[1]钱瑶 曾姣娥 薛君力.白细胞介素-22与2型糖尿病及其并发症[J].国际内分泌代谢杂志,2019,39(05):337-340.[doi:10.3760/cma.j.issn.1673-4157.2019.05.012]
 Qian Yao,Zeng Jiao'e,Xue Junli.Interleukin-22, type 2 diabetes mellitus and its complications[J].International Journal of Endocrinology and Metabolism,2019,39(05):337-340.[doi:10.3760/cma.j.issn.1673-4157.2019.05.012]
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白细胞介素-22与2型糖尿病及其并发症()
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《国际内分泌代谢杂志》[ISSN:1673-4157/CN:12-1383/R]

卷:
39
期数:
2019年05期
页码:
337-340
栏目:
综述
出版日期:
2019-09-20

文章信息/Info

Title:
Interleukin-22, type 2 diabetes mellitus and its complications
作者:
钱瑶1 曾姣娥2 薛君力2
1长江大学医学院临床医学系,荆州 434020; 2荆州市中心医院内分泌科 4340201
Author(s):
Qian Yao1 Zeng Jiao'e2 Xue Junli2
1Medical College, Yangtze University, Jingzhou 434020, China; 2Department of Endocrinology, Jingzhou Central Hospital, Jingzhou 434020, China
关键词:
白细胞介素-22 2型糖尿病 胰岛β细胞 氧化应激
Keywords:
Interleukin-22 Type 2 diabetes mellitus Islet β cells Oxidative stress
DOI:
10.3760/cma.j.issn.1673-4157.2019.05.012
摘要:
白细胞介素(IL)-22是IL-10家族的成员之一。目前,对于IL-22在2型糖尿病(T2DM)患者外周血清中的表达水平仍然存在着争议。IL-22可以通过信号转导与转录激活因子(STAT)3途径调节Reg基因的表达,诱导β细胞再生,也可以通过促进高血糖状态下角质形成细胞的增殖和损伤修复,改善T2DM慢性并发症。进一步了解IL-22在T2DM及其并发症中的作用,可为寻找T2DM及其并发症新的诊断及治疗方法提供帮助。
Abstract:
Interleukin(IL)-22 is a member of the IL-10 family. Currently, the expression level of IL-22 in peripheral blood serum of patients with type 2 diabetes(T2DM)is still controversial. IL-22 can regulate the expression of Reg gene through the signal transduction and activators of transcription(STAT)3 pathway to induce β cell regeneration, and it can also improve the chronic complications of T2DM by promoting the proliferation and damage repairment of keratinocytes in the condition of hyperglycemia. Further understanding of the role of IL-22 in T2DM and its complications can help to find new diagnostic and therapeutic methods for T2DM and its complications.

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备注/Memo

备注/Memo:
通信作者:曾姣娥,Email:nfmzeng@163.com
Corresponding author: Zeng Jiao'e, Email:nfmzeng@163.com
基金项目:湖北省自然科学基金(2017CPB736)
Fund program:Natural Science Foundation of Hubei Province of China(2017CPB736)
更新日期/Last Update: 2019-09-20