[1]薛静静,王彦.替米沙坦保护胰岛β细胞功能的研究进展[J].国际内分泌代谢杂志,2017,37(01):42-44.[doi:10.3760/cma.j.issn.1673-4157.2017.01.12]
　Xue Jingjing,Wang Yan..Research progress in protecting islet β cell function of telmisartan[J].International Journal of Endocrinology and Metabolism,2017,37(01):42-44.[doi:10.3760/cma.j.issn.1673-4157.2017.01.12]
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替米沙坦保护胰岛β细胞功能的研究进展()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年01期
页码:
42-44
栏目:
综述
出版日期:
2017-01-20

文章信息/Info

Title:
Research progress in protecting islet β cell function of telmisartan
作者:
薛静静; 王彦
030000 太原,山西医科大学第一医院内分泌科
Author(s):
Xue Jingjing;  Wang Yan.
Department of Endocrinology, The First Hospital, Shanxi Medical University, Taiyuan 030000, China
关键词:
替米沙坦;  胰岛β细胞;  血管紧张素Ⅱ受体拮抗剂;  过氧化物酶体增殖物活化受体γ
Keywords:
Telmisartan;  Islet β cell;  Angiotensin Ⅱ receptor blocker;  Peroxisome proliferator-activated receptor γ
DOI:
10.3760/cma.j.issn.1673-4157.2017.01.12
摘要:
替米沙坦作为血管紧张素Ⅱ受体拮抗剂(ARBs),兼具有部分过氧化物酶体增殖物活化受体γ(PPARγ)激动剂的作用。研究提示,除降压作用外,其还有一定的改善胰岛素抵抗的作用。近年发现,替米沙坦也能够保护胰岛β细胞功能。其机制主要与阻断肾素-血管紧张素系统(RAS)和激活PPARγ有关。
Abstract:
Telmisartan, as an type 1 angiotensin Ⅱ receptor blocker, has the ability to act as apartial agonist of peroxisome proliferator-activated receptor γ(PPARγ). The study suggests that there is a certain improvement in insulin resistance in addition to antihypertensive effect. Recently it is found that telmisartan can protect islet β cell function. The mechanism is mainly related to blocking the renin angiotensin system(RAS)and the activation of PPARγ.

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备注/Memo

备注/Memo:
通信作者:王彦,Email: wyroad@126.com
更新日期/Last Update: 2017-01-20