.01). Multiple Logistic regression analysis showed that hs-CRP(OR=1.116, 95% CI:1.042-1.195, P=0.002), total white blood cell count(OR=1.092, 95% CI:1.002-1.189, P=0.044)and NCR(OR=1.018, 95% CI:1.004-1.033, P=0.015)were related to the increased risk of DKD.Conclusions Chronic low-grade inflammation indexes are increased in DKD. Moreover, hs-CRP, total white blood cell count and NCR are independent risk factors of DKD.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81370954,81670785); 国家临床重点专科建设项目; 重庆市基础科学与前沿技术研究专项(cstc2015jcyjBX0096); 重庆市社会事业与民生保障科技创新专项子课题(cstc2016shms-ztzx1003)
通信作者:李启富,Email: liqifu@yeah.net
更新日期/Last Update: 2017-11-30