[1]陈煜,曹萌,刘超.自噬在2型糖尿病中的作用[J].国际内分泌代谢杂志,2016,36(05):346-348.[doi:10.3760/cma.j.issn.1673-4157.2016.05.16]
 Chen Yu,Cao Meng,Liu Chao.Role of autophagy in type 2 diabetes mellitus[J].International Journal of Endocrinology and Metabolism,2016,36(05):346-348.[doi:10.3760/cma.j.issn.1673-4157.2016.05.16]
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自噬在2型糖尿病中的作用()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
36
期数:
2016年05期
页码:
346-348
栏目:
综述
出版日期:
2016-09-20

文章信息/Info

Title:
Role of autophagy in type 2 diabetes mellitus
作者:
陈煜曹萌刘超
210028 南京,中国中医科学院江苏分院,南京中医药大学附属中西医结合医院内分泌代谢病院区
Author(s):
Chen Yu Cao Meng Liu Chao
Endocrine and Diabetes Center, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing University of Traditional Chinese Medicine, Jiangsu Branch of China Academy of Chinese Medicine Science, Nanjing 210028, China
关键词:
自噬 胰岛β细胞 胰岛素抵抗 2型糖尿病
Keywords:
Autophagy Islet β cell Insulin resistance Type 2 diabetes mellitus
DOI:
10.3760/cma.j.issn.1673-4157.2016.05.16
摘要:
胰岛β细胞功能缺陷和胰岛素抵抗是2型糖尿病发病的主要机制。自噬作为一种真核生物细胞中溶 酶体降解胞质成分的重要代谢过程,广泛参与包括2型糖尿病在内的多种疾病的病理过程。在2型糖尿病中,自噬 水平的提高有利于维持胰岛β细胞正常的结构、功能以及改善胰岛素抵抗。进一步探究自噬与2型糖尿病发病 机制之间的关系可能会给糖尿病的治疗带来新的靶点。
Abstract:
Islet β cell failure and insulin resistance are key steps in the onset of type 2 diabetes mellitus. Autophagy is a catabolic process of the lysosomal degradation of cellular components which is crucial in the pathogenesis of numerous diseases including type 2 diabetes. The elevated level of autophagy in type 2 diabetes was helpful to stabilize the structure and function of β cell and ameliorate the state of insulin resistance. To further explore the mechanism between autophagy and type 2 diabetes will bring new hopes to the treatment of diabetes.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(81471010) 通信作者:刘超,Email:liuchao@nfmcn.com
更新日期/Last Update: 2016-11-20