[1]朱海娇,王幸,陈树春,等.SERCA2b与胰岛β细胞功能[J].国际内分泌代谢杂志,2017,37(06):411-414.
　Zhu Haijiao,Wang Xing,Chen Shuchun,et al.SERCA2b and the function of islet β cells[J].International Journal of Endocrinology and Metabolism,2017,37(06):411-414.
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SERCA2b与胰岛β细胞功能()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
37
期数:
2017年06期
页码:
411-414
栏目:
综述
出版日期:
2017-11-20

文章信息/Info

Title:
SERCA2b and the function of islet β cells
作者:
朱海娇; 王幸; 陈树春; 刘阳; 谢幸
050051 石家庄,河北医科大学内科学教研室,河北省人民医院内分泌科
Author(s):
Zhu Haijiao;  Wang Xing;  Chen Shuchun;  Liu Yang;  Xie Xing.
Department of Internal Medicine, Hebei Medical University; Department of Endocrinology, Hebei General Hospital, Shijiazhuang 050051, China
关键词:
肌浆(内质)网Ca2+ATP酶;  胰岛β细胞;  内质网应激;  糖尿病
Keywords:
Sarco/endoplasmic reticulum Ca2+-ATPase;  Islet β cell;  Endoplasmic reticulum stress;  Diabetes mellitus
文献标志码:
A
摘要:
肌浆(内质)网Ca2+ATP酶(SERCAs)是分布于肌浆网或内质网表面重要的Ca2+调节蛋白,作为其保守亚型,SERCA2b凭借其独特的结构优势可以保护胰岛β细胞功能,从而在胰岛素正常分泌方面起至关重要的作用。大量研究表明,糖尿病患者体内胰岛β细胞数目明显减少,高糖、炎性因子等因素,通过激活内质网应激降低SERCA2b水平,介导胰岛β细胞损伤和凋亡,此过程可能涉及一氧化氮、AMP活化蛋白激酶(AMPK)、肌醇需求激酶1α(IRE1α)-c-jun氨基末端激酶(JNK)介导的多种信号通路,而提高SERCA2b活性能够逆转损伤,保护胰岛β细胞,改善糖代谢。因此,SERCA2b激动剂也为治疗糖尿病提供了新的方向。
Abstract:
Sarco/endoplasmic reticulum Ca2+-ATPase(SERCAs)is a series of important Ca2+ regulatory proteins distributed on the surface of the sarcoplasmic reticulum or endoplasmic reticulum. As conservative subtypes, SERCA2b plays a vital role in the function of islet β cell as well as its normally insulin secretion relying on its unique structure. A large number of studies have shown that the number of islet β cells is seriously reduced in patients with diabetes. Factors such as high glucose, inflammatory cytokines mediated β cell injury and apoptosis by decreasing SERCA2b level and activating endoplasmic reticulum stress. Nitric oxide(NO), AMP-activated protein kinase(AMPK), inositol requiring enzyme-1α/c-jun N-terminal kinase(IRE1α/JNK)pathway may be involved in this process. However, this process can be reversed by improving the activity of SERCA2b and islet β cells are protected at the same time. Therefore, SERCA2b agonist provides a new therapeutic target for treating diabetes.

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备注/Memo

备注/Memo:
通信作者:陈树春,Email:guang6701@sina.com
更新日期/Last Update: 2017-11-30